Androgen Receptor in Prostate Cancer

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ <i>neu</i> Oncogene

Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760 · see citing works

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works

The retinoblastoma protein and cell cycle control

Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862 · see citing works

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785 · see citing works

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 4,557 · see citing works

Epidermal growth factor-related peptides and their receptors in human malignancies.

Salomon, D., Brandt, R., Ciardiello, F., & Normanno, N. (1995) · Critical reviews in oncology/hematology · doi:10.1016/1040-8428(94)00144-i · Cited by 2,860 · see citing works

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

Spada, A. L., Wilson, E. M., Lubahn, D. B., Harding, A., & Fischbeck, K. (1991) · Nature · doi:10.1038/352077a0 · Cited by 2,801 · see citing works

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551 · see citing works

The ErbB signaling network: receptor heterodimerization in development and cancer

Olayioye, M. A., Neve, R. M., Lane, H. A., & Hynes, N. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3159 · Cited by 2,438 · see citing works

The development of androgen-independent prostate cancer.

Feldman, B. J., & Feldman, D. (2001) · Nature reviews. Cancer · doi:10.1038/35094009 · Cited by 2,326 · see citing works

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974 · see citing works

Nuclear Receptor Coregulators: Cellular and Molecular Biology

McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0366 · Cited by 1,905 · see citing works

Risks of cancer in BRCA1-mutation carriers

FORD, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91578-4 · Cited by 1,850 · cited 6× · see citing works

Controlling TGF-beta signaling.

Massagué, J., & Chen, Y. (2000) · PubMed · Cited by 1,780 · see citing works

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

Anzick, S. L., Kononen, J., Walker, R. L., Azorsa, D. O., Tanner, M., Guan, X., Sauter, G., Kallioniemi, O., Trent, J. M., & Meltzer, P. S. (1997) · Science · doi:10.1126/science.277.5328.965 · Cited by 1,630 · see citing works

Controlling TGF-β signalingPreprint

Massagué, J., & Chen, Y. (2000) · Genes & Development · doi:10.1101/gad.14.6.627 · Cited by 1,571 · see citing works

Pten is essential for embryonic development and tumour suppression

Cristofano, A. D., Pesce, B., Cordon‐Cardo, C., & Pandolfi, P. P. (1998) · Nature Genetics · doi:10.1038/1235 · Cited by 1,518 · see citing works

In vivo amplification of the androgen receptor gene and progression of human prostate cancer

Visakorpi, T., Hyytinen, E., Koivisto, P., Tanner, M., Keinänen, R., Palmberg, C., Palotie, A., Tammela, T., Isola, J., & Kallioniemi, O.-P. (1995) · Nature Genetics · doi:10.1038/ng0495-401 · Cited by 1,484 · see citing works

Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives*

Quigley, C. A., Bellis, A. D., Marschke, K. B., Awady, M. K. E., Wilson, E. M., & French, F. S. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-271 · Cited by 1,436 · see citing works

Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups

Edwards, A., Hammond, H. A., Li, J., Caskey, C. T., & Chakraborty, R. (1992) · Genomics · doi:10.1016/0888-7543(92)90371-x · Cited by 1,426 · see citing works

Mutation of the Androgen-Receptor Gene in Metastatic Androgen-Independent Prostate Cancer

Taplin, M., Bubley, G. J., Shuster, T. D., Frantz, M. E., Spooner, A. E., Ogata, G. K., Keer, H. N., & Balk, S. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505253322101 · Cited by 1,243 · see citing works

The Multiple Roles of PTEN in Tumor Suppression

Di Cristofano, A., & Pandolfi, P. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80674-1 · Cited by 1,182 · see citing works

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors

Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163 · see citing works

The Rb/E2F pathway: expanding roles and emerging paradigms

Harbour, J. W., & Dean, D. C. (2000) · Genes &amp; Development · doi:10.1101/gad.813200 · Cited by 1,153 · see citing works

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function

Chamberlain, N. L., Driver, E. D., & Miesfeld, R. L. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.3181 · Cited by 1,149 · see citing works

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

Zimmermann, S., & Moelling, K. (1999) · Science · doi:10.1126/science.286.5445.1741 · Cited by 1,088 · see citing works

Increasing complexity of Ras signaling

Campbell, S. L., Khosravi-Far, R., Rossman, K. L., Clark, G. J., & Der, C. J. (1998) · Oncogene · doi:10.1038/sj.onc.1202174 · Cited by 1,079 · see citing works

The Endocrinology and Developmental Biology of the Prostate*

Cunha, G. R., Donjacour, A. A., Cooke, P. S., MEE, H., Bigsby, R. M., HIGGINS, S. J., & Sugimura, Y. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-3-338 · Cited by 1,036 · see citing works

Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome

Lubahn, D. B., JOSEPH, D. R., Sullivan, P. M., Willard, H. F., French, F. S., & Wilson, E. M. (1988) · Science · doi:10.1126/science.3353727 · Cited by 1,003 · see citing works

TNM classification of malignant tumors, fifth edition (1997)

Sobin, L. H., & Fleming, I. D. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19971101)80:9 · Cited by 996 · see citing works

Multiple Actions of Steroid Hormones—A Focus on Rapid, Nongenomic Effects

Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., & Wehling, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01468-6 · Cited by 986 · see citing works

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase

Craft, N., Shostak, Y., Carey, M., & Sawyers, C. L. (1999) · Nature Medicine · doi:10.1038/6495 · Cited by 980 · see citing works

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

Stahl, N., Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., et al. (1994) · Science · doi:10.1126/science.8272873 · Cited by 979 · see citing works

The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*

MENDEL, C. M. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-232 · Cited by 961 · see citing works

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

Đikić, I., Tokiwa, G. Y., Lev, S., Courtneidge, S. A., & Schlessinger, J. (1996) · Nature · doi:10.1038/383547a0 · Cited by 955 · see citing works

A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens

Veldscholte, J., Ris‐Stalpers, C., Kuiper, G. G. J. M., Jenster, G. W., Berrevoets, C., Claassen, E., van Rooij, H. C. J., Trapman, J., Brinkmann, A. O., & Mulder, E. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80067-1 · Cited by 945 · see citing works

Androgen Receptor (AR) Coregulators: An Overview

Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943 · see citing works

Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.

Čulig, Z., Hobisch, A., Cronauer, M. V., Radmayr, C., Trapman, J., Hittmair, A., Bartsch, G., & Klocker, H. (1994) · PubMed · Cited by 938 · see citing works

Molecular Cloning of Human and Rat Complementary DNA Encoding Androgen Receptors

Chang, C. S., Kokontis, J. M., & Liao, S. (1988) · Science · doi:10.1126/science.3353726 · Cited by 891 · see citing works

The CAG repeat within the androgen receptor gene and its relationship to prostate cancer

Giovannucci, E. L., Stampfer, M. J., Krithivas, K., Brown, M. A., Brufsky, A., Talcott, J. A., Hennekens, C. H., & Kantoff, P. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3320 · Cited by 872 · see citing works

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

Khandwala, H. M., McCutcheon, I. E., Flyvbjerg, A., & Friend, K. E. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.3.0399 · Cited by 842 · see citing works

Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials

Dalesio, O., van Tinteren, H., Clarke, M., Peto, R., Schroder, F., Dechering, I., Evans, V., Godwin, J., Blumenstein, B., Crawford, E., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02163-2 · Cited by 815 · see citing works

The serum transport of steroid hormones

SIITERI, P. K., MURAI, J. T., RAYMOURE, W. J., KUHN, R. W., HAMMOND, G. L., & NISKER, J. A. (1982) · Proceedings of the 1981 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571138-8.50016-0 · Cited by 770 · see citing works

Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer.

Linja, M. J., Savinainen, K., Saramäki, O. R., Tammela, T. L. J., Vessella, R. L., & Visakorpi, T. (2001) · PubMed · Cited by 762 · see citing works

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

Rommel, C., Clarke, B. A., Zimmermann, S., Nuñez, L., Rossman, R., Reid, K., Moelling, K., Yancopoulos, G. D., & Glass, D. J. (1999) · Science · doi:10.1126/science.286.5445.1738 · Cited by 759 · see citing works

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

Kousteni, S. (2001) · Cell · doi:10.1016/s0092-8674(02)08100-x · Cited by 749 · see citing works

A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein.

Lilja, H. G. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112185 · Cited by 746 · see citing works

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

Murakami, M., Hibi, M., Nakagawa, N., Nakagawa, T., Yasukawa, K., Yamanishi, K., Taga, T., & Kishimoto, T. (1993) · Science · doi:10.1126/science.8511589 · Cited by 724 · see citing works

Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.

Koivisto, P. A., Kononen, J., Palmberg, C., Tammela, T. L. J., HYYTINEN, E.-R., Isola, J. J., Trapman, J., Cleutjens, K. B. J. M., Noordzij, M. A., Visakorpi, T., et al. (1997) · PubMed · Cited by 717 · see citing works

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

Cairns, P., Okami, K., Halachmi, S., Halachmi, N., Esteller, M., Herman, J. G., Jen, J., Isaacs, W. B., Bova, G. S., & Sidransky, D. (1997) · PubMed · Cited by 707 · see citing works

PTEN: Life as a Tumor Suppressor

Simpson, L., & Parsons, R. E. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5130 · Cited by 679 · see citing works

Formation of the Androgen Receptor Transcription Complex

Shang, Y., Myers, M., & Brown, M. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00471-9 · Cited by 673 · see citing works

Steroid‐induced androgen receptor–oestradiol receptor β–Src complex triggers prostate cancer cell proliferation

Migliaccio, A., Castoria, G., Domenico, M. D., de Falco, A., Bilancio, A., Lombardi, M., Barone, M. V., Ametrano, D., Zannini, M. S., Abbondanza, C., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.20.5406 · Cited by 672 · see citing works

Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues

Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X., Lardy, H. A., Huang, K., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212474399 · Cited by 668 · see citing works

Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.

Lavinsky, R. M., Jepsen, K., Heinzel, T., Torchia, J., Mullen, T.-M., Schiff, R., Del-Rio, A. L., Ricote, M., Ngo, S., Gemsch, J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2920 · Cited by 660 · see citing works

STAT proteins: novel molecular targets for cancer drug discovery

Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1204086 · Cited by 643 · see citing works

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

McMenamin, M. E., Soung, P., Perera, S., Kaplan, I. D., Loda, M. F., & Sellers, W. R. (1999) · PubMed · Cited by 637 · see citing works

Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

Yeh, S., & Chang, C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5517 · Cited by 632 · see citing works

Transcriptional activation and nuclear targeting signals of the human androgen receptor.

Simental, J. A., Sar, M., Lane, M. V., French, F. S., & Wilson, E. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52466-2 · Cited by 631 · see citing works

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

Chung, J., Uchida, E., Grammer, T. C., & Blenis, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6508 · Cited by 620 · see citing works

A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.

Gregory, C. W., He, B., Johnson, R. T., Ford, O. H., Mohler, J. L., French, F. S., & Wilson, E. (2001) · PubMed · Cited by 603 · see citing works

Testosterone Formation and Metabolism During Male Sexual Differentiation in the Human Embryo

Siiteri, P. K., & Wilson, J. D. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-1-113 · Cited by 598 · see citing works

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

Yeh, S., Lin, H., Kang, H., Thin, T. H., Lin, M., & Chang, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5458 · Cited by 594 · see citing works

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.

Taplin, M., Bubley, G. J., Ko, Y., Small, E. J., Upton, M. P., Rajeshkumar, B. R., & Balk, S. P. (1999) · PubMed · Cited by 594 · see citing works

Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays.

Bubendorf, L., Kononen, J., Koivisto, P. A., Schraml, P., Moch, H., Gasser, T. C., Willi, N., Mihatsch, M. J., Sauter, G., & Kallioniemi, O. (1999) · PubMed · Cited by 592 · see citing works

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

Colombel, M. C., Symmans, W. F., de Medina, S. G. D., O’Toole, K., Chopin, D. K., Benson, M. C., Olsson, C. A., Korsmeyer, S. J., & Buttyan, R. (1993) · PubMed Central · Cited by 591 · see citing works

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

Krajewska, M., Krajewski, S., Epstein, J. I., Shabaik, A. S., Sauvageot, J., Song, K. B., Kitada, S., & Reed, J. C. (1996) · Europe PMC (PubMed Central) · Cited by 590 · see citing works

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

Grandis, J. R., Drenning, S. D., Zeng, Q., Watkins, S. C., Melhem, M. F., Endo, S., Johnson, D. E., Huang, L., He, Y., & Kim, J. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4227 · Cited by 588 · see citing works

Association of Prostate Cancer Risk With Genetic Polymorphisms in Vitamin D Receptor and Androgen Receptor

Ingles, S. A., Ross, R. K., Yu, M. C., Haile, R. W., Irvine, R. A., Pera, G. L., & Coetzee, G. A. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.2.166 · Cited by 582 · see citing works

Regulation of G 1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

Ramaswamy, S., Nakamura, N., Vázquez, F., Batt, D. B., Perera, S., Roberts, T. M., & Sellers, W. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2110 · Cited by 575 · see citing works

The Human Androgen Receptor: Complementary Deoxyribonucleic Acid Cloning, Sequence Analysis and Gene Expression in Prostate

Lubahn, D. B., JOSEPH, D. R., Sar, M., Tan, J.-A., Higgs, H. N., Larson, R. E., French, F. S., & Wilson, E. M. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-12-1265 · Cited by 570 · see citing works

The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions

Heinlein, C. A., & Chang, C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0070 · Cited by 568 · see citing works

Ras signalling and apoptosis

Downward, J. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80061-0 · Cited by 562 · see citing works

A candidate prostate cancer susceptibility gene at chromosome 17p

Tavtigian, S. V., Simard, J., Teng, D. H. ‐., Abtin, V., Baumgard, M. L., Beck, A., Camp, N. J., Carillo, A. R., Chen, Y., Dayananth, P., et al. (2001) · Nature Genetics · doi:10.1038/84808 · Cited by 557 · see citing works

X-linked Gene for Testicular Feminization in the Mouse

LYON, M. F., & HAWKES, S. G. (1970) · Nature · doi:10.1038/2271217a0 · Cited by 555 · see citing works

Androgen Receptor Signaling in Androgen-Refractory Prostate Cancer

Grossmann, M. E., Huang, H., & Tindall, D. J. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.22.1687 · Cited by 548 · see citing works

Steroid 5α-reductase 2 deficiency

Mendonca, B. B., Batista, R. L., Domenice, S., Costa, E. M. F., Arnhold, I. J. P., Russell, D. W., & Wilson, J. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.05.020 · Cited by 546 · see citing works

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo.

Raffo, A. J., Perlman, H., Chen, M., Day, M. L., Streitman, J., & Buttyan, R. (1995) · PubMed · Cited by 542 · see citing works

Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators.

Hoey, T., Weinzierl, R., Gill, G., Chen, J.-L., Dynlacht, B., & Tjian, R. (1993) · Cell · doi:10.1016/0092-8674(93)90664-c · Cited by 533 · see citing works

A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation.

Gill, G., Pascal, E., Tseng, Z. H., & Tjian, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.192 · Cited by 531 · see citing works

Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization

Jenster, G., van der Korput, H. A. G. M., van Vroonhoven, C., van der Kwast, T. H., Trapman, J., & Brinkmann, A. O. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-10-1396 · Cited by 523 · see citing works

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

Chang, C.-S., Kokontis, J. M., & Liao, S. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7211 · Cited by 519 · see citing works

Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1.

Tremblay, A., Tremblay, G., Labrie, F., & Giguère, V. (1999) · Molecules and Cells · doi:10.1016/s1097-2765(00)80479-7 · Cited by 514 · see citing works

Untitled work

(2001) · PubMed · Cited by 500 · see citing works

Integrin signalling and tyrosine phosphorylation: just the FAKs?

Schlaepfer, D. D., & Hunter, T. R. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01172-0 · Cited by 498 · see citing works

The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer.

Irvine, R. A., Yu, M. C., Ross, R. K., & Coetzee, G. A. (1995) · PubMed · Cited by 480 · see citing works

HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.

Wen, Y., Hu, M. C. ‐., Makino, K., Spohn, B., Bartholomeusz, G. A., Yan, D., & Hung, M. (2000) · PubMed · Cited by 461 · see citing works

RAFTK/Pyk2-mediated cellular signalling

Avraham, H. K., Park, S., Schinkmann, K. A., & Avraham, S. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(99)00076-5 · Cited by 459 · see citing works

Phosphorylation‐dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

Lin, H.-K., Wang, L., Hu, Y., Altuwaijri, S., & Chang, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf406 · Cited by 450 · see citing works

Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk.

Stanford, J. L., Just, J. J., Gibbs, M., Wicklund, K. G., Neal, C. L., Blumenstein, B. A., & Ostrander, E. A. (1997) · PubMed · Cited by 447 · see citing works

Evidence for a repressive function of the long polyglutamine tract in the human androgen receptor: possible pathogenetic relevance for the (CAG)n-expanded neuronopathies

Kazemi‐Esfarjani, P., Trifiro, M. A., & Pinsky, L. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.4.523 · Cited by 447 · see citing works

Androgen Receptor Localization in Different Cell Types of the Adult Rat Prostate*

Prins, G. S., Birch, L. A., & Greene, G. L. (1991) · Endocrinology · doi:10.1210/endo-129-6-3187 · Cited by 444 · see citing works

Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone

Čulig, Z., Hobisch, A., Cronauer, M. V., Cato, A. C. B., Hittmair, A., Radmayr, C., Eberle, J., Bartsch, G., & Klocker, H. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.12.8145761 · Cited by 440 · see citing works

The IGF-I receptor in cell growth, transformation and apoptosis

Baserga, R., Hongo, A., Rubini, M., di Prisco, M., & Valentinis, B. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00007-3 · Cited by 439 · see citing works

Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor.

Hobisch, A., Eder, I. E., Putz, T., Horninger, W., Bartsch, G. C., Klocker, H., & Čulig, Z. (1998) · PubMed · Cited by 437 · see citing works

AIB1 Is a Conduit for Kinase-Mediated Growth Factor Signaling to the Estrogen Receptor

de Mora, J. F., & Brown, M. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5041-5047.2000 · Cited by 432 · see citing works

Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.

Hara, T., Miyazaki, J., Araki, H., Yamaoka, M., Kanzaki, N., Kusaka, M., & Miyamoto, M. (2003) · PubMed · Cited by 425 · see citing works

The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1

Bevan, C. L., Hoare, S., Claessens, F., Heery, D. M., & Parker, M. G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8383 · Cited by 424 · see citing works

Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells

Xing, N. (2001) · Carcinogenesis · doi:10.1093/carcin/22.3.409 · Cited by 416 · see citing works

Androgen receptor gene mutations in human prostate cancer.

Newmark, J., Hardy, D. O., Tonb, D. C., Carter, B. S., Epstein, J. I., Isaacs, W. B., Brown, T. R., & Barrack, E. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6319 · Cited by 415 · see citing works

Expression of Transforming Growth Factor-β in the Rat Ventral Prostate during Castration-Induced Programmed Cell Death

Kyprianou, N., & Jt, I. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-10-1515 · Cited by 413 · see citing works

Regulation of Androgen Action

Roy, A. K., Lavrovsky, Y., Song, C., Chen, S., Jung, M. H., Velu, N., Bi, B., & Chatterjee, B. (1998) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60938-3 · Cited by 412 · see citing works

Two Androgen Response Regions Cooperate in Steroid Hormone Regulated Activity of the Prostate-specific Antigen Promoter

Cleutjens, K. B. J. M., Eekelen, C. C. E.-V., van der Korput, H. A. G. M., Brinkmann, A. O., & Trapman, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6379 · Cited by 408 · see citing works

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

Lin, H.-K., Yeh, S., Kang, H.-Y., & Chang, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121173298 · Cited by 401 · see citing works

Her-2-neu Expression and Progression Toward Androgen Independence in Human Prostate Cancer

Signoretti, S. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.23.1918 · Cited by 397 · see citing works

Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

Tilley, W. D., Buchanan, G., Hickey, T. E., & Bentel, J. M. (1996) · PubMed · Cited by 394 · see citing works

Androgen receptors in endocrine‐therapy‐resistant human prostate cancer

van der Kwast, T., Schalken, J. A., de Winter, J. A. R., van Vroonhoven, J. C. C., Mulder, E., Boersma, W. J. A., & Trapman, J. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910480206 · Cited by 387 · see citing works

ELEVATED LEVELS OF CIRCULATING INTERLEUKIN-6 AND TRANSFORMING GROWTH FACTOR-beta 1 IN PATIENTS WITH METASTATIC PROSTATIC CARCINOMA

Adler, H. L., McCURDY, M. A., Kattan, M. W., Timme, T. L., Scardino, P. T., & Thompson, T. C. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(01)62092-5 · Cited by 387 · see citing works

Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways.

Ueda, T., Bruchovsky, N., & Sadar, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108255200 · Cited by 381 · see citing works

Nongenomic Actions of Steroid Hormones in Reproductive Tissues*

Revelli, A., Massobrio, M., & Tesařík, J. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.1.0322 · Cited by 378 · see citing works

Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression

Graff, J. R., Konicek, B. W., McNulty, A. M., Wang, Z., Houck, K. A., Allen, S. E., Paul, J., Hbaiu, A., Goode, R. G., Sandusky, G. E., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003145200 · Cited by 378 · see citing works

Phosphorylation of the Nuclear Receptor SF-1 Modulates Cofactor Recruitment

Hammer, G. D., Krylova, I., Zhang, Y., Darimont, B. D., Simpson, K., Weigel, N. L., & Ingraham, H. A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80480-3 · Cited by 375 · see citing works

An Androgen Response Element in a Far Upstream Enhancer Region Is Essential for High, Androgen-Regulated Activity of the Prostate-Specific Antigen Promoter

Cleutjens, K. B. J. M., van der Korput, H. A. G. M., Eekelen, C. C. E.-V., van Rooij, H. C. J., Faber, P. W., & Trapman, J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.2.9883 · Cited by 375 · see citing works

Dehydroepiandrosterone Activates Mutant Androgen Receptors Expressed in the Androgen-Dependent Human Prostate Cancer Xenograft CWR22 and LNCaP Cells

Tan, J.-A., Sharief, Y., Hamil, K. G., Gregory, C. W., Zang, D.-Y., Sar, M., Gumerlock, P. H., White, R. D., Pretlow, T. G., Harris, S. E., et al. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9906 · Cited by 375 · see citing works

Activation Function 2 in the Human Androgen Receptor Ligand Binding Domain Mediates Interdomain Communication with the NH2-terminal Domain

He, B., Kemppainen, J., Voegel, J. J., Gronemeyer, H., & Wilson, E. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37219 · Cited by 372 · see citing works

Beta-catenin mutations in human prostate cancer.

Voeller, H. J., Truica, C., & Gelmann, E. P. (1998) · PubMed · Cited by 365 · see citing works

Androgen Receptor Mutations in Androgen-Independent Prostate Cancer: Cancer and Leukemia Group B Study 9663

Taplin, M., Rajeshkumar, B. R., Halabi, S., Werner, C. P., Woda, B. A., Picus, J., Stadler, W. M., Hayes, D. F., Kantoff, P. W., Vogelzang, N. J., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.11.102 · Cited by 364 · see citing works

Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers.

Gaddipati, J. P., McLeod, D. G. R., Heidenberg, H. B., Sesterhenn, I. A., Finger, M. J., Moul, J. W., & Srivastava, S. (1994) · PubMed · Cited by 363 · see citing works

Antagonistic effect of androgen on prostatic cell death

Isaacs, J. T. (1984) · The Prostate · doi:10.1002/pros.2990050510 · Cited by 349 · see citing works

Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.

Truica, C. I., Byers, S. W., & Gelmann, E. P. (2000) · PubMed · Cited by 349 · see citing works

Implication of cell kinetic changes during the progression of human prostatic cancer.

Berges, R. R., Vukanovic, J., Epstein, J. I., CarMichel, M., Cisek, L. J., Johnson, D. E., Veltri, R. W., Walsh, P. C., & Isaacs, J. T. (1995) · PubMed · Cited by 342 · see citing works

Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer.

de Winter, J. A. R., Janssen, P. J. A., Sleddens, H. M., Verleun-Mooijman, M. C. T., Trapman, J., Brinkmann, A. O., Santerse, A. B., Schröder, F. H., & van der Kwast, T. (1994) · PubMed Central · Cited by 333 · see citing works

Cellular functions of plasma membrane estrogen receptors

Levin, E. R. (2002) · Steroids · doi:10.1016/s0039-128x(01)00179-9 · Cited by 328 · see citing works

Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.

Ueda, T., Mawji, N. R., Bruchovsky, N., & Sadar, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203313200 · Cited by 311 · see citing works

Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China.

Hsing, A. W., Gao, Y., Wu, G., Wang, X., Deng, J., Chen, Y., Sesterhenn, I. A., Mostofi, F. K., Bénichou, J., & Chang, C. (2000) · PubMed · Cited by 311 · see citing works

Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro.

Okamoto, M., Lee, C., & Oyasu, R. (1997) · PubMed · Cited by 307 · see citing works

The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild‐type and androgen‐insensitive (Tfm) Mice

Cunha, G. R., & Lung, B. (1978) · Journal of Experimental Zoology · doi:10.1002/jez.1402050203 · Cited by 303 · see citing works

Genetic Alterations in Hormone-Refractory Recurrent Prostate Carcinomas

Nupponen, N. N., Kakkola, L., Koivisto, P., & Visakorpi, T. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65554-x · Cited by 303 · see citing works

Androgen receptor mutations in prostate cancer.

Barrack, E. R. (1996) · PubMed · Cited by 301 · see citing works

Cloning and Characterization of Androgen Receptor Coactivator, ARA55, in Human Prostate

Fujimoto, N., Yeh, S., Kang, H., Inui, S., Chang, H., Mizokami, A., & Chang, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8316 · Cited by 294 · see citing works

Interleukin-6: A candidate mediator of human prostate cancer morbidity

Twillie, D. A., Eisenberger, M. A., Carducci, M. A., Hseih, W.-S., Kim, W. Y., & Simons, J. W. (1995) · Urology · doi:10.1016/s0090-4295(99)80034-x · Cited by 286 · see citing works

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice

DiGiovanni, J., Kiguchi, K., Frijhoff, A. F. W., Wilker, E., Bol, D. K., Beltrán, L., Moats, S., Ramı́rez, Á., Jorcano, J. L., & Conti, C. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3455 · Cited by 281 · see citing works

Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

Qiu, Y., Ravi, L., & Kung, H.-J. (1998) · Nature · doi:10.1038/30012 · Cited by 280 · see citing works

Interleukin-6 Protects against Fas-mediated Death by Establishing a Critical Level of Anti-apoptotic Hepatic Proteins FLIP, Bcl-2, and Bcl-xL

Kovalovich, K. K., Li, W., DeAngelis, R. A., Greenbaum, L. E., Ciliberto, G., & Taub, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100740200 · Cited by 277 · see citing works

Molecular Cloning and Functional Analysis of Sialyltransferases

Tsuji, S. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021369 · Cited by 277 · see citing works

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

Davies, M. A., Koul, D., Dhesi, H., et al. (1999) · PubMed · Cited by 276 · see citing works

Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration

English, H. F., Kyprianou, N., & Isaacs, J. T. (1989) · The Prostate · doi:10.1002/pros.2990150304 · Cited by 274 · see citing works

Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes.

Gregory, C. W., Hamil, K. G., Kim, D., Hall, S. H., Pretlow, T. G., Mohler, J. L., & French, F. S. (1998) · PubMed · Cited by 273 · see citing works

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

Cohen, P., Peehl, D. M., Graves, H. C. B., et al. (1994) · Journal of Endocrinology · doi:10.1677/joe.0.1420407 · Cited by 270 · see citing works

PDEF, a Novel Prostate Epithelium-specific Ets Transcription Factor, Interacts with the Androgen Receptor and Activates Prostate-specific Antigen Gene Expression

Oettgen, P., Finger, E., Sun, Z., Akbarali, Y., Thamrongsak, U., Boltax, J., Grall, F., Dube, A., Weiss, A., Brown, L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1216 · Cited by 268 · cited 5× · see citing works

From estrogen to androgen receptor: A new pathway for sex hormones in prostate

Yeh, S., Miyamoto, H., Shima, H., & Chang, C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5527 · Cited by 267 · see citing works

Phosphorylation of Steroid Receptor Coactivator-1

Rowan, B. G., Weigel, N. L., & O’Malley, B. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4475 · Cited by 267 · see citing works

Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity: specificity in prostate and non-prostate cell lines

Beilin, J., Ball, E., Favaloro, J., & Zajac, J. D. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250085 · Cited by 265 · see citing works

Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length

Irvine, R. A. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.2.267 · Cited by 263 · see citing works

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

Myers, M. G., Grammer, T. C., Wang, L. M., Sun, X., Pierce, J. H., Blenis, J., & White, M. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61974-5 · Cited by 261 · see citing works

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.

Qiu, Y., Robinson, D., Pretlow, T., & Kung, H. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.7.3644 · Cited by 258 · see citing works

Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.

Chen, T., Wang, L. H., & Farrar, W. L. (2000) · PubMed · Cited by 258 · see citing works

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

Turkson, J., Bowman, T. L., Adnane, J., Zhang, Y., Djeu, J. Y., Sekharam, M., Frank, D. A., Holzman, L. B., Wu, J., Sebti, S. M., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7519 · Cited by 256 · see citing works

Characterization of the role of IL‐6 in the progression of prostate cancer

Chung, T., Yu, J.-Q., Spiotto, M., Bartkowski, M., & Simons, J. (1999) · The Prostate · doi:10.1002/(sici)1097-0045(19990215)38:3 · Cited by 253 · see citing works

Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset

Hardy, D. O., Scher, H. I., Bogenreider, T., Sabbatini, P. J., Zhang, Z., Nanus, D. M., & Catterall, J. F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954049 · Cited by 248 · see citing works

8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein

Rowan, B. G., Garrison, N., Weigel, N. L., & O’Malley, B. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8720-8730.2000 · Cited by 244 · see citing works

Testosterone Stimulates Angiogenesis and Vascular Regrowth in the Ventral Prostate in Castrated Adult Rats

Lissbrant, I. F., Rudolfsson, S. H., Damber, J., & Bergh, A. (1998) · Endocrinology · doi:10.1210/endo.139.2.5683 · Cited by 243 · see citing works

Androgen Receptor Expression in Developing Male Reproductive Organs*

Cooke, P. S., Young, P., & Cunha, G. R. (1991) · Endocrinology · doi:10.1210/endo-128-6-2867 · Cited by 241 · see citing works

STEM CELL FEATURES OF BENIGN AND MALIGNANT PROSTATE EPITHELIAL CELLS

Marzo, A. M. D., Nelson, W. G., Meeker, A. K., & Coffey, D. S. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62196-7 · Cited by 239 · see citing works

Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors.Preprint

Nakajima, T., Uchida, C., Anderson, S. F., Parvin, J. D., & Montminy, M. (1997) · Genes & Development · doi:10.1101/gad.11.6.738 · Cited by 238 · see citing works

High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130.

Ward, L. D., Howlett, G. J., Discolo, G., Yasukawa, K., Hammacher, A., Moritz, R. L., & Simpson, R. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31651-4 · Cited by 237 · see citing works

IL-6-regulated transcription factors

Akira, S. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00063-0 · Cited by 231 · see citing works

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

Cutler, R. L., Liu, L., Damen, J. E., & Krystal, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80558-4 · Cited by 228 · see citing works

Androgen receptor gene mutations in human prostate cancer

Suzuki, H., Sato, N., Watabe, Y., Masai, M., Seino, S., & Shimazaki, J. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90316-o · Cited by 226 · see citing works

Functional characterization of mutant androgen receptors from androgen-independent prostate cancer.

Fenton, M. A., Shuster, T. D., Fertig, A., Taplin, M. E., Kolvenbag, G. J. C. M., Bubley, G. J., & Balk, S. P. (1997) · PubMed · Cited by 225 · see citing works

Negative controls of cell proliferation: human prostate cancer cells and androgens.

Sonnenschein, C., Olea, N., Pasanen, M. E., & Soto, A. M. (1989) · PubMed · Cited by 224 · see citing works

Growth factor involvement in progression of prostate cancer

Russell, P. J., Bennett, S., & Stricker, P. D. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.4.705 · Cited by 223 · see citing works

The Linkage of Kennedy's Neuron Disease to ARA24, the First Identified Androgen Receptor Polyglutamine Region-associated Coactivator

Hsiao, P., Lin, D., Nakao, R., & Chang, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20229 · Cited by 221 · see citing works

p300 in prostate cancer proliferation and progression.

Debes, J. D., Sebo, T. J., Lohse, C. M., Murphy, L. M., Haugen, D. A. L., & Tindall, D. J. (2003) · PubMed · Cited by 219 · see citing works

Effect of Transforming Growth Factor-β1on Proliferation and Death of Rat Prostatic Cells*

MARTIKAINEN, P. M., Kyprianou, N., & Isaacs, J. T. (1990) · Endocrinology · doi:10.1210/endo-127-6-2963 · Cited by 217 · see citing works

Hormones and Prostate Cancer: What's Next?

Hsing, A. W. (2001) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a000795 · Cited by 216 · see citing works

Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development

Halkidou, K., Gnanapragasam, V. J., Mehta, P. B., Logan, I. R., Brady, M. E., Cook, S., Leung, H. Y., Neal, D. E., & Robson, C. N. (2003) · Oncogene · doi:10.1038/sj.onc.1206342 · Cited by 214 · see citing works

Akt/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation

Okano, J., Gaslightwala, I., Birnbaum, M. J., Rustgi, A. K., & Nakagawa, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004112200 · Cited by 214 · see citing works

Prostate-specific antigen

Stenman, U., Leinonen, J., Zhang, W., & Finne, P. (1999) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0086 · Cited by 213 · see citing works

Breast and Prostate Cancer: An Analysis of Common Epidemiological, Genetic, and Biochemical Features

López-Otı́n, C., & Diamandis, E. P. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.4.0337 · Cited by 212 · see citing works

Functional Interactions of the AF-2 Activation Domain Core Region of the Human Androgen Receptor with the Amino-Terminal Domain and with the Transcriptional Coactivator TIF2 (Transcriptional Intermediary Factor 2)

Berrevoets, C., Doesburg, P., Steketee, K., Trapman, J., & Brinkmann, A. O. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.8.0153 · Cited by 212 · see citing works

Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence.

Shibanuma, M., Mashimo, J., Kuroki, T., & Nose, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47085-8 · Cited by 209 · see citing works

Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT*

Liao, G., Chen, L.-Y., Zhang, A., Godavarthy, A., Xia, F., Ghosh, J. C., Li, H., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206374200 · Cited by 207 · see citing works

Aberrant response in vitro of hormone‐responsive prostate cancer cells to antiandrogens

Wilding, G., Chen, M. J., & Gelmann, E. P. (1989) · The Prostate · doi:10.1002/pros.2990140204 · Cited by 205 · see citing works

Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells

Miyamoto, H., Yeh, S., Wilding, G., & Chang, C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7379 · Cited by 203 · see citing works

Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells.

Bakin, R. E., Gioeli, D. G., Sikes, R. A., Bissonette, E. A., & Weber, M. J. (2003) · PubMed · Cited by 201 · see citing works

Methylation and Inactivation of Estrogen, Progesterone, and Androgen Receptors in Prostate Cancer

Sasaki, M. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.5.384 · Cited by 200 · see citing works

Assessment of prostatic protein secretion in tissue recombinants made of urogenital sinus mesenchyme and urothelium from normal or androgen- insensitive mice

Donjacour, A. A., & Cunha, G. R. (1993) · Endocrinology · doi:10.1210/endo.132.6.7684975 · Cited by 199 · see citing works

Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride.

Umekita, Y., Hiipakka, R. A., Kokontis, J. M., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11802 · Cited by 195 · see citing works

Prostate Specific Antigen Cleaves Parathyroid Hormone-Related Protein in the PTH-like Domain: Inactivation of PTHrP-Stimulated cAMP Accumulation in Mouse Osteoblasts

Cramer, S. D., Chen, Z., & Peehl, D. M. (1996) · The Journal of Urology · doi:10.1016/s0022-5347(01)65919-6 · Cited by 194 · see citing works

SMAD3 represses androgen receptor-mediated transcription.

Hayes, S. A., Zarnegar, M. A., Sharma, M., Yang, F., Peehl, D. M., ten Dijke, P., & Sun, Z. (2001) · PubMed · Cited by 192 · see citing works

Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels.

Singh, R. P., Dhanalakshmi, S., Tyagi, A. K., et al. (2002) · PubMed · Cited by 192 · see citing works

STAT3 mediates IL‐6‐induced neuroendocrine differentiation in prostate cancer cells

Spiotto, M., & Chung, T. (2000) · The Prostate · doi:10.1002/(sici)1097-0045(20000215)42:3 · Cited by 191 · see citing works

Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer.

Hakimi, J. M., Schoenberg, M., Rondinelli, R. H., et al. (1997) · PubMed · Cited by 190 · see citing works

Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer

Gnanapragasam, V. J., Leung, H. Y., Pulimood, A., Neal, D. E., & Robson, C. N. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2179 · Cited by 189 · see citing works

The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen.

Prins, G. S., & Birch, L. A. (1995) · Endocrinology · doi:10.1210/endo.136.3.7867585 · Cited by 188 · see citing works

Identification of Genetic Markers for Prostatic Cancer Progression

Alers, J. C., Rochat, J., Krijtenburg, P.-J., Hop, W. C. J., Ries Kranse, C., Rosenberg, C., Tanke, H. J., Schröder, F. H., & van Dekken, H. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780096 · Cited by 187 · see citing works

Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation

Ikonen, T., Palvimo, J. J., Kallio, P. J., Reinikainen, P., & Jänne, O. A. (1994) · Endocrinology · doi:10.1210/endo.135.4.7925097 · Cited by 187 · see citing works

Suppression Versus Induction of Androgen Receptor Functions by the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer LNCaP Cells with Different Passage Numbers

Lin, H., Hu, Y., Yang, L., Altuwaijri, S., Chen, Y.-T., Kang, H., & Chang, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300676200 · Cited by 187 · see citing works

Short Communication

Gerdes, D., Wehling, M., Leube, B., & Falkenstein, E. (1998) · Biological Chemistry · doi:10.1515/bchm.1998.379.7.907 · Cited by 186 · see citing works

Molecular and cellular biology of interleukin-6 and its receptor

Keller, E. T. (1996) · Frontiers in bioscience · doi:10.2741/a136 · Cited by 185 · see citing works

Expression and Degradation of Androgen Receptor: Mechanism and Clinical Implication

Lee, D., & Chang, C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030261 · Cited by 184 · see citing works

Intermittent androgen suppression delays progression to androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumour model

Sato, N., Gleave, M. E., Bruchovsky, N., Rennie, P. S., Goldenberg, S. L., Lange, P. H., & Sullivan, L. D. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(96)00018-0 · Cited by 183 · see citing works

Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells

(2003) · doi:10.1074/jbc.m300588200 · Cited by 183 · see citing works

Basic fibroblast growth factor in human prostate cancer cells.

Nakamoto, T., Chang, C., Li, A. K., et al. (1992) · PubMed · Cited by 183 · see citing works

Role of p53 family members in apoptosis

Sheikh, M. S., & Fornace, A. J. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200002)182:2 · Cited by 182 · see citing works

Collocation of androgen receptor gene mutations in prostate cancer.

Buchanan, G., Greenberg, N. M., Scher, H. I., Harris, J. M., Marshall, V. R., & Tilley, W. D. (2001) · PubMed · Cited by 181 · see citing works

Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4

Goddard, K. A. B., Witte, J. S., Suarez, B. K., Catàlona, W. J., & Olson, J. M. (2001) · The American Journal of Human Genetics · doi:10.1086/320103 · Cited by 178 · see citing works

Allelic imbalance and microsatellite instability in prostatic adenocarcinoma.

Cunningham, J. M., Shan, A., Wick, M. J., et al. (1996) · PubMed · Cited by 173 · see citing works

Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase Structurally Related to Focal Adhesion Kinase

Xiong, W., & Parsons, J. T. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.2.529 · Cited by 173 · see citing works

Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer.

Hu, R., Dunn, T. A., Wei, S., Isharwal, S., Veltri, R. W., Humphreys, E., Han, M., Partin, A. W., Vessella, R. L., Isaacs, W. B., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2764 · Cited by 1,077 · see citing works

A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

Guo, Z., Yang, X., Sun, F., Jiang, R., Linn, D. E., Chen, H., Chen, H., Kong, X., Melamed, J., Tepper, C. G., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3795 · Cited by 880 · see citing works

Splicing of a Novel <i>Androgen Receptor</i> Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

Dehm, S. M., Schmidt, L. J., Heemers, H. V., Vessella, R. L., & Tindall, D. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0594 · Cited by 834 · see citing works

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

Lin, C., Yang, L., Tanasa, B., Hutt, K., Ju, B.-G., Ohgi, K. A., Zhang, J., Rose, D. W., Fu, X.-D., Glass, C. K., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.030 · Cited by 576 · see citing works

Interaction of Nuclear Receptors with the Wnt/β-Catenin/Tcf Signaling Axis: Wnt You Like to Know?

Mulholland, D. J., Dedhar, S., Coetzee, G. A., & Nelson, C. C. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0034 · Cited by 377 · see citing works

Regulation of androgen receptor activity by tyrosine phosphorylation.

Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V. D., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.021 · Cited by 364 · see citing works

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

Salami, J., Alabi, S., Willard, R. R., Vitale, N. J., Wang, J., Dong, H., Jin, M., McDonnell, D. P., Crew, A. P., Neklesa, T. K., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0105-8 · Cited by 349 · see citing works

Molecular regulation of androgen action in prostate cancer.

Dehm, S. M., & Tindall, D. J. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20794 · Cited by 336 · see citing works

A surface on the androgen receptor that allosterically regulates coactivator binding

Estébanez-Perpiñá, E., Arnold, L. A., Nguyen, P., Rodrigues, E. D., Mar, E., Bateman, R., Pallai, P., Shokat, K. M., Baxter, J. D., Guy, R. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708036104 · Cited by 307 · see citing works

Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.

Zhu, M.-L., & Kyprianou, N. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0084 · Cited by 286 · see citing works

Comparison of Crystal Structures of Human Androgen Receptor Ligand-Binding Domain Complexed with Various Agonists Reveals Molecular Determinants Responsible for Binding Affinity

Pereira de Jésus‐Tran, K., Côté, P., Cantin, L., Blanchet, J., Labrie, F., & Breton, R. (2006) · Protein Science · doi:10.1110/ps.051905906 · Cited by 278 · see citing works

Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

Gustafson, J. L., Neklesa, T. K., Cox, C. S., Roth, A. G., Buckley, D. L., Tae, H. S., Sundberg, T. B., Stagg, D. B., Hines, J., McDonnell, D. P., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201503720 · Cited by 206 · see citing works

The nuclear factor-κB pathway controls the progression of prostate cancer to androgen-independent growth.

Jin, R. J., Lho, Y., Connelly, L., Wang, Y., Yu, X., Saint Jean, L., Case, T. C., Ellwood-Yen, K., Sawyers, C. L., Bhowmick, N. A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0107 · Cited by 182 · see citing works

Roles and regulation of Wnt signaling and β-catenin in prostate cancer

Verras, M., & Sun, Z. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.06.004 · Cited by 180 · see citing works

Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer.

Gao, H., Ouyang, X., Banach-Petrosky, W. A., Gerald, W. L., Shen, M. M., & Abate-Shen, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606836103 · Cited by 141 · see citing works

Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells

Yang, L., Xie, S., Jamaluddin, M. S., Altuwaijri, S., Ni, J., Kim, E., Chen, Y.-T., Hu, Y.-C., Wang, L., Chuang, K.-H., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504461200 · Cited by 131 · see citing works

Interplay between two hormone-independent activation domains in the androgen receptor.

Callewaert, L., Van Tilborgh, N., & Claessens, F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2389 · Cited by 111 · see citing works

FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A

Periyasamy, S., Hinds, T., Shemshedini, L., Shou, W., & Sanchez, E. R. (2010) · Oncogene · doi:10.1038/onc.2009.458 · Cited by 108 · see citing works

Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers

Makkonen, H., Kauhanen, M., Paakinaho, V., Jääskeläinen, T., & Palvimo, J. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp352 · Cited by 97 · see citing works

Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling

Chouinard, S., Yueh, M.-F., Tukey, R. H., Giton, F., Fiet, J., Pelletier, G., Barbier, O., & Bélanger, A. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.016 · Cited by 90 · see citing works

Selective role of an NH2-terminal WxxLF motif for aberrant androgen receptor activation in androgen depletion-independent prostate cancer cells.

Dehm, S. M., Regan, K. M., Schmidt, L. J., & Tindall, D. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1267 · Cited by 84 · see citing works

Rational optimization of a transcription factor activation domain inhibitor

Basu, S., Martínez-Cristóbal, P., Frigolé-Vivas, M., Pesarrodona, M., Lewis, M., Szulc, E., Bañuelos, C. A., Sánchez-Zarzalejo, C., Bielskutė, S., Zhu, J., et al. (2023) · Nature Structural &amp; Molecular Biology · doi:10.1038/s41594-023-01159-5 · Cited by 83 · see citing works

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

Eftekharzadeh, B., Banduseela, V. C., Chiesa, G., Martínez-Cristóbal, P., Rauch, J. N., Nath, S. R., Schwarz, D. M. C., Shao, H., Marin-Argany, M., Di Sanza, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11594-y · Cited by 76 · see citing works

Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer.

Lyons, L. S., Rao, S., Balkan, W., Faysal, J., Maiorino, C. A., & Burnstein, K. L. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0158 · Cited by 67 · see citing works

Overexpression of aldo–keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

Byrns, M. C., Mindnich, R., Duan, L., & Penning, T. M. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.12.012 · Cited by 60 · see citing works

DNA‐Binding Small Molecules as Inhibitors of Transcription Factors

Leung, C., Chan, D. S., Ma, V. P., & Ma, D. (2013) · Medicinal Research Reviews · doi:10.1002/med.21266 · Cited by 58 · see citing works

Multi-omics Biomarker Pipeline Reveals Elevated Levels of Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of Prostate Cancer Patients

Drabovich, A. P., Saraon, P., Drabovich, M., Karakosta, T. D., Dimitromanolakis, A., Hyndman, M. E., Jarvi, K., & Diamandis, E. P. (2019) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.ra119.001612 · Cited by 40 · see citing works

Transcription factors and cognate signalling cascades in the regulation of autophagy

Chandra, V., Bhagyaraj, E., Parkesh, R., & Gupta, P. (2016) · Biological Reviews · doi:10.1111/brv.12177 · Cited by 26 · see citing works

Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

Li, H., Melnyk, J. E., Fu, B. X. H., Shrestha, R., Zhang, M., Sjöström, M., Feng, S., Anderson, J. A., Han, W., Chesner, L. N., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02388-8 · Cited by 10 · see citing works

Developments in Nonsteroidal Antiandrogens Targeting the Androgen Receptor

Liu, B., Su, L., Geng, J., Liu, J., & Zhao, G. (2010) · ChemMedChem · doi:10.1002/cmdc.201000259 · Cited by 21 · see citing works

Advances in Androgen Receptor Targeted Therapy for Prostate Cancer

Ahmed, A., Ali, S. S., & Sarkar, F. H. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24456 · Cited by 60 · see citing works

Homologous Androgen Receptor Up-Regulation in Osteoblastic Cells May Be Associated with Enhanced Functional Androgen Responsiveness

Wiren, K. M., Keenan, E. J., Zhang, X., Ramsey, B., & ORWOLL, E. S. (1999) · Endocrinology · doi:10.1210/endo.140.7.6753 · Cited by 34 · see citing works

Androgen receptor in prostate cancer: cause or cure?

Bevan, C. L. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.09.006 · Cited by 9 · see citing works

Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

Sundén, H., Holland, M. C., Poutiainen, P., Jääskeläinen, T. J., Pulkkinen, J. T., Palvimo, J. J., & Olsson, R. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501995n · Cited by 20 · see citing works