The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
Open accessAbstract
Osteopontin is one of the major noncollagenous bone matrix proteins produced by osteoblasts and osteoclasts, bone cells that are uniquely responsible for the remodeling of mineralized tissues. Osteoclasts express the αvβ3 integrin, which is one of the receptors for osteopontin. Recent knockout studies revealed that noncollagenous bone matrix proteins are functionally important in regulation of bone metabolism. However, the significance of the presence of osteopontin in in vivo has not been known. We report here that osteopontin knockout mice are resistant to ovariectomy-induced bone resorption compared with wild-type mice. Microcomputed tomography analysis indicated about 60% reduction in bone volume by ovariectomy in wild-type mice, whereas the osteopontin-deficient mice exhibited only about 10% reduction in trabecular bone volume after ovariectomy. Reduction in uterine weight was observed similarly in both wild-type and osteopontin-deficient mice, indicating the specificity of the effect of osteopontin deficiency on bone metabolism. We propose that osteopontin is essential for postmenopausal osteoporosis in women. Strategies to counteract osteopontin’s action may prove effective in suppressing osteoporosis.
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Ross, F. P., Chappel, J., Alvarez, J. I., Sander, D., Butler, W. T., Farach-Carson, M. C., Mintz, K. A., Robey, P. G., Teitelbaum, S. L., & Cheresh, D. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98430-9 · Cited by 537
The Functional Block of TNF but Not of IL-6 Prevents Bone Loss in Ovariectomized Mice
Kimble, R. B., Bain, S., & Pacifici, R. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.6.935 · Cited by 241
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Bornstein, P., & Sage, E. H. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00361-7 · Cited by 965
Osteopontin: role in immune regulation and stress responses
Wang, K. X., & Denhardt, D. T. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.001 · Cited by 669
Self-citationThe multiple functions and mechanisms of osteopontin
Icer, M. A., & Gezmen-Karadag, M. (2018) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.07.003 · Cited by 606
Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E. B., Jones, K. L., Kawamori, R., Cassis, L. A., Tschöp, M. H., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31986 · Cited by 401
Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression
Potier, E., Ferreira, E., Andriamanalijaona, R., Pujol, J.-P., Oudina, K., Logeart-Avramoglou, D., & Petite, H. (2007) · Bone · doi:10.1016/j.bone.2006.11.024 · Cited by 294
Metadata
- Authors
- Yoshitake, H., Rittling, S. R., Denhardt, D. T., & Noda, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-07-06
- Volume
- 96
- Issue
- 14
- Pages
- 8156-8160
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043033796
- Cited by
- 374
- References
- 2
- FWCI
- 10.96
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. https://app.cochat.ai/papers/10.1073/pnas.96.14.8156
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- Yoshitake, H., Rittling, S. R., Denhardt, D. T., & Noda, M. (1999). Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.14.8156
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