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The human natural killer cell immune synapse
Open accessAbstract
Inhibitory killer Ig-like receptors (KIR) at the surface of natural killer (NK) cells induced clustering of HLA-C at the contacting surface of target cells. In this manner, inhibitory immune synapses were formed as human NK cells surveyed target cells. At target/NK cell synapses, HLA-C/KIR distributed into rings around central patches of intercellular adhesion molecule-1/lymphocyte function-associated antigen-1, the opposite orientation to mature murine T cell-activating synapses. This organization of protein was stable for at least 20 min. Cells could support multiple synapses simultaneously, and clusters of HLA-C moved as NK cells crawled over target cells. Clustering required a divalent metal cation, explaining how metal chelators inhibit KIR function. Surprisingly, however, formation of inhibitory synapses was unaffected by ATP depletion and the cytoskeletal inhibitors, colchicine and cytochalsins B and D. Clearly, supramolecular organization within plasma membranes is critical for NK cell immunosurveillance.
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Cited by
Lanier, L. L. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115526 · Cited by 2,769
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
Mandelboim, O., Lieberman, N., Lev, M., Paul, L., Arnon, T. I., Bushkin, Y., Davis, D. M., Strominger, J. L., Yewdell, J. W., & Porgador, A. (2001) · Nature · doi:10.1038/35059110 · Cited by 990
Self-citationKIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity
Vilches, C., & Parham, P. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.092501.134942 · Cited by 986
Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Orange, J. S., Ramesh, N., Remold-O'Donnell, E., Sasahara, Y., Koopman, L., Byrne, M., Bonilla, F. A., Rosen, F. S., Geha, R. S., & Strominger, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162376099 · Cited by 295
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Metadata
- Authors
- Davis, D. M., Chiu, I., Fassett, M., Cohen, G. B., Mandelboim, O., & Strominger, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-12-21
- Volume
- 96
- Issue
- 26
- Pages
- 15062-15067
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117918558
- Cited by
- 416
- References
- 0
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Davis, D. M., Chiu, I., Fassett, M., Cohen, G. B., Mandelboim, O., & Strominger, J. L. (1999). The human natural killer cell immune synapse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.26.15062
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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