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Cited by 297

The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.

Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges

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St. Germain, Donald L., Galton, Valerie Anne, Hernandez, Arturo·2009·Endocrinology
DOI 10.1210/en.2008-1588
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Abstract

As is typical of other hormone systems, the actions of the thyroid hormones (TH) differ from tissue to tissue depending upon a number of variables. In addition to varying expression levels of TH receptors and transporters, differing patterns of TH metabolism provide a critical mechanism whereby TH action can be individualized in cells depending on the needs of the organism. The iodothyronine deiodinases constitute a family of selenoenzymes that selectively remove iodide from thyroxine and its derivatives, thus activating or inactivating these hormones. Three deiodinases have been identified, and much has been learned regarding the differing structures, catalytic activities, and expression patterns of these proteins. Because of their differing properties, the deiodinases appear to serve varying functions that are important in regulating metabolic processes, TH action during development, and feedback control of the thyroid axis. This review will briefly assess these functional roles and others proposed for the deiodinases and examine some of the current challenges in expanding our knowledge of these important components of the thyroid homeostatic system. This review assesses the functional roles of TH action and others proposed for the deiodinases and examines current challenges in expanding knowledge of these components of the thyroid homeostatic system.

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Metadata

Authors
St. Germain, D. L., Galton, V. A., & Hernandez, A.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2009-01-29
Volume
150
Issue
3
Pages
1097-1107
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/en.2008-1588
OpenAlex
W1996180467
Cited by
297
References
127
FWCI
19.79
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges. https://app.cochat.ai/papers/10.1210/en.2008-1588
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St. Germain, D. L., Galton, V. A., & Hernandez, A. (2009). Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges. Endocrinology. https://doi.org/10.1210/en.2008-1588

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