Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit

DNA Replication in Eukaryotic Cells

Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,065 · see citing works

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530417 · Cited by 1,890 · see citing works

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/bj3530417 · Cited by 1,392 · see citing works

Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

Méndez, J., & Stillman, B. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.22.8602-8612.2000 · Cited by 918 · see citing works

CRYSTAL STRUCTURES OF THE HELIX-LOOP-HELIX CALCIUM-BINDING PROTEINS

Strynadka, N. C. J., & James, M. N. G. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.004511 · Cited by 854 · see citing works

Detection of Calcium Binding Proteins by 45Ca Autoradiography on Nitrocellulose Membrane after Sodium Dodecyl Sulfate Gel Electrophoresis1

Maruyama, K., Mikawa, T., & EBASHl, S. (1984) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a134633 · Cited by 769 · see citing works

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation

Sontag, E., Fedorov, S. A., Kamibayashi, C., Robbins, D. J., Cobb, M. H., & Mumby, M. C. (1993) · Cell · doi:10.1016/0092-8674(93)90533-v · Cited by 510 · see citing works

The anaphase-promoting complex: it's not just for mitosis any morePreprint

Harper, J. W., Burton, J. L., & Solomon, M. J. (2002) · Genes & Development · doi:10.1101/gad.1013102 · Cited by 490 · see citing works

Structural Basis for the Interaction between FxFG Nucleoporin Repeats and Importin-β in Nuclear Trafficking

Bayliss, R., Littlewood, T. D., & Stewart, M. (2000) · Cell · doi:10.1016/s0092-8674(00)00014-3 · Cited by 464 · see citing works

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A., & Barford, D. (1999) · Cell · doi:10.1016/s0092-8674(00)80963-0 · Cited by 442 · see citing works

Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization

Petersen, B. O., Lukas, J., Sørensen, C. S., Bartek, J., & Helin, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.2.396 · Cited by 431 · see citing works

Regulation of Early Events in Chromosome Replication

Diffley, J. F. X. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.019 · Cited by 388 · see citing works

CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.

Mailand, N., & Diffley, J. (2005) · Cell · doi:10.1016/j.cell.2005.08.013 · Cited by 373 · see citing works

Protein phosphatase 2A: a panoply of enzymes

Virshup, D. M. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00074-5 · Cited by 330 · see citing works

Cell cycle– and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1Preprint

Petersen, B. O., Wagener, C., Marinoni, F., Kramer, E. R., Melixetian, M. B., Denchi, E. L., Gieffers, C., Matteucci, C., Peters, J., & Helin, K. (2000) · Genes & Development · doi:10.1101/gad.832500 · Cited by 277 · see citing works

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

Silverstein, A. M., Barrow, C. A., Davis, A. J., & Mumby, M. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072071699 · Cited by 276 · see citing works

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

Yan, Z., DeGregori, J. V., Shohet, R. V., Leone, G. W., Stillman, B., Nevins, J. R., & Williams, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3603 · Cited by 268 · see citing works

GLFG and FxFG Nucleoporins Bind to Overlapping Sites on Importin-β

Bayliss, R. W., Littlewood, T. D., Strawn, L. A., Wente, S. R., & Stewart, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209037200 · Cited by 213 · see citing works

Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

Jiang, W. B., Wells, N. J., & Hunter, T. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6193 · Cited by 211 · see citing works

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activationPreprint

Ali, A., Zhang, J., Bao, S., Liu, I., Otterness, D. M., Dean, N. M., Abraham, R. T., & Wang, X.-F. (2004) · Genes & Development · doi:10.1101/gad.1176004 · Cited by 170 · see citing works

A human protein related to yeast Cdc6p

Williams, R. S., Shohet, R. V., & Stillman, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.142 · Cited by 152 · see citing works

B56-Associated Protein Phosphatase 2A Is Required For Survival and Protects from Apoptosis in Drosophila melanogaster

Li, X., Scuderi, A., Letsou, A., & Virshup, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3674-3684.2002 · Cited by 135 · see citing works

Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process

Coverley, D., Pelizon, C., Trewick, S. C., et al. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1929 · Cited by 130 · see citing works

PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells

Yan, Z., Fedorov, S. A., Mumby, M. C., & Williams, R. S. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1021-1029.2000 · Cited by 119 · see citing works

The B″/PR72 subunit mediates Ca 2+ -dependent dephosphorylation of DARPP-32 by protein phosphatase 2A

Ahn, J., Sung, J. Y., McAvoy, T., Nishi, A., Janssens, V., Goris, J., Greengard, P., & Nairn, A. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703589104 · Cited by 102 · see citing works

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

Voorhoeve, P. M., Hijmans, E. M., & Bernards, R. (1999) · Oncogene · doi:10.1038/sj.onc.1202316 · Cited by 101 · see citing works

Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B″/PR72 subunit of protein phosphatase 2A

Janssens, V., Jordens, J., Stevens, I., Van Hoof, C., Martens, E., De Smedt, H., Engelborghs, Y., Waelkens, E., & Goris, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211717200 · Cited by 89 · see citing works

Multiple Mechanisms Regulate Subcellular Localization of Human CDC6

Delmolino, L. M., Saha, P., & Dutta, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101870200 · Cited by 88 · see citing works

Protein Phosphatase 2A Holoenzyme Assembly

Strack, S., Ruediger, R., Walter, G., Dagda, R. K., Barwacz, C. A., & Cribbs, J. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202992200 · Cited by 83 · see citing works

Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A

Li, X., & Virshup, D. M. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02680.x · Cited by 83 · see citing works

Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cyclePreprint

Pelizon, C., Madine, M. A., Romanowski, P., et al. (2000) · Genes & Development · doi:10.1101/gad.176300 · Cited by 79 · see citing works

p53-Dependent Regulation of Cdc6 Protein Stability Controls Cellular Proliferation

Duursma, A. M., & Agami, R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.6937-6947.2005 · Cited by 77 · see citing works

PR72, a novel regulator of Wnt signaling required for Naked cuticle functionPreprint

Creyghton, M. P., Roël, G., Eichhorn, P. J. A., Hijmans, E. M., Maurer, I., Destrée, O., & Bernards, R. (2005) · Genes & Development · doi:10.1101/gad.328905 · Cited by 74 · see citing works

Cdc6 Chromatin Affinity Is Unaffected by Serine-54 Phosphorylation, S-Phase Progression, and Overexpression of Cyclin A

Alexandrow, M. G., & Hamlin, J. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1614-1627.2004 · Cited by 73 · see citing works

Structural characterization of cardiac protein phosphatase with a monoclonal antibody. Evidence that the Mr = 38,000 phosphatase is the catalytic subunit of the native enzyme(s).

Mumby, M. C., Green, D. D., & Russell, K. L. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38791-4 · Cited by 56 · see citing works

PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle

Creyghton, M. P., Roël, G., Eichhorn, P. J. A., Vredeveld, L. C. W., Destrée, O., & Bernards, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507237103 · Cited by 46 · see citing works

Cyclic AMP Selectively Uncouples Mitogen-Activated Protein Kinase Cascades from Activating Signals

Pearson, G. W., Earnest, S. A., & Cobb, M. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3039-3047.2006 · Cited by 41 · see citing works

Mutation of Cyclin/cdk Phosphorylation Sites in HsCdc6 Disrupts a Late Step in Initiation of DNA Replication in Human Cells

Herbig, U., Griffith, J. W., & Fanning, E. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4117 · Cited by 32 · see citing works

Identification and characterization of B′′‐subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues

Stevens, I., Janssens, V., Martens, E., Dilworth, S., Goris, J., & HOOF, C. V. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03398.x · Cited by 22 · see citing works

Protein Phosphatase 2A

Silverstein, A. M., Davis, A. J., Bielinski, V. A., Esplin, E. D., Mahmood, N. A., & Mumby, M. C. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50550-7 · Cited by 1 · see citing works

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

Sents, W., Ivanova, E., Lambrecht, C., Haesen, D., & Janssens, V. (2013) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08579.x · Cited by 204 · see citing works

Structure, Regulation, and Pharmacological Modulation of PP2A Phosphatases

Lambrecht, C., Haesen, D., Sents, W., Ivanova, E., & Janssens, V. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-562-0_17 · Cited by 140 · see citing works

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer

(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2019.03.009 · Cited by 93 · see citing works

Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation

Wlodarchak, N., Guo, F., Satyshur, K. A., Jiang, L., Jeffrey, P. D., Sun, T., Stanevich, V., Mumby, M. C., & Xing, Y. (2013) · Cell Research · doi:10.1038/cr.2013.77 · Cited by 72 · see citing works

The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene

van Kempen, L. C. L., Redpath, M., Elchebly, M., Klein, K. O., Papadakis, A. I., Wilmott, J. S., Scolyer, R. A., Edqvist, P.-H., Pontén, F., Schadendorf, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aai9188 · Cited by 29 · see citing works

Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B″ subunits of protein phosphatase 2A

Zwaenepoel, K., Louis, J. V., Goris, J., & Janssens, V. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-393 · Cited by 30 · see citing works

Targeting PP2A in cancer: an underrated option

Sarais, F., Krempien, F., Koehn, C., Brewing, L., Classen, C. F., Walter, M., & Shokraie, O. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03560-y · Cited by 8 · see citing works

Phosphatase Control by Methylation

(2001) · Science s STKE · doi:10.1126/stke.2001.67.tw3

Generation of Active Protein Phosphatase 2A Is Coupled to Holoenzyme Assembly

Hombauer, H., Weismann, D., Mudrak, I., Stanzel, C., Fellner, T., Lackner, D. H., & Ogris, E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050155 · Cited by 88 · see citing works

AlphaFold-Multimer (v3) model of a complex of Protein Phosphatase 2A catalytic subunit (PP2A/C), PP2A scaffold subunit (PP2A/A), the B55alpha substrate binding subunit, and FAM122A, a PP2A inhibitor protein.

Faezov, B., Dunbrack, R. L., & Graña, X. (2023) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.7739038

AlphaFold-Multimer (v3) model of a complex of Protein Phosphatase 2A catalytic subunit (PP2A/C), PP2A scaffold subunit (PP2A/A), the B55alpha substrate binding subunit, and FAM122A, a PP2A inhibitor protein.

Faezov, B., Dunbrack, R. L., & Graña, X. (2023) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.7739037

Structural Basis of PP2A Inhibition by Small t Antigen

Cho, U., Morrone, S. R., Sablina, A. A., Arroyo, J. D., Hahn, W. C., & Xu, W. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050202 · Cited by 124 · see citing works