The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor α (RAR α ) and oncogenic RAR α fusion proteins
Open accessAbstract
Analyzing the pathways by which retinoic acid (RA) induces promyelocytic leukemia/retinoic acid receptor α (PML/RAR α ) catabolism in acute promyelocytic leukemia (APL), we found that, in addition to caspase-mediated PML/RAR α cleavage, RA triggers degradation of both PML/RAR α and RAR α . Similarly, in non-APL cells, RA directly targeted RAR α and RAR α fusions to the proteasome degradation pathway. Activation of either RAR α or RXR α by specific agonists induced degradation of both proteins. Conversely, a mutation in RAR α that abolishes heterodimer formation and DNA binding, blocked both RAR α and RXR α degradation. Mutations in the RAR α DNA-binding domain or AF-2 transcriptional activation region also impaired RAR α catabolism. Hence, our results link transcriptional activation to receptor catabolism and suggest that transcriptional up-regulation of nuclear receptors by their ligands may be a feedback mechanism allowing sustained target-gene activation.
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Cites
Rochette-Egly, C., Adam, S., Rossignol, M., Egly, J.-M., & Chambon, P. (1997) · Cell · doi:10.1016/s0092-8674(00)80317-7 · Cited by 308
Self-citationPhosphorylation of the retinoic acid receptor-alpha by protein kinase A
Rochette-Egly, C. (1995) · Molecular Endocrinology · doi:10.1210/me.9.7.860 · Cited by 124
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Vazquez, F., Ramaswamy, S., Nakamura, N., & Sellers, W. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5010-5018.2000 · Cited by 774
Nuclear retinoid receptors and the transcription of retinoid-target genes
Bastien, J., & Rochette-Egly, C. (2004) · Gene · doi:10.1016/j.gene.2003.12.005 · Cited by 773
Self-citationOverview of nomenclature of nuclear receptors
Germain, P., Staels, B., Dacquet, C., Spedding, M., & Laudet, V. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.2 · Cited by 688
Targeted protein degradation: from mechanisms to clinic
Tsai, J. M., Nowak, R. P., Ebert, B. L., & Fischer, E. S. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00729-9 · Cited by 438
The Human Tumor Antigen PRAME Is a Dominant Repressor of Retinoic Acid Receptor Signaling
Epping, M. T., Wang, L., Edel, M. J., Carlée, L., Hernandez, M., & Bernards, R. (2005) · Cell · doi:10.1016/j.cell.2005.07.003 · Cited by 432
Metadata
- Authors
- Zhu, J., Gianni, M., Kopf, E., Honoré, N., Chelbi-Alix, M., Koken, M., Quignon, F., Rochette-Egly, C., & de Thé, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-12-21
- Volume
- 96
- Issue
- 26
- Pages
- 14807-14812
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1909732837
- Cited by
- 372
- References
- 2
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Zhu, J., Gianni, M., Kopf, E., Honoré, N., Chelbi-Alix, M., Koken, M., Quignon, F., Rochette-Egly, C., & de Thé, H. (1999). Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor α (RAR α ) and oncogenic RAR α fusion proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.26.14807
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