The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The yeast CLC chloride channel functions in cation homeostasis
Open accessAbstract
A defect in the yeast GEF1 gene, a CLC chloride channel homolog leads to an iron requirement and cation sensitivity. The iron requirement is due to a failure to load Cu 2+ onto a component of the iron uptake system, Fet3. This process, which requires both Gef1 and the Menkes disease Cu 2+ -ATPase yeast homolog Ccc2, occurs in late- or post-Golgi vesicles, where Gef1 and Ccc2 are localized. The defects of gef1 mutants can be suppressed by the introduction of Torpedo marmorata CLC-0 or Arabidopsis thaliana CLC-c and -d chloride channel genes. The functions of Gef1 in cation homeostasis provide clues to the understanding of diseases caused by chloride channel mutations in humans and cation toxicity in plants.
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Cites
A permease-oxidase complex involved in high-affinity iron uptake in yeast.
Stearman, R., Yuan, D. S., Yamaguchi-Iwai, Y., Klausner, R. D., & Dancis, A. (1996) · Science · doi:10.1126/science.271.5255.1552 · Cited by 683
Self-citationThe FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.
Askwith, C., Eide, D., Van Ho, A., Bernard, P. S., Li, L., Davis-Kaplan, S., Sipe, D. M., & Kaplan, J. (1994) · Cell · doi:10.1016/0092-8674(94)90346-8 · Cited by 670
Kennedy, B. K., Gotta, M., Sinclair, D. A., Mills, K., McNabb, D. S., Murthy, M., Pak, S. M., Laroche, T., Gasser, S. M., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80219-6 · Cited by 375
Cited by
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995
Drought- and salt-tolerant plants result from overexpression of the AVP1 H + -pump
Gaxiola, R. A., Li, J., Undurraga, S., Dang, L. M., Allen, G. J., Alper, S. L., & Fink, G. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191389398 · Cited by 746
Self-citationMitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation
Tovar, J., León-Avila, G., Sánchez, L. B., Sutak, R., Tachezy, J., van der Giezen, M., Hernández, M., Müller, M., & Lucocq, J. M. (2003) · Nature · doi:10.1038/nature01945 · Cited by 608
Stobrawa, S. M., Breiderhoff, T., Takamori, S., Engel, D., Schweizer, M., Zdebik, A. A., Bösl, M. R., Ruether, K., Jahn, H., Draguhn, A., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00189-1 · Cited by 508
Metadata
- Authors
- Gaxiola, R. A., Yuan, D. S., Klausner, R. D., & Fink, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-03-31
- Volume
- 95
- Issue
- 7
- Pages
- 4046-4050
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2105404023
- Cited by
- 175
- References
- 3
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Gaxiola, R. A., Yuan, D. S., Klausner, R. D., & Fink, G. R. (1998). The yeast CLC chloride channel functions in cation homeostasis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.7.4046
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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