The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Antigenic Variation in Plasmodium falciparum
Abstract
The persistence of the human malaria parasite Plasmodium falciparum during blood stage proliferation in its host depends on the successive expression of variant molecules at the surface of infected erythrocytes. This variation is mediated by the differential control of a family of surface molecules termed PfEMP1 encoded by approximately 60 var genes. Each individual parasite expresses a single var gene at a time, maintaining all other members of the family in a transcriptionally silent state. PfEMP1/var enables parasitized erythrocytes to adhere within the microvasculature, resulting in severe disease. This review highlights key regulatory mechanisms thought to be critical for monoallelic expression of var genes. Antigenic variation is orchestrated by epigenetic factors including monoallelic var transcription at separate spatial domains at the nuclear periphery, differential histone marks on otherwise identical var genes, and var silencing mediated by telomeric heterochromatin. In addition, controversies surrounding var genetic elements in antigenic variation are discussed.
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“The second study showed that pairing a var promoter in its natural location with another promoter of a selectable drug marker gene approximately 4 kb downstream of the transcriptional start site leads to a constitutive transcription (truncated transcript of 7 kb) and uncoupling of the var promoter from mutually exclus…”
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Cited by
Nguyen, T.-N., von Seidlein, L., Nguyen, T.-V., Truong, P.-N., Hung, S. D., Pham, H.-T., Nguyen, T.-U., Le, T. D., Dao, V. H., Mukaka, M., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30046-x · Cited by 121
Sander, A. F., Salanti, A., Lavstsen, T., Nielsen, M. A., Theander, T. G., Leke, R. G. F., Lo, Y. Y., Bobbili, N., Arnot, D. E., & Taylor, D. W. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir168 · Cited by 25
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Pathophysiology of Severe Malaria Infection
Ohiagu, F. O., Chikezie, P. C., Ahaneku, C. C., Chikezie, C. M., & Law-Obi, F. C. (2021) · Asian Journal of Health Sciences · doi:10.15419/ajhs.v7i2.492 · Cited by 21
Metadata
- Authors
- Scherf, A., Lopez-Rubio, J. J., & Riviere, L.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2008-10-01
- Volume
- 62
- Issue
- 1
- Pages
- 445-470
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2107046226
- Cited by
- 447
- References
- 10
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
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