p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

Antibodies, a laboratory manual

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318 · see citing works

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321 · see citing works

p53 Mutations in Human Cancers

Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018 · see citing works

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651 · see citing works

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138 · see citing works

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · see citing works

Participation of p53 protein in the cellular response to DNA damage.

Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761 · see citing works

p21 is a universal inhibitor of cyclin kinases

Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691 · see citing works

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463 · see citing works

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Lowe, S. W., Ruley, H. E., Jacks, T., & Housman, D. E. (1993) · Cell · doi:10.1016/0092-8674(93)90719-7 · Cited by 2,911 · see citing works

Universal control mechanism regulating onset of M-phase

Nurse, P. (1990) · Nature · doi:10.1038/344503a0 · Cited by 2,882 · see citing works

p53 is required for radiation-induced apoptosis in mouse thymocytes

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864 · see citing works

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

El‐Deiry, W. S., Harper, J. W., O'Connor, P. M., Velculescu, V. E., Ce, C., Jackman, J., Pietenpol, J. A., Burrell, M., De, H., & Wang, Y. (1994) · PubMed · Cited by 2,021 · see citing works

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

Livingstone, L. R., White, A., Sprouse, J., Livanos, E., Jacks, T., & Tlsty, T. D. (1992) · Cell · doi:10.1016/0092-8674(92)90243-6 · Cited by 1,333 · see citing works

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Di Leonardo, A., Linke, S. P., Clarkin, K., & Wahl, G. M. (1994) · Genes & Development · doi:10.1101/gad.8.21.2540 · Cited by 1,215 · see citing works

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

Yin, Y., Tainsky, M. A., Bischoff, F. Z., Strong, L. C., & Wahl, G. M. (1992) · Cell · doi:10.1016/0092-8674(92)90244-7 · Cited by 1,089 · see citing works

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

Michalovitz, D., Halevy, O., & Oren, M. (1990) · Cell · doi:10.1016/0092-8674(90)90113-s · Cited by 769 · see citing works

Induction of WAF1/CIP1 by a p53-independent pathway.

Michieli, P., Chedid, M., Lin, D. P., Pierce, J. H., Mercer, W. E., & Givol, D. (1994) · PubMed · Cited by 768 · see citing works

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.Preprint

Martinez, J., Georgoff, I., Martinez, J., & Levine, A. J. (1991) · Genes & Development · doi:10.1101/gad.5.2.151 · Cited by 528 · see citing works

Sequence-specific transcriptional activation is essential for growth suppression by p53.

Pietenpol, J. A., Tokino, T., Thiagalingam, S., El‐Deiry, W. S., Kinzler, K. W., & Vogelstein, B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.1998 · Cited by 406 · see citing works

Untitled work

(1993) · PubMed · Cited by 323 · see citing works

Evidence for a second cell cycle block at G2/M by p53.

Stewart, N., Hicks, G. G., PARASKEVAS, F., & Mowat, M. R. A. (1995) · PubMed · Cited by 300 · see citing works

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

Lin, D., Shields, M. T., Ullrich, S. J., Appella, E., & Mercer, W. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9210 · Cited by 267 · see citing works

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

Bischoff, F. Z., Yim, S. O., Pathak, S., Grant, G., Siciliano, M. J., Giovanella, B. C., Strong, L. C., & Tainsky, M. A. (1990) · PubMed · Cited by 252 · see citing works

A reversible arrest point in the late G1 phase of the mammalian cell cycle

Lalande, M. (1990) · Experimental Cell Research · doi:10.1016/0014-4827(90)90313-y · Cited by 202 · see citing works

Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.

O'Connor, P. M., Ferris, D. K., Hoffmann, I., Jackman, J., Draetta, G. F., & Kohn, K. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9480 · Cited by 86 · see citing works

Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53

Vikhanskaya, F., Erba, E., D’Incalci, M., & Broggini, M. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.6.1012 · Cited by 49 · see citing works

Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro.

Little, J. B., Nove, J., Dahlberg, W. K., Troilo, P. J., Nichols, W. W., & Strong, L. C. (1987) · PubMed · Cited by 40 · see citing works

Cell Cycle Regulation of Gene AmplificationPreprint

Leonardo, A. D., Linke, S. P., Yin, Y., & Wahl, G. M. (1993) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1993.058.01.073 · Cited by 26 · see citing works

The p53-mediated G 1 checkpoint is retained in tumorigenic rat embryo fibroblast clones transformed by the human papillomavirus type 16 E7 gene and EJ- ras

Peacock, J. W., Chung, S., Bristow, R. G., Hill, R. P., & Benchimol, S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1446 · Cited by 26 · see citing works

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803 · see citing works

p53: puzzle and paradigm.Preprint

Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,338 · see citing works

The extracellular matrix modulates the hallmarks of cancer

Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,014 · see citing works

Regulation of the G2/M transition by p53

Taylor, W. R., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204252 · Cited by 1,553 · see citing works

Is a p53-Regulated Inhibitor of G2/M Progression

Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251 · see citing works

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

Stott, F. J., Bates, S., James, M. C., McConnell, B. B., Starborg, M., Brookes, S., Palmero, I., Ryan, K. M., Hara, E., Vousden, K. H., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5001 · Cited by 1,165 · see citing works

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

Hung, T., Wang, Y., Lin, M. F., Koegel, A. K., Kotake, Y., Grant, G. D., Horlings, H. M., Shah, N., Umbricht, C. B., Wang, P., et al. (2011) · Nature Genetics · doi:10.1038/ng.848 · Cited by 1,165 · see citing works

The antioxidant function of the p53 tumor suppressor

Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works

Untitled work

(1999) · PubMed · Cited by 1,030 · see citing works

p53 and Human Cancer: The First Ten Thousand Mutations

Hainaut, P. L., & Hollstein, M. C. (1999) · Advances in cancer research · doi:10.1016/s0065-230x(08)60785-x · Cited by 980 · see citing works

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876 · see citing works

Gold Nanoparticles of Diameter 1.4 nm Trigger Necrosis by Oxidative Stress and Mitochondrial Damage

Pan, Y., Leifert, A., Ruau, D., Neuß, S., Bornemann, J., Schmid, G., Brandau, W., Simon, U., & Jahnen‐Dechent, W. (2009) · Small · doi:10.1002/smll.200900466 · Cited by 802 · see citing works

Abnormal Centrosome Amplification in the Absence of p53

Fukasawa, K., Choi, T., Kuriyama, R., Rulong, S., & Woude, G. F. V. (1996) · Science · doi:10.1126/science.271.5256.1744 · Cited by 798 · see citing works

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

Chen, X., Ko, L. J., Jayaraman, L., & Prives, C. (1996) · Genes & Development · doi:10.1101/gad.10.19.2438 · Cited by 735 · see citing works

The p53 Network

Agarwal, M. L., Taylor, W. R., Chernov, M. V., Chernova, O. B., & Stark, G. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.1 · Cited by 725 · see citing works

Effects of p21 Cip1/Waf1 at Both the G 1 /S and the G 2 /M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

Niculescu, A. B., Chen, X., Smeets, M. F. M. A., Hengst, L., Prives, C. L., & Reed, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.629 · Cited by 725 · see citing works

Cyclins and cell cycle checkpoints.

Johnson, D. G., & Walker, C. (1999) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.295 · Cited by 789 · see citing works

Twenty years of p53 research: structural and functional aspects of the p53 protein

May, P., & May, E. (1999) · Oncogene · doi:10.1038/sj.onc.1203285 · Cited by 663 · see citing works

Cell Cycle and Apoptosis

Pucci, B., Kasten, M. M., & Giordano, A. (2000) · Neoplasia · doi:10.1038/sj.neo.7900101 · Cited by 659 · see citing works

Involvement of Brca2 in DNA Repair

Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 631 · see citing works

GADD45 induction of a G ₂ /M cell cycle checkpoint

Wang, X. W., Zhan, Q., Coursen, J. D., Khan, M. A., Kontny, H. U., Yu, L., Hollander, M. C., O’Connor, P. M., Fornace, A. J., & Harris, C. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3706 · Cited by 634 · see citing works

The Cell Cycle: A Review

Schafer, K. A. (1998) · Veterinary Pathology · doi:10.1177/030098589803500601 · Cited by 609 · see citing works

Control of cell cycle progression by c-Jun is p53 dependentPreprint

Schreiber, M., Kolbus, A., Piu, F., Szabowski, A., Möhle-Steinlein, U., Tian, J., Karin, M., Angel, P., & Wagner, E. F. (1999) · Genes & Development · doi:10.1101/gad.13.5.607 · Cited by 576 · see citing works

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

Fiscella, M., Zhang, H., Fan, S., Sakaguchi, K., Shen, S., Mercer, W. E., Woude, G. F. V., O'Connor, P. M., & Appella, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6048 · Cited by 527 · see citing works

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

Lingle, W. L., Lutz, W. H., Ingle, J. N., Maihle, N. J., & Salisbury, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2950 · Cited by 515 · see citing works

p21: a two-faced genome guardian.

Georgakilas, A. G., Martin, O. A., & Bonner, W. M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.02.001 · Cited by 489 · see citing works

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

Zhan, Q., Antinore, M. J., Wang, X. W., Carrier, F., Smith, M. L., Harris, C. C., & Fornace, A. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202667 · Cited by 474 · see citing works

p53 regulates a G 2 checkpoint through cyclin B1

Innocente, S. A., Abrahamson, J., Cogswell, J. P., & Lee, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2147 · Cited by 435 · see citing works

Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway

Rouault, J.-P., Falette, N., Guéhenneux, F., Guillot, C., Rimokh, R., Wang, Q., Berthet, C., Moyret-Lalle, C., Savatier, P., Pain, B., et al. (1996) · Nature Genetics · doi:10.1038/ng1296-482 · Cited by 434 · see citing works

Curcumin induces apoptosis in human breast cancer cells through p53‐dependent Bax induction

Choudhuri, T., Pal, S., Agwarwal, M. L., Das, T., & Sa, G. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02292-5 · Cited by 430 · see citing works

Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

Dannenberg, J.-H., van Rossum, A., Schuijff, L., & te Riele, H. (2000) · Genes & Development · doi:10.1101/gad.847700 · Cited by 413 · see citing works

Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53

Ollmann, M. M., Young, L. M., Como, C. J. D., Karim, F. D., Belvin, M. P., Robertson, S., Whittaker, K. L., Demsky, M., Fisher, W. W., Buchman, A. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80626-1 · Cited by 413 · see citing works

PARP-1, a determinant of cell survival in response to DNA damage

Bouchard, V. J., Rouleau, M., & Poirier, G. G. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00083-3 · Cited by 390 · see citing works

Soy Isoflavones and Cancer Prevention

Sarkar, F. H., & Li, Y. (2003) · Cancer Investigation · doi:10.1081/cnv-120023773 · Cited by 385 · see citing works

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Hussain, S. P., Amstad, P., He, P., Robles, A. I., Lupold, S. E., Kaneko, I., Ichimiya, M., Sengupta, S., Mechanic, L. E., Okamura, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-2287-2 · Cited by 385 · see citing works

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

Huang, L. C., Clarkin, K. C., & Wahl, G. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4827 · Cited by 384 · see citing works

Maturation of human oocytes in vitro and their developmental competence

Trounson, A. O., Anderiesz, C., & Jones, G. (2001) · Reproduction · doi:10.1530/rep.0.1210051 · Cited by 378 · see citing works

A review on anti-cancer properties of Quercetin in breast cancer

Ezzati, M., Yousefi, B., Velaei, K., & Safa, A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117463 · Cited by 361 · see citing works

Expression of Wild-type p53 Is Required for Efficient Global Genomic Nucleotide Excision Repair in UV-irradiated Human Fibroblasts

Ford, J. M., & Hanawalt, P. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.28073 · Cited by 357 · see citing works

Inhibition of Cyclooxygenase-2 Gene Expression by p53

Subbaramaiah, K., Altorki, N. K., Chung, W. J., MESTRE, J. R., Sampat, A., & Dannenberg, A. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10911 · Cited by 350 · see citing works

Nuclear Accumulation of p21 Cip1 at the Onset of Mitosis: a Role at the G 2 /M-Phase Transition

Dulić, V., Stein, G. H., Far, D. F., & Reed, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.546 · Cited by 352 · see citing works

PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy

Mayo, L. D., Dixon, J. E., Durden, D. L., Tonks, N. K., & Donner, D. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108302200 · Cited by 351 · see citing works

Mechanisms involved in the inhibition of myoblast proliferation and differentiation by myostatin

Joulia-Ekaza, D., Bernardi, H., Garandel, V., Rabenoelina, F., Vernus, B., & Cabello, G. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00074-0 · Cited by 338 · see citing works

p53, cancer and the immune response

Blagih, J., Buck, M. D., & Vousden, K. H. (2020) · Journal of Cell Science · doi:10.1242/jcs.237453 · Cited by 333 · see citing works

p53 in signaling checkpoint arrest or apoptosis

Bates, S., & Vousden, K. H. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)90004-0 · Cited by 331 · see citing works

The p53 tumor suppressor participates in multiple cell cycle checkpoints

Giono, L. E., & Manfredi, J. J. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20689 · Cited by 326 · see citing works

Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis.

Park, W. H., Seol, J. G., Kim, E.-K., Hyun, J. M., Jung, C. W., Lee, C. R., Kim, B.-K., & Lee, Y. Y. (2000) · PubMed · Cited by 322 · see citing works

p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

Adimoolam, S., & Ford, J. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202485699 · Cited by 321 · see citing works

Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein

Li, Y., Upadhyay, S. K., Bhuiyan, M., & Sarkar, F. H. (1999) · Oncogene · doi:10.1038/sj.onc.1202650 · Cited by 320 · see citing works

Mechanisms of Cancer Chemoprevention by Soy Isoflavone Genistein

Sarkar, F. H., & Li, Y. (2002) · Cancer and Metastasis Reviews · doi:10.1023/a:1021210910821 · Cited by 319 · see citing works

Activation and activities of the p53 tumour suppressor protein

Bálint, É., & Vousden, K. H. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2128 · Cited by 310 · see citing works

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.Preprint

Wang, X. W., Vermeulen, W., Coursen, J. D., Gibson, M. K., Lupold, S. E., Forrester, K., Xu, G., Elmore, L. W., Yeh, H., Hoeijmakers, J. H. J., et al. (1996) · Genes & Development · doi:10.1101/gad.10.10.1219 · Cited by 311 · see citing works

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F.-M., Gagos, S., Tzetis, M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3378 · Cited by 308 · see citing works

The same, only different – DNA damage checkpoints and their reversal throughout the cell cycle

Shaltiël, I. A., Krenning, L., Bruinsma, W., & Medema, R. H. (2015) · Journal of Cell Science · doi:10.1242/jcs.163766 · Cited by 289 · see citing works

Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

Feng, J., Tamaskovic, R., Yang, Z., Brazil, D. P., Merlo, A., Hess, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404936200 · Cited by 294 · see citing works

The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control

Garkavtsev, I., Grigorian, I. A., Ossovskaya, V., Chernov, M. V., Chumakov, P. M., & Gudkov, A. V. (1998) · Nature · doi:10.1038/34675 · Cited by 291 · see citing works

Oncogenic <i>ras</i> and p53 Cooperate To Induce Cellular Senescence

Ferbeyre, G., de Stanchina, E., Lin, A. W., Querido, E., McCurrach, M. E., Hannon, G. J., & Lowe, S. W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3497-3508.2002 · Cited by 290 · see citing works

Control of the cell cycle and apoptosis

Weinberg, R. A., & Lundberg, A. S. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00046-5 · Cited by 288 · see citing works

COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective

Harris, C. C. (1996) · Carcinogenesis · doi:10.1093/carcin/17.6.1187 · Cited by 284 · see citing works

Control of the G2/M Transition

Stark, G. R., & Taylor, W. R. (2006) · Molecular Biotechnology · doi:10.1385/mb:32:3:227 · Cited by 279 · see citing works

Correction: Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature.

Barr, M. P., Gray, S. G., Hoffmann, A.-C., Hilger, R. A., Thomale, J., O’Flaherty, J. D., Fennell, D. A., Richard, D. J., O’Leary, J. J., & O'Byrne, K. J. (2020) · PubMed Central · doi:10.1371/journal.pone.0233739 · Cited by 269 · see citing works

Krüppel-like Factor 4 Mediates p53-dependent G1/S Cell Cycle Arrest in Response to DNA Damage

Yoon, H. S., Chen, X., & Yang, V. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211027200 · Cited by 266 · see citing works

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.Preprint

Minn, A. J., Boise, L., & Thompson, C. B. (1996) · Genes & Development · doi:10.1101/gad.10.20.2621 · Cited by 263 · see citing works

Cooperative effects of genes controlling the G2/M checkpointPreprint

Chan, T. A.-T., Hwang, P. M., Hermeking, H., Kinzler, K. W., & Vogelstein, B. (2000) · Genes & Development · doi:10.1101/gad.14.13.1584 · Cited by 262 · see citing works

Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control

Bartz, S. R., Rogel, M. E., & Emerman, M. (1996) · Journal of Virology · doi:10.1128/jvi.70.4.2324-2331.1996 · Cited by 251 · see citing works

Control of the cell cycle and apoptosis

Lundberg, A. S., & Weinberg, R. A. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00292-0 · Cited by 241 · see citing works

DNA damage and p53-mediated cell cycle arrest: A reevaluation

Pellegata, N. S., Antoniono, R. J., Redpath, J. L., & Stanbridge, E. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15209 · Cited by 229 · see citing works

Arrest of G ₁ -S Progression by the p53-Inducible Gene <i>PC3</i> Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription

Guardavaccaro, D., Corrente, G., Covone, F., Micheli, L., D'Agnano, I., Starace, G., Caruso, M., & Tirone, F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1797-1815.2000 · Cited by 230 · see citing works

The role of the tumor suppressor p53 in spermatogenesis

Beumer, T. L., Roepers‐Gajadien, H. L., Gademan, I. S., van Buul, P. P. W., Gil‐Gómez, G., Rutgers, D. H., & de Rooij, D. G. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400396 · Cited by 218 · see citing works

Radiation Response of Neural Precursor Cells: Linking Cellular Sensitivity to Cell Cycle Checkpoints, Apoptosis and Oxidative Stress

Limoli, C. L., Giedzinski, E., Rola, R., Otsuka, S., Palmer, T. D., & Fike, J. R. (2004) · Radiation Research · doi:10.1667/rr3112 · Cited by 213 · see citing works

Effect of flavonoids on cell cycle progression in prostate cancer cells

Kobayashi, T., Nakata, T., & Kuzumaki, T. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00738-8 · Cited by 214 · see citing works

GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity

Jin, S., Tong, T., Fan, W., Fan, F., Antinore, M. J., Zhu, X., Mazzacurati, L., Li, X., Petrik, K. L., Rajasekaran, B., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1206034 · Cited by 207 · see citing works

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53

Li, F., Igarashi, M., Leung, J., Sugrue, M. M., Lee, S. W., & Aaronson, S. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202615 · Cited by 207 · see citing works

p53‐inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG‐1

Matsuzawa, S., Takayama, S., Froesch, B. A., Zapata, J. M., & Reed, J. C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.10.2736 · Cited by 203 · see citing works

Activation of p53 by MDM2 Antagonists Can Protect Proliferating Cells from Mitotic Inhibitors

Carvajal, D. M., Tovar, C., Yang, H. S., Vu, B. T., Heimbrook, D. C., & Vassilev, L. T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3576 · Cited by 202 · see citing works

The GADD45 Inhibition of Cdc2 Kinase Correlates with GADD45-mediated Growth Suppression

Jin, S., Antinore, M. J., Lung, F. T., Dong, X. Z., Zhao, H., Fan, F., Colchagie, A. B., Blanck, P., Roller, P. P., Fornace, A. J., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000284200 · Cited by 202 · see citing works

Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer

Wang, W., Chen, T., Xu, H., Ren, B., Cheng, X., Qi, R., Liu, H., Wang, Y., Yan, L., Chen, S., et al. (2018) · Molecules · doi:10.3390/molecules23071578 · Cited by 198 · see citing works

Human DNA repair systems: An overview

Yu, Z., Chen, J., Ford, B. N., Brackley, M. E., & Glickman, B. W. (1999) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(1999)33:1 · Cited by 194 · see citing works

Analyzing the G2/M Checkpoint

Stark, G. R., & Taylor, W. R. (2004) · Humana Press eBooks · doi:10.1385/1-59259-788-2:051 · Cited by 195 · see citing works

Mechanisms of G2 Arrest in Response to Overexpression of p53

Taylor, W. R., DePrimo, S. E., Agarwal, A. M., Agarwal, M. L., Schönthal, A. H., Katula, K. S., & Stark, G. R. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3607 · Cited by 195 · see citing works

Cooperative Interactions Between RB and p53 Regulate Cell Proliferation, Cell Senescence, and Apoptosis in Human Vascular Smooth Muscle Cells From Atherosclerotic Plaques

Bennett, M. R., Macdonald, K., Chan, S., Boyle, J. J., & Weissberg, P. L. (1998) · Circulation Research · doi:10.1161/01.res.82.6.704 · Cited by 192 · see citing works

Survivin and p53 Modulate Quercetin-induced Cell Growth Inhibition and Apoptosis in Human Lung Carcinoma Cells

Kuo, P.-C., Liu, H.-F., & Chao, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407985200 · Cited by 190 · see citing works

The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy

Bristow, R. G., Benchimol, S., & Hill, R. P. (1996) · Radiotherapy and Oncology · doi:10.1016/0167-8140(96)01806-3 · Cited by 191 · see citing works

APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.

Robles, A. I., Bemmels, N. A., Foraker, A. B., & Harris, C. C. (2001) · PubMed · Cited by 190 · see citing works

Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells

Choi, E. J., Bae, S. M., & Ahn, W. S. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-001-2107-0 · Cited by 182 · see citing works

Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53

Albrechtsen, N., Dornreiter, I., Große, F., Kim, E. L., Wiesmüller, L., & Deppert, W. (1999) · Oncogene · doi:10.1038/sj.onc.1202952 · Cited by 181 · see citing works

p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition.

Vahteristo, P., Tamminen, A., Karvinen, P., Eerola, H., Eklund, C., Aaltonen, L. A., BLOMQVIST, C. P., Aittomäki, K., & Nevanlinna, H. A. (2001) · PubMed · Cited by 180 · see citing works

Radiation-Induced Senescence-like Growth Arrest Requires TP53 Function but not Telomere Shortening

Suzuki, K., Mori, I., Nakayama, Y., Miyakoda, M., Kodama, S., & Watanabe, M. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0248:rislga]2.0.co;2 · Cited by 176 · see citing works

Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death.

Barnes, B. J., Kellum, M. J., Pinder, K. E., Frisancho, J. A., & Pitha, P. M. (2003) · PubMed · Cited by 175 · see citing works

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

Duckett, D. R., Bronstein, S. M., Taya, Y., & Modrich, P. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12384 · Cited by 177 · see citing works

Antitopoisomerase drug action and resistance

Nitiss, J. L., & Beck, W. T. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(96)00056-1 · Cited by 177 · see citing works

Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S

Lu, M., & Shenk, T. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8850-8857.1996 · Cited by 175 · see citing works

p53 and chemosensitivity

Ferreira, C. G., Tolis, C., & Giaccone, G. (1999) · Annals of Oncology · doi:10.1023/a:1008361818480 · Cited by 174 · see citing works

Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells

Zheng, P.-W., Chiang, L., & Lin, C. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.08.023 · Cited by 173 · see citing works

Antitumor Activity of NVP-BKM120—A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells

Koul, D., Fu, J., Shen, R., LaFortune, T. A., Wang, S., Tiao, N., Kim, Y., Liu, J.-L., Ramnarian, D., Yuan, Y., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1558 · Cited by 172 · see citing works

p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein

Gottifredi, V., Karni-Schmidt, O., Shieh, S.-Y., & Prives, C. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1066-1076.2001 · Cited by 174 · see citing works

Mutations in the p53 and SCID genes cooperate in tumorigenesis.Preprint

Nacht, M., Strasser, A., Chan, Y. R., Harris, A. W., Schlissel, M. S., Bronson, R. T., & Jacks, T. (1996) · Genes & Development · doi:10.1101/gad.10.16.2055 · Cited by 171 · see citing works

Ablation of either p21 or Bax prevents p53‐dependent apoptosis induced by green tea polyphenol epigallocatechin‐3‐gallate

Hastak, K., Agarwal, M. K., Mukhtar, H., & Agarwal, M. L. (2005) · The FASEB Journal · doi:10.1096/fj.04-2226fje · Cited by 171 · see citing works

Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation

Rapić-Otrin, V. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2588 · Cited by 171 · see citing works

DNA damage and p53-mediated cell cycle arrest: A reevaluation

Pellegata, N. S., Antoniono, R. J., Redpath, J. L., & Stanbridge, E. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15209 · Cited by 229 · see citing works

S phase cell-cycle arrest following DNA damage is independent of the p53/p21(WAF1) signalling pathway.

Wyllie, F. S., Haughton, M. F., BOND, J. A., Rowson, J. M., Jones, C. J., & Wynford‐Thomas, D. (1996) · PubMed · Cited by 32 · see citing works

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

Waldman, T. A., Kinzler, K. W., & Vogelstein, B. (1995) · PubMed · Cited by 1,203 · see citing works

p53-Dependent Signaling in Response to DNA Damage or Arrest of DNA Synthesis and its Role in Cell Cycle Control

Agarwal, M. L., Taylor, W. R., & Stark, G. R. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5365-6_5 · Cited by 1 · see citing works

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Di Leonardo, A., Linke, S. P., Clarkin, K., & Wahl, G. M. (1994) · Genes &amp; Development · doi:10.1101/gad.8.21.2540 · Cited by 1,215 · see citing works