The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D
Open accessAbstract
Surfactant protein D (SP-D) is one of two collectins found in the pulmonary alveolus. On the basis of homology with other collectins, potential functions for SP-D include roles in innate immunity and surfactant metabolism. The SP-D gene was disrupted in embryonic stem cells by homologous recombination to generate mice deficient in SP-D. Mice heterozygous for the mutant SP-D allele had SP-D concentrations that were approximately 50% wild type but no other obvious phenotypic abnormality. Mice totally deficient in SP-D were healthy to 7 months but had a progressive accumulation of surfactant lipids, SP-A, and SP-B in the alveolar space. By 8 weeks the alveolar phospholipid pool was 8-fold higher than wild-type littermates. There was also a 10-fold accumulation of alveolar macrophages in the null mice, and many macrophages were both multinucleated and foamy in appearance. Type II cells in the null mice were hyperplastic and contained giant lamellar bodies. These alterations in surfactant homeostasis were not associated with detectable changes in surfactant surface activity, postnatal respiratory function, or survival. The findings in the SP-D-deficient mice suggest a role for SP-D in surfactant homeostasis.
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Cites
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789
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Cited by
Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense
Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762
Surfactant proteins SP-A and SP-D: structure, function and receptors
Kishore, U., Greenhough, T. J., Waters, P., Shrive, A. K., Ghai, R., Kamran, M. F., Bernal, A. L., Reid, K. B. M., Madan, T., & Chakraborty, T. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.08.004 · Cited by 523
Mao, J. R., Taylor, G., Dean, W. B., Wagner, D. R., Afzal, V., Lotz, J. C., Rubin, E. M., & Bristow, J. (2002) · Nature Genetics · doi:10.1038/ng850 · Cited by 261
Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
Røe, O. D., & Stella, G. M. (2015) · European Respiratory Review · doi:10.1183/09059180.00007014 · Cited by 185
Identification and Characterization of a Novel Human Collectin CL-K1
Keshi, H., Sakamoto, T., Kawai, T., Ohtani, K., Katoh, T., Jang, S., Motomura, W., Yoshizaki, T., Fukuda, M., Koyama, S., et al. (2006) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2006.tb03868.x · Cited by 150
Metadata
- Authors
- Botas, C., Poulain, F., Akiyama, J., Brown, C., Allen, L., Goerke, J., Clements, J., Carlson, E., Gillespie, A. M., Epstein, C., & Hawgood, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09-29
- Volume
- 95
- Issue
- 20
- Pages
- 11869-11874
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2105381893
- Cited by
- 391
- References
- 1
- FWCI
- 24.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Botas, C., Poulain, F., Akiyama, J., Brown, C., Allen, L., Goerke, J., Clements, J., Carlson, E., Gillespie, A. M., Epstein, C., & Hawgood, S. (1998). Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.20.11869
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