The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation
Open accessAbstract
Brief periods of cardiac ischemia trigger protection from subsequent prolonged ischemia (preconditioning). ɛ Protein kinase C (ɛPKC) has been suggested to mediate preconditioning. Here, we describe an ɛPKC-selective agonist octapeptide, ψɛ receptor for activated C-kinase (ψɛRACK), derived from an ɛPKC sequence homologous to its anchoring protein, ɛRACK. Introduction of ψɛRACK into isolated cardiomyocytes, or its postnatal expression as a transgene in mouse hearts, increased ɛPKC translocation and caused cardio-protection from ischemia without any deleterious effects. Our data demonstrate that ɛPKC activation is required for protection from ischemic insult and suggest that small molecules that mimic this ɛPKC agonist octapeptide provide a powerful therapeutic approach to protect hearts at risk for ischemia.
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Simpson, P., & Savion, S. (1982) · Circulation Research · doi:10.1161/01.res.50.1.101 · Cited by 453
Cited by
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Chen, L., Hahn, H., Wu, G., Chen, C.-H., Liron, T., Schechtman, D., Cavallaro, G., Banci, L., Guo, Y., Bolli, R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191369098 · Cited by 538
Self-citationThe role of protein kinase C activation and the vascular complications of diabetes
DASEVCIMEN, N., & KING, G. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.04.016 · Cited by 494
Baines, C. P., Zhang, J., Wang, G.-W., Zheng, Y.-T., Xiu, J. X., Cardwell, E. M., Bolli, R., & Ping, P. (2002) · Circulation Research · doi:10.1161/01.res.0000012702.90501.8d · Cited by 429
Aley, K. O., Messing, R. O., Mochly-Rosen, D., & Levine, J. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04680.2000 · Cited by 332
Self-citationIntramitochondrial signaling: interactions among mitoKATP, PKCε, ROS, and MPT
Costa, A. D. T., & Garlid, K. D. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01189.2007 · Cited by 238
Metadata
- Authors
- Dorn, G. W., Souroujon, M. C., Liron, T., Chen, C.-H., Gray, M. O., Zhou, H. Z., Csukai, M., Wu, G., Lorenz, J. N., & Mochly-Rosen, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-10-26
- Volume
- 96
- Issue
- 22
- Pages
- 12798-12803
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012978268
- Cited by
- 359
- References
- 1
- FWCI
- 16.01
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Dorn, G. W., Souroujon, M. C., Liron, T., Chen, C.-H., Gray, M. O., Zhou, H. Z., Csukai, M., Wu, G., Lorenz, J. N., & Mochly-Rosen, D. (1999). Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.22.12798
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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