The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal
Open accessAbstract
Oxidation of endogenous macromolecules can generate electrophiles capable of forming mutagenic adducts in DNA. The lipid peroxidation product malondialdehyde, for example, reacts with DNA to form M 1 G, the mutagenic pyrimidopurinone adduct of deoxyguanosine. In addition to free radical attack of lipids, DNA is also continuously subjected to oxidative damage. Among the products of oxidative DNA damage are base propenals. We hypothesized that these structural analogs of malondialdehyde would react with DNA to form M 1 G. Consistent with this hypothesis, we detected a dose-dependent increase in M 1 G in DNA treated with calicheamicin and bleomycin, oxidizing agents known to produce base propenal. The hypothesis was proven when we determined that 9-(3-oxoprop-1-enyl)adenine gives rise to the M 1 G adduct with greater efficiency than malondialdehyde itself. The reactivity of base propenals to form M 1 G and their presence in the target DNA suggest that base propenals derived from oxidative DNA damage may contribute to the mutagenic burden of a cell.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Reactions of oxyl radicals with DNA
Breen, A. P., & Murphy, J. A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00209-3 · Cited by 1,038
Cited by
Antioxidant enzymes and human diseases
MatÉs, J. M., Pérez-Gómez, C., & De Castro, I. N. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00075-2 · Cited by 2,099
Marnett, L. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.361 · Cited by 1,883
Self-citationLipid peroxidation—DNA damage by malondialdehyde
Marnett, L. J. (1999) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00010-x · Cited by 1,304
Self-citationRole of reactive oxygen species in apoptosis: implications for cancer therapy
Matés, J. M., & Sánchez-Jiménez, F. M. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00088-6 · Cited by 771
Oxy radicals, lipid peroxidation and DNA damage
Marnett, L. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00448-1 · Cited by 560
Self-citation
Metadata
- Authors
- Dedon, P. C., Plastaras, J. P., Rouzer, C. A., & Marnett, L. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09-15
- Volume
- 95
- Issue
- 19
- Pages
- 11113-11116
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2075908319
- Cited by
- 176
- References
- 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal. https://app.cochat.ai/papers/10.1073/pnas.95.19.11113
- The paper
- Dedon, P. C., Plastaras, J. P., Rouzer, C. A., & Marnett, L. J. (1998). Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.19.11113
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
