The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Expression of the Epstein–Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice
Open accessAbstract
The latent membrane protein 1 (LMP1) of the Epstein–Barr virus has transforming properties in rodent fibroblasts and is expressed in most of the cancers associated with Epstein–Barr virus (EBV) infection including posttransplant lymphomas, Hodgkin’s disease, nasopharyngeal carcinoma, and AIDS-related lymphomas. In this study, three lineages of LMP1 transgenic mice were established with LMP1 expressed under the control of the Ig heavy chain promoter and enhancer. Lymphoma developed in all three lineages, and the incidence of lymphoma increased significantly with age with lymphomas developing in 42% of transgenic mice over 18 months. The expression of LMP1 was detected at high levels in the lymphoma tissues but only at trace levels in normal lymphoid tissues. Gene rearrangement of the Ig heavy chain indicated monoclonality or oligoclonality in all lymphomas, some of the lymphoid hyperplastic spleens, and some histologically normal spleens. These data reveal that LMP1, without the expression of other EBV genes, is oncogenic in vivo and indicate that LMP1 is a major contributing factor to the development of EBV-associated lymphomas.
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Cites
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Hsu, H., Shu, H.-B., Pan, M.-G., & Goeddel, D. V. (1996) · Cell · doi:10.1016/s0092-8674(00)80984-8 · Cited by 1,998
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,779
An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
Wang, D., Liebowitz, D., & Kieff, E. (1985) · Cell · doi:10.1016/0092-8674(85)90256-9 · Cited by 1,225
Henderson, S., Rowe, M., Gregory, C., Croom-Carter, D., Wang, F., Longnecker, R., Kieff, E., & Rickinson, A. (1991) · Cell · doi:10.1016/0092-8674(91)90007-l · Cited by 1,168
TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40
Rothe, M., Sarma, V., Dixit, V. M., & Goeddel, D. V. (1995) · Science · doi:10.1126/science.7544915 · Cited by 1,051
Mosialos, G., Birkenbacht, M., Yalamanchill, R., Van Arsdale, T., Ware, C., & Kleff, E. (1995) · Cell · doi:10.1016/0092-8674(95)90489-1 · Cited by 980
The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation
Raab-Traub, N., & Flynn, K. (1986) · Cell · doi:10.1016/0092-8674(86)90803-2 · Cited by 912
Self-citationNovel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
Strasser, A., Harris, A. W., Bath, M. L., & Cory, S. (1990) · Nature · doi:10.1038/348331a0 · Cited by 905
McDonnell, T. J., & Korsmeyer, S. J. (1991) · Nature · doi:10.1038/349254a0 · Cited by 858
Cited by
Cohen, J. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008173430707 · Cited by 1,636
The biology of Hodgkin's lymphoma
Küppers, R. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2542 · Cited by 688
Latency and lytic replication in Epstein–Barr virus-associated oncogenesis
Münz, C. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0249-7 · Cited by 469
Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses
Uchida, J., Yasui, T., Takaoka-Shichijo, Y., Muraoka, M., Kulwichit, W., Raab-Traub, N., & Kikutani, H. (1999) · Science · doi:10.1126/science.286.5438.300 · Cited by 437
Self-citationGatto, G., Rossi, A., Rossi, D., Kroening, S., Bonatti, S., & Mallardo, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn666 · Cited by 254
Metadata
- Authors
- Kulwichit, W., Edwards, R. H., Davenport, E. M., Baskar, J. F., Godfrey, V., & Raab-Traub, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09-29
- Volume
- 95
- Issue
- 20
- Pages
- 11963-11968
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2138241311
- Cited by
- 414
- References
- 35
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Kulwichit, W., Edwards, R. H., Davenport, E. M., Baskar, J. F., Godfrey, V., & Raab-Traub, N. (1998). Expression of the Epstein–Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.20.11963
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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