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Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
Open accessAbstract
Pax6 , a highly conserved member of the paired homeodomain transcription factor family that plays essential roles in ocular, neural, and pancreatic development and effects asymmetric transient dorsal expression during pituitary development, with its expression extinguished before the ventral → dorsal appearance of specific cell types. Analysis of pituitary development in the Small eye and Pax6 −/− mouse mutants reveals that the dorsoventral axis of the pituitary gland becomes ventralized, with dorsal extension of the transcriptional determinants of ventral cell types, particularly PFrk . This ventralization is followed by a marked decrease in terminally differentiated dorsal somatotrope and lactotrope cell types and a marked increase in the expression of markers of the ventral thyrotrope cells and SF-1-expressing cells of gonadotrope lineage. We suggest that the transient dorsal expression of Pax6 is essential for establishing a sharp boundary between dorsal and ventral cell types, based on the inhibition of Shh ventral signals.
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Luo, X., Ikeda, Y., & Parker, K. L. (1994) · Cell · doi:10.1016/0092-8674(94)90211-9 · Cited by 1,631
Cited by
Pituitary Development: Regulatory Codes in Mammalian Organogenesis
Scully, K. M., & Rosenfeld, M. G. (2002) · Science · doi:10.1126/science.1062736 · Cited by 401
Self-citationOsumi, N., Shinohara, H., Numayama-Tsuruta, K., & Maekawa, M. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0884 · Cited by 344
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
van den Brink, G. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00054.2006 · Cited by 301
Hedgehog signaling is required for pituitary gland development
Treier, M., O’Connell, S., Gleiberman, A., Price, J., Szeto, D. P., Burgess, R., Chuang, P.-T., McMahon, A. P., & Rosenfeld, M. G. (2001) · Development · doi:10.1242/dev.128.3.377 · Cited by 299
Self-citationThe neuroendocrine system of invertebrates: a developmental and evolutionary perspective
Hartenstein, V. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06964 · Cited by 286
Metadata
- Authors
- Kioussi, C., O’Connell, S., St-Onge, L., Treier, M., Gleiberman, A. S., Gruss, P., & Rosenfeld, M. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-12-07
- Volume
- 96
- Issue
- 25
- Pages
- 14378-14382
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2154707264
- Cited by
- 158
- References
- 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Kioussi, C., O’Connell, S., St-Onge, L., Treier, M., Gleiberman, A. S., Gruss, P., & Rosenfeld, M. G. (1999). Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.25.14378
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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