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Molecular genetics of ecological diversification: Duplication and rapid evolution of toxin genes of the venomous gastropod Conus
Open accessAbstract
Predatory snails in the marine gastropod genus Conus stun prey by injecting a complex mixture of peptide neurotoxins. These conotoxins are associated with trophic diversification and block a diverse array of ion channels and neuronal receptors in prey species, but the evolutionary genesis of this functional diversity is unknown. Here we show that conotoxins with little amino acid similarity are in fact products of recently diverged loci that are rapidly evolving by strong positive selection in the vermivorous cone, Conus abbreviatus , and that the rate of conotoxin evolution is higher than that of most other known proteins. Gene duplication and diversifying selection result in the formation of functionally variable conotoxins that are linked to ecological diversification and evolutionary success of this genus.
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Citations
Cited by
Evolution by gene duplication: An update
Zhang, J. (2003) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(03)00033-8 · Cited by 2,201
Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins
Akondi, K. B., Muttenthaler, M., Dutertre, S., Kaas, Q., Craik, D. J., Lewis, R. J., & Alewood, P. F. (2014) · Chemical Reviews · doi:10.1021/cr400401e · Cited by 323
Positive selection of a gene family during the emergence of humans and African apes
Johnson, M. E., Viggiano, L., Bailey, J. A., Abdul-Rauf, M., Goodwin, G., Rocchi, M., & Eichler, E. E. (2001) · Nature · doi:10.1038/35097067 · Cited by 296
What Is the Role of Genome Duplication in the Evolution of Complexity and Diversity?
Crow, K. D. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msj083 · Cited by 277
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians
Donia, M. S., Hathaway, B. J., Sudek, S., Haygood, M. G., Rosovitz, M. J., Ravel, J., & Schmidt, E. W. (2006) · Nature Chemical Biology · doi:10.1038/nchembio829 · Cited by 261
Metadata
- Authors
- Duda, T. F., & Palumbi, S. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-06-08
- Volume
- 96
- Issue
- 12
- Pages
- 6820-6823
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971968167
- Cited by
- 328
- References
- 0
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Duda, T. F., & Palumbi, S. R. (1999). Molecular genetics of ecological diversification: Duplication and rapid evolution of toxin genes of the venomous gastropod Conus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.12.6820
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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