The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C
Open accessAbstract
We have identified a mechanism, mediated by the ε isozyme of protein kinase C (PKCε) in peripheral neurons, which may have a role in chronic inflammatory pain. Acute inflammation, produced by carrageenan injection in the rat hindpaw, produced mechanical hyperalgesia that resolved by 72 hr. However, for up to 3 weeks after carrageenan, injection of the inflammatory mediators prostaglandin E 2 or 5-hydroxytryptamine or of an adenosine A 2 agonist into the same site induced a markedly prolonged hyperalgesia (>24 hr compared with 5 hr or less in control rats not pretreated with carrageenan). A nonselective inhibitor of several PKC isozymes and a selective PKCε inhibitor antagonized this prolonged hyperalgesic response equally. Acute carrageenan hyperalgesia could be inhibited by PKA or PKG antagonists. However, these antagonists did not inhibit development of the hypersensitivity to inflammatory mediators. Our findings indicate that different second messenger pathways underlie acute and prolonged inflammatory pain.
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Cites
Inducible cyclooxygenase may have anti-inflammatory properties
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Self-citationTranscriptional and posttranslational plasticity and the generation of inflammatory pain
Woolf, C. J., & Costigan, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7723 · Cited by 555
Biological properties of carrageenan
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A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice
Khasar, S. G., Lin, Y.-H., Martin, A., Dadgar, J., McMahon, T., Wang, D., Hundle, B., Aley, K. O., Isenberg, W., McCarter, G., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80837-5 · Cited by 433
Self-citationThe pathophysiology of chronic pain — increased sensitivity to low threshold Aβ-fibre inputs
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Self-citationDelayed Muscle Soreness: The Inflammatory Response to Muscle Injury and its Clinical Implications
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Self-citationInterleukin‐8 as a mediator of sympathetic pain
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Self-citationRobichaux, W. G., Mei, F. C., Yang, W., Wang, H., Sun, H., Zhou, Z., Milewicz, D. M., Teng, B.-B., & Cheng, X. (2020) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.314238 · Cited by 37
Subliminal (latent) processing of pain and its evolution to conscious awareness
Borsook, D., Youssef, A. M., Barakat, N., Sieberg, C. B., & Elman, I. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.015 · Cited by 21
Metadata
- Authors
- Aley, K. O., Messing, R. O., Mochly-Rosen, D., & Levine, J. D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-06-15
- Volume
- 20
- Issue
- 12
- Pages
- 4680-4685
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1709837271
- Cited by
- 332
- References
- 32
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Aley, K. O., Messing, R. O., Mochly-Rosen, D., & Levine, J. D. (2000). Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-12-04680.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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