Mechanisms of angiogenesis
Abstract
After the developing embryo has formed a primary vascular plexus by a process termed vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting angiogenesis, which are progressively pruned and remodelled into a functional adult circulatory system. Recent results, particularly from the study of mice lacking some of the signalling systems involved, have greatly improved our understanding of the molecular basis underlying these events, and may suggest new approaches for treating conditions such as cancer that depend on angiogenesis.
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In vivo, dormancy is typically overcome through angiogenesis, during which newly formed blood vessels introduce shear forces that sustain endothelial sprouts and support the delivery of therapeutic agents.
“In vivo, this dormancy is typically overcome through angiogenesis, during which newly formed blood vessels introduce shear forces that sustain endothelial sprouts and support the delivery of therapeutic agents [49,222].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [222]
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- Authors
- Risau, W.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Risau, Werner
- Venue
- Nature
- Published
- 1997-04
- Volume
- 386
- Issue
- 6626
- Pages
- 671-674
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1679229092
- Cited by
- 5,727
- References
- 2
- Citations by year
- 2026: 56 · 2025: 74 · 2024: 91 · 2023: 120 · 2022: 130 · 2021: 148 · 2020: 143 · 2019: 137 · 2018: 161 · 2017: 154 · 2016: 171 · 2015: 202 · 2014: 208 · 2013: 218 · 2012: 216
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- angiogenesis, vasculogenesis, sprouting angiogenesis, vascular pruning, vascular remodeling, blood vessel development, signaling pathways, anti-angiogenic therapy, tumor angiogenesis
- MeSH terms
- Animals, Blood Vessels, Humans, Neovascularization, Physiologic
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