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Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors
Open accessAbstract
We reported recently that the human opportunistic pathogen Pseudomonas aeruginosa strain PA14 kills Caenorhabditis elegans and that many P. aeruginosa virulence factors (genes) required for maximum virulence in mouse pathogenicity are also required for maximum killing of C. elegans. Here we report that among eight P. aeruginosa PA14 Tn phoA mutants isolated that exhibited reduced killing of C. elegans , at least five also exhibited reduced virulence in mice. Three of the Tn phoA mutants corresponded to the known virulence-related genes lasR, gacA , and lemA . Three of the mutants corresponded to known genes ( aefA from Escherichia coli, pstP from Azotobacter vinelandii , and mtrR from Neisseria gonorrhoeae ) that had not been shown previously to play a role in pathogenesis, and two of the mutants contained Tn phoA inserted into novel sequences. These data indicate that the killing of C. elegans by P. aeruginosa can be exploited to identify novel P. aeruginosa virulence factors important for mammalian pathogenesis.
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Cites
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Hogan, D. A., & Kolter, R. (2002) · Science · doi:10.1126/science.1070784 · Cited by 579
Déziel, E., Gopalan, S., Tampakaki, A. P., Lépine, F., Padfield, K. E., Saucier, M., Xiao, G., & Rahme, L. G. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04448.x · Cited by 417
Self-citationKurz, C. L. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg159 · Cited by 371
Gooderham, W. J., & Hancock, R. E. W. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00135.x · Cited by 346
Metadata
- Authors
- Tan, M.-W., Rahme, L. G., Sternberg, J. A., Tompkins, R. G., & Ausubel, F. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-03-02
- Volume
- 96
- Issue
- 5
- Pages
- 2408-2413
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005222994
- Cited by
- 629
- References
- 1
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Tan, M.-W., Rahme, L. G., Sternberg, J. A., Tompkins, R. G., & Ausubel, F. M. (1999). Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.5.2408
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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