The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP 2
Open accessAbstract
Female mice lacking the gene encoding the prostaglandin (PG) E 2 receptor subtype EP 2 (EP 2 −/− ) become pregnant and deliver their pups at term, but with a much reduced litter size. A decrease in ovulation number and a much reduced fertilization rate were observed in EP 2 −/− females without difference of the uterus to support implantation of wild-type embryos. Treatment with gonadotropins induced EP 2 mRNA expression in the cumulus cells of ovarian follicles of wild-type mice. The immature cumuli oophori from wild-type mice expanded in vitro in response to both follicle-stimulating hormone and PGE 2 , but the response to PGE 2 was absent in those from EP 2 −/− mice. Cumulus expansion proceeded normally in preovulatory follicles but became abortive in a number of ovulated complexes in EP 2 −/− mice, indicating that EP 2 is involved in cumulus expansion in the oviduct in vivo . No difference in the fertilization rate between wild-type and EP 2 −/− mice was found in in vitro studies using cumulus-free oocytes. These results indicate that PGE 2 cooperates with gonadotropin to complete cumulus expansion for successful fertilization.
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Cites
McMahon, F. G. (1986) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1986.35.673 · Cited by 2,215
Maeda, K.-I., Ohkura, S., & Tsukamura, H. (2000) · The Laboratory Rat · doi:10.1016/b978-012426400-7.50048-0 · Cited by 2,127
Manipulating the Mouse Embryo: A Laboratory Manual
Behringer, R. R., Gertsenstein, M., Nagy, K. V., & Nagy, A. (2002) · Cited by 2,046
Coleman, R. A., Smith, W. L., & Narumiya, S. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06784-5 · Cited by 1,735
Self-citationMultiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice
Lim, H., Paria, B. C., Das, S. K., Dinchuk, J. E., Langenbach, R., Trzaskos, J. M., & Dey, S. K. (1997) · Cell · doi:10.1016/s0092-8674(00)80402-x · Cited by 1,430
Comprehensive Medicinal Chemistry
(1991) · Quantitative Structure-Activity Relationships · doi:10.1002/qsar.19910100410 · Cited by 745
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
Ushikubi, F., Segi, E., Sugimoto, Y., Murata, T., Matsuoka, T., Kobayashi, T., Hizaki, H., Tuboi, K., Katsuyama, M., Ichikawa, A., et al. (1998) · Nature · doi:10.1038/26233 · Cited by 677
Self-citationYamamoto, K., Arakawa, T., Ueda, N., & Yamamoto, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31315 · Cited by 647
Tanaka, T., Akira, S., Yoshida, K., Umemoto, M., Yoneda, Y., Shirafuji, N., Fujiwara, H., Suematsu, S., Yoshida, N., & Kishimoto, T. (1995) · Cell · doi:10.1016/0092-8674(95)90418-2 · Cited by 528
Self-citationIntercommunication between mammalian oocytes and companion somatic cells
Eppig, J. J. (1991) · BioEssays · doi:10.1002/bies.950131105 · Cited by 456
Cited by
Prostanoid Receptors: Subtypes and Signaling
Breyer, R. M., Bagdassarian, C. K., Myers, S. A., & Breyer, M. D. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.661 · Cited by 1,011
Yan, C., Wang, P., DeMayo, J. L., DeMayo, F. J., Elvin, J. A., Cariño, C., Prasad, S. V., Skinner, S. M., Dunbar, B. S., Dube, J. L., et al. (2001) · Molecular Endocrinology · doi:10.1210/me.15.6.854 · Cited by 835
Genetic dissection of mammalian fertility pathways
Matzuk, M. M., & Lamb, D. J. (2002) · Nature Cell Biology · doi:10.1038/ncb-nm-fertilitys41 · Cited by 579
Oocyte–somatic cell interactions during follicle development in mammals
Gilchrist, R. B., Ritter, L. J., & Armstrong, D. T. (2004) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2004.05.017 · Cited by 579
Yao, C., Sakata, D., Esaki, Y., Li, Y., Matsuoka, T., Kuroiwa, K., Sugimoto, Y., & Narumiya, S. (2009) · Nature Medicine · doi:10.1038/nm.1968 · Cited by 566
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Metadata
- Authors
- Hizaki, H., Segi, E., Sugimoto, Y., Hirose, M., Saji, T., Ushikubi, F., Matsuoka, T., Noda, Y., Tanaka, T., Yoshida, N., Narumiya, S., & Ichikawa, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-08-31
- Volume
- 96
- Issue
- 18
- Pages
- 10501-10506
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989926395
- Cited by
- 465
- References
- 24
- FWCI
- 25.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Hizaki, H., Segi, E., Sugimoto, Y., Hirose, M., Saji, T., Ushikubi, F., Matsuoka, T., Noda, Y., Tanaka, T., Yoshida, N., Narumiya, S., & Ichikawa, A. (1999). Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP 2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.18.10501
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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