The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients
Abstract
Natural interferon-α producing cells (IPCs) are a newly characterized blood cell type, which is the major source of type I interferons in antiviral innate immune responses. The relationship between the number of circulating IPCs, HIV disease progression, and the occurrence of HIV-related complications was investigated. The study of 25 healthy donors and 54 HIV-infected subjects demonstrated a direct correlation between blood IPC number, interferon-α production, and clinical state of HIV-infected subjects. Asymptomatic long-term survivors had increased IPC number and function relative to uninfected controls and infected individuals with progressive disease. IPC numbers were markedly reduced in AIDS patients developing opportunistic infections and cancer. A negative correlation was found between the IPC number in the blood and the HIV viral load, suggesting that IPCs are important in controlling HIV replication. This study provides the first evidence that IPCs are being affected during the course of HIV infection and suggests that these cells can play a vital role in the protection against opportunistic pathogens and cancer.
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Cites
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Cited by
IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors
Liu, Y.-J. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115633 · Cited by 1,625
Self-citationC-type lectin receptors on dendritic cells and langerhans cells
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The IFITM Proteins Inhibit HIV-1 Infection
Lu, J., Pan, Q., Rong, L., Liu, S.-L., & Liang, C. (2011) · Journal of Virology · doi:10.1128/jvi.01531-10 · Cited by 417
Swiecki, M., & Colonna, M. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00881.x · Cited by 397
Metadata
- Authors
- Soumelis, V., Scott, I., Gheyas, F., Bouhour, D., Cozon, G., Cotte, L., Huang, L., Levy, J. A., & Liu, Y.-J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2001-08-15
- Volume
- 98
- Issue
- 4
- Pages
- 906-912
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2170339952
- Cited by
- 398
- References
- 35
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Soumelis, V., Scott, I., Gheyas, F., Bouhour, D., Cozon, G., Cotte, L., Huang, L., Levy, J. A., & Liu, Y.-J. (2001). Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood. https://doi.org/10.1182/blood.v98.4.906
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