The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum
Open accessAbstract
Many pathogens evade the host immune response or adapt to their environment by expressing surface proteins that undergo rapid switching. In the case of Plasmodium falciparum , products of a multigene family known as var are expressed on the surface of infected red cells, where they undergo clonal antigenic variation and contribute to malaria pathogenesis by mediating adhesion to a variety of host endothelial receptors and to uninfected red blood cells by forming rosettes. Herein we show that a second gene family, rif , which is associated with var at subtelomeric sites in the genome, encodes clonally variant proteins (rifins) that are expressed on the infected red cell surface. Their high copy number, sequence variability, and red cell surface location indicate an important role for rifins in malaria host–parasite interaction.
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Self-citationRapid switching to multiple antigenic and adhesive phenotypes in malaria
Roberts, D. J., Craig, Berendt, A. R., Pinches, R., Nash, G., Marsh, K., & Newbold, C. I. (1992) · Nature · doi:10.1038/357689a0 · Cited by 619
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Cited by
Genome sequence of the human malaria parasite Plasmodium falciparum
Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R. W., Carlton, J. M., Pain, A., Nelson, K. E., Bowman, S., et al. (2002) · Nature · doi:10.1038/nature01097 · Cited by 4,407
Self-citationA proteomic view of the Plasmodium falciparum life cycle
Florens, L., Washburn, M. P., Raine, J. D., Anthony, R. M., Grainger, M., Haynes, J. D., Moch, J. K., Muster, N., Sacci, J. B., Tabb, D. L., et al. (2002) · Nature · doi:10.1038/nature01107 · Cited by 1,308
Doolan, D. L., Dobaño, C., & Baird, J. K. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00025-08 · Cited by 1,301
Ward, P., Equinet, L., Packer, J., & Doerig, C. (2004) · BMC Genomics · doi:10.1186/1471-2164-5-79 · Cited by 507
Antigenic Variation in Plasmodium falciparum
Scherf, A., Lopez-Rubio, J. J., & Riviere, L. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093134 · Cited by 447
Metadata
- Authors
- Kyes, S. A., Rowe, J. A., Kriek, N., & Newbold, C. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-08-03
- Volume
- 96
- Issue
- 16
- Pages
- 9333-9338
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2103900678
- Cited by
- 325
- References
- 4
- FWCI
- 20.54
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum. https://app.cochat.ai/papers/10.1073/pnas.96.16.9333
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- Kyes, S. A., Rowe, J. A., Kriek, N., & Newbold, C. I. (1999). Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.16.9333
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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