The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors
Abstract
Two major classes of cells observed within the Drosophila hematopoietic repertoire are plasmatocytes/macrophages and crystal cells. The transcription factor Lz (Lozenge), which resembles human AML1 (acute myeloid leukemia– 1) protein, is necessary for the development of crystal cells during embryonic and larval hematopoiesis. Another transcription factor, Gcm (glial cells missing), has previously been shown to be required for plasmatocyte development. Misexpression of Gcm causes crystal cells to be transformed into plasmatocytes. The Drosophila GATA protein Srp (Serpent) is required for both Lz and Gcm expression and is necessary for the development of both classes of hemocytes, whereas Lz and Gcm are required in a lineage-specific manner. Given the similarities of Srp and Lz to mammalian GATA and AML1 proteins, observations in Drosophila are likely to have broad implications for understanding mammalian hematopoiesis and leukemias.
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Cited by
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
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Analysis of Ras-Induced Overproliferation in Drosophila Hemocytes
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Metadata
- Authors
- Lebestky, T., Chang, T., Hartenstein, V., & Banerjee, U.
- Venue
- Science
- Published
- 2000-04-07
- Volume
- 288
- Issue
- 5463
- Pages
- 146-149
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040236732
- Cited by
- 494
- References
- 27
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lebestky, T., Chang, T., Hartenstein, V., & Banerjee, U. (2000). Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors. Science. https://doi.org/10.1126/science.288.5463.146
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