The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families
Open accessAbstract
Systemic lupus erythematosus (SLE) is an autoimmune multisystem inflammatory disease characterized by the production of pathogenic autoantibodies. Previous genetic studies have suggested associations with HLA Class II alleles, complement gene deficiencies, and Fc receptor polymorphisms; however, it is likely that other genes contribute to SLE susceptibility and pathogenesis. Here, we report the results of a genome-wide microsatellite marker screen in 105 SLE sib-pair families. By using multipoint nonparametric methods, the strongest evidence for linkage was found near the HLA locus (6p11-p21) [ D6S257 , logarithm of odds (lod) = 3.90, P = 0.000011] and at three additional regions: 16q13 ( D16S415 , lod = 3.64, P = 0.000022), 14q21–23 ( D14S276 , lod = 2.81, P = 0.00016), and 20p12 ( D20S186 , lod = 2.62, P = 0.00025). Another nine regions (1p36, 1p13, 1q42, 2p15, 2q21–33, 3cent-q11, 4q28, 11p15, and 15q26) were identified with lod scores ≥1.00. These data support the hypothesis that multiple genes, including one in the HLA region, influence susceptibility to human SLE.
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Cites
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Cited by
Prokunina, L., Castillejo-López, C., Öberg, F., Gunnarsson, I., Berg, L., Magnusson, V., Brookes, A. J., Tentler, D., Kristjansdóttir, H., Gröndal, G., et al. (2002) · Nature Genetics · doi:10.1038/ng1020 · Cited by 769
Graham, R. R., Kyogoku, C., Sigurdsson, S., Vlasova, I. A., Davies, L. R. L., Baechler, E. C., Plenge, R. M., Koeuth, T., Ortmann, W. A., Hom, G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701266104 · Cited by 450
Self-citationThe genetics of complex autoimmune diseases: non-MHC susceptibility genes
Wanstrat, A., & Wakeland, E. (2001) · Nature Immunology · doi:10.1038/ni0901-802 · Cited by 383
Yoh, K., Itoh, K., Enomoto, A., Hirayama, A., Yamaguchi, N., Kobayashi, M., Morito, N., Koyama, A., Yamamoto, M., & Takahashi, S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00939.x · Cited by 344
Higgs, R., Gabhann, J. N., Larbi, N. B., Breen, E. P., Fitzgerald, K. A., & Jefferies, C. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1780 · Cited by 310
Metadata
- Authors
- Gaffney, P. M., Kearns, G. M., Shark, K. B., Ortmann, W. A., Selby, S. A., Malmgren, M. L., Rohlf, K. E., Ockenden, T. C., Messner, R. P., King, R. A., Rich, S. S., & Behrens, T. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-12-08
- Volume
- 95
- Issue
- 25
- Pages
- 14875-14879
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2168651519
- Cited by
- 355
- References
- 27
- FWCI
- 23.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Gaffney, P. M., Kearns, G. M., Shark, K. B., Ortmann, W. A., Selby, S. A., Malmgren, M. L., Rohlf, K. E., Ockenden, T. C., Messner, R. P., King, R. A., Rich, S. S., & Behrens, T. W. (1998). A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.25.14875
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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