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Cited by 344

The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.

Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator

Open access
Osumi, Noriko, Shinohara, Hiroshi, Numayama-Tsuruta, Keiko, Maekawa, Motoko·2008·Stem Cells

Abstract

Pax6 is a highly conserved transcription factor among vertebrates and is important in various developmental processes in the central nervous system (CNS), including patterning of the neural tube, migration of neurons, and formation of neural circuits. In this review, we focus on the role of Pax6 in embryonic and postnatal neurogenesis, namely, production of new neurons from neural stem/progenitor cells, because Pax6 is intensely expressed in these cells from the initial stage of CNS development and in neurogenic niches (the subgranular zone of the hippocampal dentate gyrus and the subventricular zone of the lateral ventricle) throughout life. Pax6 is a multifunctional player regulating proliferation and differentiation through the control of expression of different downstream molecules in a highly context-dependent manner. Disclosure of potential conflicts of interest is found at the end of this article.

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Metadata

Authors
Osumi, N., Shinohara, H., Numayama-Tsuruta, K., & Maekawa, M.
Venue
Stem Cells
Published
2008-05-08
Volume
26
Issue
7
Pages
1663-1672
ISSN
  • 1066-5099 (ISSN-L)
  • 1549-4918
OpenAlex
W2088704425
Cited by
344
References
136
FWCI
6.08
Type
journal article
Language
en
Open access
bronze

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Osumi, N., Shinohara, H., Numayama-Tsuruta, K., & Maekawa, M. (2008). Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator. Stem Cells. https://doi.org/10.1634/stemcells.2007-0884

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