The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
Open accessAbstract
Cdc6 has a critical regulatory role in the initiation of DNA replication in yeasts, but its function in mammalian cells has not been characterized. We show here that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues of intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. Immunodepletion of Cdc6 by microinjection of anti-Cdc6 antibody blocks initiation of DNA replication in a human tumor cell line. We conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.
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Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
Cited by
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317
Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0030 · Cited by 1,527
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A
Meraldi, P., Lukas, J., Fry, A. M., Bartek, J., & Nigg, E. A. (1999) · Nature Cell Biology · doi:10.1038/10054 · Cited by 475
Davis, A. J., Yan, Z., Martinez, B., & Mumby, M. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710313200 · Cited by 45
Self-citationEelen, G., Vanden Bempt, I., Verlinden, L., Drijkoningen, M., Smeets, A., Neven, P., Christiaens, M. R., Marchal, K., Bouillon, R., & Verstuyf, A. (2008) · Oncogene · doi:10.1038/onc.2008.51 · Cited by 41
The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene
van Kempen, L. C. L., Redpath, M., Elchebly, M., Klein, K. O., Papadakis, A. I., Wilmott, J. S., Scolyer, R. A., Edqvist, P.-H., Pontén, F., Schadendorf, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aai9188 · Cited by 29
Role of Cdc6 in re-replication in cells expressing human papillomavirus E7 oncogene
Fan, X., Zhou, Y., & Chen, J. J. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw059 · Cited by 9
Metadata
- Authors
- Yan, Z., DeGregori, J., Shohet, R., Leone, G., Stillman, B., Nevins, J. R., & Williams, R. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-03-31
- Volume
- 95
- Issue
- 7
- Pages
- 3603-3608
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052381578
- Cited by
- 266
- References
- 2
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
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