The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Placental failure in mice lacking the homeobox gene Dlx 3
Open accessAbstract
Dlx3 is a homeodomain transcription factor and a member of the vertebrate Distal-less family. Targeted deletion of the mouse Dlx3 gene results in embryonic death between day 9.5 and day 10 because of placental defects that alter the development of the labyrinthine layer. In situ hybridization reveals that the Dlx3 gene is initially expressed in ectoplacental cone cells and chorionic plate, and later in the labyrinthine trophoblast of the chorioallantoic placenta, where major defects are observed in the Dlx3 −/− embryos. The expression of structural genes, such as 4311 and PL-1 , which were used as markers to follow the fate of different derivatives of the placenta, was not affected in the Dlx3 -null embryos. However, by day 10.5 of development, expression of the paired-like homeodomain gene Esx1 was strongly down-regulated in affected placenta tissue, suggesting that Dlx3 is required for the maintenance of Esx1 expression, normal placental morphogenesis, and embryonic survival.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Cited by
Cranial neural crest and the building of the vertebrate head
Santagati, F., & Rijli, F. M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1221 · Cited by 461
Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development
Depew, M. J., Simpson, C. A., Morasso, M., & Rubenstein, J. L. R. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00487.x · Cited by 296
Self-citationEctodermal dysplasias: not only ‘skin’ deep
Priolo, M., Silengo, M., Lerone, M., & Ravazzolo, R. (2000) · Clinical Genetics · doi:10.1034/j.1399-0004.2000.580601.x · Cited by 106
Yang, F., Huang, L., Tso, A., Wang, H., Cui, L., Lin, L., Wang, X., Ren, M., Fang, X., Liu, J., et al. (2020) · PLOS Genetics · doi:10.1371/journal.pgen.1008739 · Cited by 31
Metadata
- Authors
- Morasso, M. I., Grinberg, A., Robinson, G., Sargent, T. D., & Mahon, K. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-01-05
- Volume
- 96
- Issue
- 1
- Pages
- 162-167
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2120162279
- Cited by
- 254
- References
- 1
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Placental failure in mice lacking the homeobox gene Dlx 3. https://app.cochat.ai/papers/10.1073/pnas.96.1.162
- The paper
- Morasso, M. I., Grinberg, A., Robinson, G., Sargent, T. D., & Mahon, K. A. (1999). Placental failure in mice lacking the homeobox gene Dlx 3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.1.162
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
