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Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase
Open accessAbstract
One of the genes that is up-regulated by thyroid hormone (TH) during Xenopus laevis metamorphosis encodes a type III deiodinase (D3) that inactivates TH. Transgenic X. laevis tadpoles overexpressing a GFP-D3 fusion protein were produced. These transgenic tadpoles had high levels of deiodinase activity and were resistant to exogenous TH added 1 week after fertilization. They developed normally throughout embryogenesis and premetamorphic stages but became retarded in their development late in prometamorphosis when endogenous TH reaches its highest level. Gill and tail resorption were delayed and most of the animals arrested and died. One tadpole completed its metamorphosis without resorbing its tail. These results demonstrate that D3 can modulate the action of TH in vivo , and document the value of the new transgenic method for functional analysis of genes involved in metamorphosis.
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Cited by
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Brown, D. D., & Cai, L. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.021 · Cited by 498
Self-citationAction of thyroid hormone in brain
Bernal, J. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344003 · Cited by 358
Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges
St. Germain, D. L., Galton, V. A., & Hernandez, A. (2009) · Endocrinology · doi:10.1210/en.2008-1588 · Cited by 297
Gereben, B., Zeöld, A., Dentice, M., Salvatore, D., & Bianco, A. C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7396-0 · Cited by 207
Metadata
- Authors
- Huang, H., Marsh-Armstrong, N., & Brown, D. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-02-02
- Volume
- 96
- Issue
- 3
- Pages
- 962-967
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060753854
- Cited by
- 162
- References
- 0
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase. https://app.cochat.ai/papers/10.1073/pnas.96.3.962
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- Huang, H., Marsh-Armstrong, N., & Brown, D. D. (1999). Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.3.962
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