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Cited by 304

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

Open access
Holland, Eric C., Varmus, Harold E.·1998·Proceedings of the National Academy of Sciences

Abstract

Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade human gliomas, implying that it is involved in the pathogenesis of these tumors. To assess the biological effect of inappropriate production of bFGF in normal astrocytes, we developed a system for glia-specific gene transfer in transgenic mice. A transgene encoding the receptor for subgroup A avian leukosis virus and controlled by the astrocyte-specific glial fibrillary acidic protein promoter permits efficient glia-specific transfer of genes carried by subgroup A avian leukosis virus vectors. With this system, we have demonstrated that bFGF induces proliferation and migration of glial cells in vivo, without the induction of tumors.

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Crossref · 10.1073/pnas.95.3.1218

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Metadata

Authors
Holland, E. C., & Varmus, H. E.
Venue
Proceedings of the National Academy of Sciences
Published
1998-02-03
Volume
95
Issue
3
Pages
1218-1223
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1978956991
Cited by
304
References
2
FWCI
9.85
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. https://app.cochat.ai/papers/10.1073/pnas.95.3.1218
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Holland, E. C., & Varmus, H. E. (1998). Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.3.1218

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.