The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS
Open accessAbstract
HIV type 1 (HIV-1) not only directly kills infected CD4+T cells but also induces immunosuppression of uninfected T cells. Two immunosuppressive proteins, interferon α (IFNα) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells in HIV-1-infected peripheral blood mononuclear cell cultures. Furthermore, the production of C-C chemokines in response to immune cell activation, initially enhanced by IFNα and Tat, ultimately is inhibited by these proteins in parallel with their induction of immunosuppression. The clinical corollary is the immunosuppression of uninfected T cells and the decline in C-C chemokine release found at advanced stages of HIV-1 infection paralleling rising levels of IFNα and extracellular Tat. We, therefore, suggest that IFNα and Tat may be critical targets for anti-AIDS strategies.
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Cites
T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 + T Cell Turnover
Wolthers, K. C., Bea, G., Wisman, A., Otto, S. A., de Roda Husman, A.-M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R. A., van der Zee, A. G. J., et al. (1996) · Science · doi:10.1126/science.274.5292.1543 · Cited by 286
Cited by
Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
Cafaro, A., Caputo, A., Fracasso, C., Maggiorella, M. T., Goletti, D., Baroncelli, S., Pace, M., Sernicola, L., Koanga-Mogtomo, M. L., Betti, M., et al. (1999) · Nature Medicine · doi:10.1038/9488 · Cited by 276
The function of type I interferons in antimicrobial immunity
Bogdan, C. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00111-4 · Cited by 276
Interfering with immunity: detrimental role of type I IFNs during infection
Stifter, S. A., & Feng, C. G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402794 · Cited by 78
Lanna, A., Coutavas, E., Levati, L., Seidel, J., Rustin, M. H. A., Henson, S. M., Akbar, A. N., & Franzese, O. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301409 · Cited by 62
Metadata
- Authors
- Zagury, D., Lachgar, A., Chams, V., Fall, L. S., Bernard, J., Zagury, J.-F., Bizzini, B., Gringeri, A., Santagostino, E., Rappaport, J., Feldman, M., Burny, A., & Gallo, R. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-03-31
- Volume
- 95
- Issue
- 7
- Pages
- 3851-3856
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1996600503
- Cited by
- 172
- References
- 1
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS. https://app.cochat.ai/papers/10.1073/pnas.95.7.3851
- The paper
- Zagury, D., Lachgar, A., Chams, V., Fall, L. S., Bernard, J., Zagury, J.-F., Bizzini, B., Gringeri, A., Santagostino, E., Rappaport, J., Feldman, M., Burny, A., & Gallo, R. C. (1998). Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.7.3851
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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