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Cited by 594

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

Open access
Yeh, Shuyuan, Lin, Hui-Kuan, Kang, Hong-Yo, Thin, Tin Htwe, Lin, Ming-Fong, Chang, Chawnshang·1999·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.96.10.5458
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Abstract

Overexpression of the HER2 / Neu protooncogene has been linked to the progression of breast cancer. Here we demonstrate that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2 / Neu . Using AG879, a HER2/Neu inhibitor, and PD98059, a MAP kinase inhibitor, as well as MAP kinase phosphatase-1 (MPK-1), in the transfection assay, we found that HER2/Neu could induce prostate-specific antigen (PSA), a marker for the progression of prostate cancer, through the MAP kinase pathway at a low androgen level. Reporter assays and mammalian two-hybrid assays further suggest this HER2/Neu-induced androgen receptor (AR) transactivation may function through the promotion of interaction between AR and AR coactivators, such as ARA70. Furthermore, we found this HER2/Neu → MAP kinase → AR-ARAs → PSA pathway could not be blocked completely by hydroxyflutamide, an antiandrogen used in the treatment of prostate cancer. Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients.

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Metadata

Authors
Yeh, S., Lin, H.-K., Kang, H.-Y., Thin, T. H., Lin, M.-F., & Chang, C.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1999-05-11
Volume
96
Issue
10
Pages
5458-5463
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.96.10.5458
OpenAlex
W1985827132
Cited by
594
References
1
FWCI
39.15
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. https://app.cochat.ai/papers/10.1073/pnas.96.10.5458
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Yeh, S., Lin, H.-K., Kang, H.-Y., Thin, T. H., Lin, M.-F., & Chang, C. (1999). From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.10.5458

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.