The DOI matches its Crossref record.
Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing
Open accessAbstract
The glial cells missing ( gcm ) gene in Drosophila encodes a transcription factor that determines the choice between glial and neuronal fates. We report here the isolation of two mammalian gcm homologs, Gcm1 and Gcm2 , and the characterization of their expression patterns during embryonic development. Although Gcm2 is expressed in neural tissues at a low level, the major sites of expression for both of the mammalian genes are nonneural, suggesting that the functions of the mammalian homologs have diverged and diversified. However, when expressed ectopically, Gcm1 can substitute functionally for Drosophila gcm by transforming presumptive neurons into glia. Thus, certain biochemical properties, although not the specificity of the tissue in which the gene is expressed, have been conserved through the evolution of the Gcm gene family.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Lu, Q. R., Yuk, D.-I., Alberta, J. A., Zhu, Z., Pawlitzky, I., Chan, J., McMahon, A. P., Stiles, C. D., & Rowitch, D. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80897-1 · Cited by 852
Astrocytes and disease: a neurodevelopmental perspective
Molofsky, A. V., Krenick, R., Ullian, E., Tsai, H.-H., Deneen, B., Richardson, W. D., Barres, B. A., & Rowitch, D. H. (2012) · Genes & Development · doi:10.1101/gad.188326.112 · Cited by 682
Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors
Lebestky, T., Chang, T., Hartenstein, V., & Banerjee, U. (2000) · Science · doi:10.1126/science.288.5463.146 · Cited by 494
Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina
Hojo, M., Ohtsuka, T., Hashimoto, N., Gradwohl, G., Guillemot, F., & Kageyama, R. (2000) · Development · doi:10.1242/dev.127.12.2515 · Cited by 278
Metadata
- Authors
- Kim, J., Jones, B. W., Zock, C., Chen, Z., Wang, H., Goodman, C. S., & Anderson, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-10-13
- Volume
- 95
- Issue
- 21
- Pages
- 12364-12369
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2046951891
- Cited by
- 200
- References
- 0
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. https://app.cochat.ai/papers/10.1073/pnas.95.21.12364
- The paper
- Kim, J., Jones, B. W., Zock, C., Chen, Z., Wang, H., Goodman, C. S., & Anderson, D. J. (1998). Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.21.12364
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
