The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry
Open accessAbstract
The discovery of cyanobacterial phytochrome histidine kinases, together with the evidence that phytochromes from higher plants display protein kinase activity, bind ATP analogs, and possess C-terminal domains similar to bacterial histidine kinases, has fueled the controversial hypothesis that the eukaryotic phytochrome family of photoreceptors are light-regulated enzymes. Here we demonstrate that purified recombinant phytochromes from a higher plant and a green alga exhibit serine/threonine kinase activity similar to that of phytochrome isolated from dark grown seedlings. Phosphorylation of recombinant oat phytochrome is a light- and chromophore-regulated intramolecular process. Based on comparative protein sequence alignments and biochemical cross-talk experiments with the response regulator substrate of the cyanobacterial phytochrome Cph1, we propose that eukaryotic phytochromes are histidine kinase paralogs with serine/threonine specificity whose enzymatic activity diverged from that of a prokaryotic ancestor after duplication of the transmitter module.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Active and Inactive Protein Kinases: Structural Basis for Regulation
Johnson, L. N., Noble, M. E. M., & Owen, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81092-2 · Cited by 1,403
Studies on histones. 7. Preparative methods for histone fractions from calf thymus
Johns, E. (1964) · Biochemical Journal · doi:10.1042/bj0920055 · Cited by 1,038
Phytochromes: Photosensory Perception and Signal Transduction
Quail, P. H., Boylan, M. T., Parks, B. M., Short, T. W., Xu, Y., & Wagner, D. (1995) · Science · doi:10.1126/science.7732376 · Cited by 751
A Cyanobacterial Phytochrome Two-Component Light Sensory System
Yeh, K.-C., Wu, S.-H., Murphy, J. T., & Lagarias, J. C. (1997) · Science · doi:10.1126/science.277.5331.1505 · Cited by 537
Self-citationPAS is a dimerization domain common to Drosophila Period and several transcription factors
Huang, Z. J., Edery, I., & Rosbash, M. (1993) · Nature · doi:10.1038/364259a0 · Cited by 512
SAGA: sequence alignment by genetic algorithm
Notredame, C. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.8.1515 · Cited by 510
Physiological and Ecological Function within the Phytochrome Family
Smith, H. (1995) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.46.1.289 · Cited by 489
van't Hoff, M. J. H. (1884) · Recueil des Travaux Chimiques des Pays-Bas · doi:10.1002/recl.18840031003 · Cited by 488
Cited by
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
Initiative, T. A. G. (2000) · Nature · doi:10.1038/35048692 · Cited by 9,301
PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
Taylor, B. L., & Zhulin, I. B. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.479-506.1999 · Cited by 1,632
Phytochromes and light signal perception by plants—an emerging synthesis
Smith, H. (2000) · Nature · doi:10.1038/35036500 · Cited by 1,380
Light-Regulated Plant Growth and Development
Kami, C., Lorrain, S., Hornitschek, P., & Fankhauser, C. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)91002-8 · Cited by 927
Phytochrome Signaling Mechanisms
Li, J., Li, G., Wang, H., & Wang Deng, X. (2011) · The Arabidopsis Book · doi:10.1199/tab.0148 · Cited by 561
Metadata
- Authors
- Yeh, K.-C., & Lagarias, J. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-11-10
- Volume
- 95
- Issue
- 23
- Pages
- 13976-13981
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967551062
- Cited by
- 411
- References
- 34
- FWCI
- 49.04
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry. https://app.cochat.ai/papers/10.1073/pnas.95.23.13976
- The paper
- Yeh, K.-C., & Lagarias, J. C. (1998). Eukaryotic phytochromes: Light-regulated serine/threonine protein kinases with histidine kinase ancestry. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.23.13976
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
