The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity
Open accessAbstract
The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.
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Cites
Individual Comparisons by Ranking Methods
Wilcoxon, F. (1945) · Biometrics Bulletin · doi:10.2307/3001968 · Cited by 15,354
Agarwal, M. L., Agarwal, A., Taylor, W. R., & Stark, G. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8493 · Cited by 858
Cited by
Xu, X., Weaver, Z., Linke, S. P., Li, C., Gotay, J., Wang, X.-W., Harris, C. C., Ried, T., & Deng, C.-X. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819
Centrosome aberrations: cause or consequence of cancer progression?
Nigg, E. A. (2002) · Nature Reviews Cancer · doi:10.1038/nrc924 · Cited by 732
Meraldi, P. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.483 · Cited by 658
Pleiotropic cell-division defects and apoptosis induced by interference with survivin function
Li, F., Ackermann, E. J., Bennett, C. F., Rothermel, A. L., Plescia, J., Tognin, S., Villa, A., Marchisio, P. C., & Altieri, D. C. (1999) · Nature Cell Biology · doi:10.1038/70242 · Cited by 600
Centrosome Amplification Can Initiate Tumorigenesis in Flies
Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A., & Raff, J. W. (2008) · Cell · doi:10.1016/j.cell.2008.05.039 · Cited by 560
Metadata
- Authors
- Lingle, W. L., Lutz, W. H., Ingle, J. N., Maihle, N. J., & Salisbury, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-03-17
- Volume
- 95
- Issue
- 6
- Pages
- 2950-2955
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068121956
- Cited by
- 515
- References
- 2
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Lingle, W. L., Lutz, W. H., Ingle, J. N., Maihle, N. J., & Salisbury, J. L. (1998). Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.6.2950
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
