The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses
Abstract
The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.
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The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
Hsu, H., Xiong, J., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90070-5 · Cited by 2,012
A novel form of Epstein-Barr virus latency in normal B cells in vivo
Miyashita, E. M., Yang, B., Lam, K. M. C., Crawford, D. H., & Thorley-Lawson, D. A. (1995) · Cell · doi:10.1016/0092-8674(95)90513-8 · Cited by 1,593
An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
Wang, D., Liebowitz, D., & Kieff, E. (1985) · Cell · doi:10.1016/0092-8674(85)90256-9 · Cited by 1,225
Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., & Kikutani, H. (1994) · Immunity · doi:10.1016/1074-7613(94)90095-7 · Cited by 1,108
Self-citationRothe, M., Wong, S. C., Henzel, W. J., & Goeddel, D. V. (1994) · Cell · doi:10.1016/0092-8674(94)90532-0 · Cited by 1,054
Mosialos, G., Birkenbacht, M., Yalamanchill, R., Van Arsdale, T., Ware, C., & Kleff, E. (1995) · Cell · doi:10.1016/0092-8674(95)90489-1 · Cited by 980
Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6
Dent, A. L., Shaffer, A. L., Yu, X., Allman, D., & Staudt, L. M. (1997) · Science · doi:10.1126/science.276.5312.589 · Cited by 945
EBV Persistence in Memory B Cells In Vivo
Babcock, G. J., Decker, L. L., Volk, M., & Thorley-Lawson, D. A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80622-6 · Cited by 825
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
Ye, B. H., Cattoretti, G., Shen, Q., Zhang, J., Hawe, N., Waard, R. D., Leung, C., Nouri-Shirazi, M., Orazi, A., Chaganti, R. S. K., et al. (1997) · Nature Genetics · doi:10.1038/ng0697-161 · Cited by 820
Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.
Kaye, K. M., Izumi, K. M., & Kieff, E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9150 · Cited by 762
Cited by
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Cohen, J. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008173430707 · Cited by 1,636
Epstein-Barr virus: exploiting the immune system
Thorley-Lawson, D. A. (2001) · Nature Reviews Immunology · doi:10.1038/35095584 · Cited by 939
To kill or be killed: viral evasion of apoptosis
Benedict, C. A., Norris, P. S., & Ware, C. F. (2002) · Nature Immunology · doi:10.1038/ni1102-1013 · Cited by 431
Epstein-Barr virus—recent advances
Macsween, K. F., & Crawford, D. H. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00543-7 · Cited by 344
Metadata
- Authors
- Uchida, J., Yasui, T., Takaoka-Shichijo, Y., Muraoka, M., Kulwichit, W., Raab-Traub, N., & Kikutani, H.
- Venue
- Science
- Published
- 1999-10-08
- Volume
- 286
- Issue
- 5438
- Pages
- 300-303
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042610497
- Cited by
- 437
- References
- 44
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Uchida, J., Yasui, T., Takaoka-Shichijo, Y., Muraoka, M., Kulwichit, W., Raab-Traub, N., & Kikutani, H. (1999). Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses. Science. https://doi.org/10.1126/science.286.5438.300
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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