The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Vascular endothelial growth factor C induces angiogenesis in vivo
Open accessAbstract
Vascular endothelial growth factor C (VEGF-C) recently has been described to be a relatively specific growth factor for the lymphatic vascular system. Here we report that ectopic application of recombinant VEGF-C also has potent angiogenic effects in vivo . VEGF-C is sufficiently potent to stimulate neovascularization from limbal vessels in the mouse cornea. Similar to VEGF, the angiogenic response of corneas induced by VEGF-C is intensive, with a high density of new capillaries. However, the outgrowth of microvessels stimulated by VEGF-C was significantly longer than that induced by VEGF. In the developing embryo, VEGF-C was able to induce branch sprouts from the established blood vessels. VEGF-C also induced an elongated, spindle-like cell shape change and actin reorganization in both VEGF receptor (VEGFR)-2 and VEGFR-3-overexpressing endothelial cells, but not in VEGFR-1-expressing cells. Further, both VEGFR-2 and VEGFR-3 could mediate proliferative and chemotactic responses in endothelial cells on VEGF-C stimulation. Thus, VEGF-C may regulate physiological angiogenesis and participate in the development and progression of angiogenic diseases in addition to lymphangiogenesis.
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Cites
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
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The Biology of Vascular Endothelial Growth Factor
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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,117
Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid
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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
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THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES
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Cited by
PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
Lymphangiogenesis in development and human disease
Alitalo, K., Tammela, T., & Petrova, T. V. (2005) · Nature · doi:10.1038/nature04480 · Cited by 1,285
Self-citationThe splice variants of vascular endothelial growth factor (VEGF) and their receptors
Robinson, C. J., & Stringer, S. E. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.5.853 · Cited by 944
Vascular endothelial growth factors and angiogenesis in eye disease
Witmer, A. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00043-5 · Cited by 927
Makinen, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4762 · Cited by 845
Metadata
- Authors
- Cao, Y., Linden, P., Farnebo, J., Cao, R., Eriksson, A., Kumar, V., Qi, J.-H., Claesson-Welsh, L., & Alitalo, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-11-24
- Volume
- 95
- Issue
- 24
- Pages
- 14389-14394
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2057697484
- Cited by
- 565
- References
- 45
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Cao, Y., Linden, P., Farnebo, J., Cao, R., Eriksson, A., Kumar, V., Qi, J.-H., Claesson-Welsh, L., & Alitalo, K. (1998). Vascular endothelial growth factor C induces angiogenesis in vivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.24.14389
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
