Cited by 255Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsGenomics and Chromatin Dynamics

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CREB-binding protein in androgen receptor-mediated signaling

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Aarnisalo, Piia, Palvimo, Jorma J., Jänne, Olli A.·1998·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.95.5.2122PMC PMC19270

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Abstract

CREB-binding protein (CBP) is a transcriptional coregulator that interacts with different DNA binding proteins and components of the general transcription machinery. CBP enhanced androgen receptor (AR)-dependent transcription under transient transfection conditions in CV-1 cells. The ligand binding domain (LBD) and residues 38–296 of the N-terminal region of AR are not required because the activity of a receptor mutant devoid of these domains was augmented by coexpressed CBP. There is physical interaction between AR and CBP in vivo , as judged by coimmunoprecipitation experiments from cell extracts. Consistent with the role of CBP as a coactivator for AR, the 12S E1A adenoviral protein that inactivates CBP function strongly inhibited AR-dependent transactivation. Exogenous CBP was also capable of overcoming the inhibitory effect of AR on AP-1 activity and diminished the mutual transcriptional repression between AR and NF-κB (RelA). Collectively, these data imply that transcriptional interference between AR and AP-1 or NF-κB is mediated, at least in part, through competition for intracellular CBP and that this coactivator serves as an integrator between androgen-mediated and other signaling pathways.

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Authors: Aarnisalo, P., Palvimo, J. J., & Jänne, O. A.
Affiliations: University of Helsinki (FI)
ORCID: Palvimo, Jorma J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1998-03-03
Volume: 95
Issue: 5
Pages: 2122-2127
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.95.5.2122
PMC: PMC19270
OpenAlex: W2023929246
Cited by: 255
References: 56
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 3 · 2013: 9 · 2012: 6
FWCI: 23.10
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: CREB-binding protein, androgen receptor, transcriptional coactivator, AP-1, NF-κB, RelA, transcriptional repression, transcriptional interference, E1A protein, ligand-binding domain, protein-protein interaction, signaling pathway integration
MeSH terms: Animals, Binding Sites, Cell Line, Humans, Kinetics, Nuclear Proteins, Receptors, Androgen, Receptors, Glucocorticoid, Transcription Factors, Transcription, Genetic, Transfection, Protein Engineering, Signal Transduction, Transcriptional Activation, Trans-Activators, Sequence Deletion, Transcription Factor AP-1, COS Cells, CREB-Binding Protein, Rats

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CREB-binding protein in androgen receptor-mediated signaling

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