The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
β1- and α6-integrin are surface markers on mouse spermatogonial stem cells
Open accessAbstract
Although spermatogenesis is essential for reproduction, little is known about spermatogonial stem cells. These cells provide the basis for spermatogenesis throughout adult life by undergoing self-renewal and by providing progeny that differentiate into spermatozoa. A major impediment to our understanding of the biology of these stem cells is the inability to distinguish them from spermatogonia that are committed to differentiation. We made use of the known association of stem cells with basement membranes and our spermatogonial transplantation assay system to identify specific molecular markers on the stem cell surface. Selection of mouse testis cells with anti-β 1- or anti-α 6-integrin antibody, but not anti-c-kit antibody, produced cell populations with a significantly enhanced ability to colonize recipient testes and generate donor cell-derived spermatogenesis. We demonstrate spermatogonial stem cell-associated antigens by using an assay system based on biological function. Furthermore, the presence of surface integrins on spermatogonial stem cells suggests that these cells share elements of a common molecular machinery with stem cells in other tissues.
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Cites
Essential role of mouse telomerase in highly proliferative organs
Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270
Cited by
Long-Term Proliferation in Culture and Germline Transmission of Mouse Male Germline Stem Cells1
Kanatsu-Shinohara, M., Ogonuki, N., Inoue, K., Miki, H., Ogura, A., Toyokuni, S., & Shinohara, T. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.017012 · Cited by 1,048
Self-citationThe Germline Stem Cell Niche Unit in Mammalian Testes
Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 513
Self-citationKubota, H., Avarbock, M. R., & Brinster, R. L. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.029207 · Cited by 344
Self-citationCD9 Is a Surface Marker on Mouse and Rat Male Germline Stem Cells1
Kanatsu-Shinohara, M., Toyokuni, S., & Shinohara, T. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.020867 · Cited by 286
Self-citationWang, X., Ding, Q., Zhang, Y., Wang, H., Ma, L., & Xie, X. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.049 · Cited by 10
Metadata
- Authors
- Shinohara, T., Avarbock, M. R., & Brinster, R. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-05-11
- Volume
- 96
- Issue
- 10
- Pages
- 5504-5509
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2067924039
- Cited by
- 575
- References
- 1
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: β1- and α6-integrin are surface markers on mouse spermatogonial stem cells. https://app.cochat.ai/papers/10.1073/pnas.96.10.5504
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- Shinohara, T., Avarbock, M. R., & Brinster, R. L. (1999). β1- and α6-integrin are surface markers on mouse spermatogonial stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.10.5504
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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