Interfering with immunity: detrimental role of type I IFNs during infection
Abstract
Type I IFNs are known to inhibit viral replication and mediate protection against viral infection. However, recent studies revealed that these cytokines play a broader and more fundamental role in host responses to infections beyond their well-established antiviral function. Type I IFN induction, often associated with microbial evasion mechanisms unique to virulent microorganisms, is now shown to increase host susceptibility to a diverse range of pathogens, including some viruses. This article presents an overview of the role of type I IFNs in infections with bacterial, fungal, parasitic, and viral pathogens and discusses the key mechanisms mediating the regulatory function of type I IFNs in pathogen clearance and tissue inflammation.
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Traditionally, Type I IFN response was considered solely for defense against viral and bacterial infections.
“Traditionally, Type I IFN response was considered solely for defense against viral and bacterial infections (Stifter and Feng, 2015)(Kovarik et al., 2016).”
From TET2 Regulates the Neuroinflammatory Response in Microglia (2019) · cites this paper as Stifter and Feng, 2015
Cites
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062 · see citing works
Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · see citing works
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · see citing works
Growth of Candida albicans hyphae
Sudbery, P. E. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2636 · Cited by 1,110 · see citing works
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
Fernandes-Alnemri, T., Yu, J.-W., Juliana, C., Solorzano, L., Kang, S., Wu, J., Datta, P., McCormick, M., Huang, L., McDermott, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1859 · Cited by 732 · see citing works
The co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722 · see citing works
Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity
Haller, O., & Kochs, G. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.31003.x · Cited by 460 · see citing works
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
Levy, D. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00027-7 · Cited by 428 · see citing works
Mayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A. (2011) · Immunity · doi:10.1016/j.immuni.2011.12.002 · Cited by 418 · see citing works
Self-citationNeutrophils in innate host defense against Staphylococcus aureus infections
Rigby, K. M., & DeLeo, F. R. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0295-3 · Cited by 400 · see citing works
Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice.
Kudva, A., Scheller, E. V., Robinson, K. M., Crowe, C. R., Choi, S. M., Slight, S. R., Khader, S. A., Dubin, P. J., Enelow, R. I., Kolls, J. K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002194 · Cited by 346 · see citing works
Lazear, H. M., Lancaster, A., Wilkins, C., Suthar, M. S., Huang, A., Vick, S. C., Clepper, L., Thackray, L., Brassil, M. M., Virgin, H. W., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003118 · Cited by 296 · see citing works
Nakamura, S., Davis, K. M., & Weiser, J. N. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57762 · Cited by 280 · see citing works
Dockrell, D. H., Marriott, H. M., Prince, L. R., Ridger, V. C., Ince, P. G., Hellewell, P. G., & Whyte, M. K. B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5380 · Cited by 239 · see citing works
Bourgeois, C., Majer, O., Frohner, I. E., Lesiak-Markowicz, I., Hildering, K.-S., Glaser, W., Stockinger, S., Decker, T., Akira, S., Müller, M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002599 · Cited by 116 · see citing works
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Bradley, K. C., Finsterbusch, K., Schnepf, D., Crotta, S., Llorian, M., Davidson, S., Fuchs, S. Y., Staeheli, P., & Wack, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.105 · Cited by 313 · see citing works
TET2 Regulates the Neuroinflammatory Response in Microglia
Carrillo-Jimenez, A., Deniz, Ö., Niklison-Chirou, M. V., Ruiz, R., Bezerra-Salomão, K., Stratoulias, V., Amouroux, R., Yip, P. K., Vilalta, A., Cheray, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.013 · Cited by 104 · see citing works
Riedelberger, M., Penninger, P., Tscherner, M., Hadriga, B., Brunnhofer, C., Jenull, S., Stoiber, A., Bourgeois, C., Petryshyn, A., Glaser, W., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101121 · Cited by 23 · see citing works
- Authors
- Stifter, S. A., & Feng, C. G.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Feng, Carl G
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03
- Volume
- 194
- Issue
- 6
- Pages
- 2455-2465
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1847932158
- Cited by
- 78
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 11 · 2017: 9 · 2016: 14 · 2015: 6
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- type I interferon, host susceptibility to infection, bacterial infection, fungal infection, parasitic infection, viral infection, pathogen clearance, tissue inflammation, antiviral immunity
- MeSH terms
- Humans, Immunity, Infections, Interferon Type I, Signal Transduction, Cytokines, Receptor, Interferon alpha-beta, Host-Pathogen Interactions, Disease Resistance
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