The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus
Open accessAbstract
Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight (HHV8) that activates lytic cycle gene expression from the latent viral genome. The gene is a homologue of Rta, a transcriptional activator encoded by Epstein–Barr virus (EBV). KSHV/Rta activated KSHV early lytic genes, including virus-encoded interleukin 6 and polyadenylated nuclear RNA, and a late gene, small viral capsid antigen. In cells dually infected with Epstein–Barr virus and KSHV, each Rta activated only autologous lytic cycle genes. Expression of viral cytokines under control of the KSHV/Rta gene is likely to contribute to the pathogenesis of KSHV-associated diseases.
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Cites
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Cited by
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Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients
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Metadata
- Authors
- Sun, R., Lin, S.-F., Gradoville, L., Yuan, Y., Zhu, F., & Miller, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09
- Volume
- 95
- Issue
- 18
- Pages
- 10866-10871
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2104107907
- Cited by
- 593
- References
- 30
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, R., Lin, S.-F., Gradoville, L., Yuan, Y., Zhu, F., & Miller, G. (1998). A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.18.10866
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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