The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytosolic phospholipase A2is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells
Open accessAbstract
We have used mice in which the gene for cytosolic phospholipase A 2(cPLA 2) has been disrupted to demonstrate the absolute requirement for cPLA 2 in both the immediate and the delayed phases of eicosanoid generation by bone marrow-derived mast cells. For the immediate phase, quantitative analysis of the products of the 5-lipoxygenase pathway showed that gene disruption of cPLA 2 prevented the provision of arachidonic acid substrate for biosynthesis of proximal intermediates. By analogy, we conclude that arachidonic acid substrate was also not available to prostaglandin endoperoxide synthase 1 in the immediate phase of prostaglandin (PG) D 2 generation. These defects occurred with two distinct stimuli, stem cell factor and IgE/antigen, which were, however, sufficient for signal transduction defined by exocytosis of β-hexosaminidase. Whereas cPLA 2 is essential for immediate eicosanoid generation by providing arachidonic acid, its role in delayed-phase PGD 2 generation is more complex and involves the activation-dependent induction of prostaglandin endoperoxide synthase 2 and the supply of arachidonic acid for metabolism to PGD 2.
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Clark, J. D., Lin, L.-L., Kriz, R. W., Ramesha, C. S., Sultzman, L. A., Lin, A. Y., Milona, N., & Knopf, J. L. (1991) · Cell · doi:10.1016/0092-8674(91)90556-e · Cited by 1,688
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Newton, K., & Dixit, V. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006049 · Cited by 1,513
Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964
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Long, J. Z., & Cravatt, B. F. (2011) · Chemical Reviews · doi:10.1021/cr200075y · Cited by 425
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Metadata
- Authors
- Fujishima, H., Sanchez Mejia, R. O., Bingham, C. O., Lam, B. K., Sapirstein, A., Bonventre, J. V., Austen, K. F., & Arm, J. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-04-27
- Volume
- 96
- Issue
- 9
- Pages
- 4803-4807
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2145109462
- Cited by
- 187
- References
- 1
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cytosolic phospholipase A2is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. https://app.cochat.ai/papers/10.1073/pnas.96.9.4803
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- Fujishima, H., Sanchez Mejia, R. O., Bingham, C. O., Lam, B. K., Sapirstein, A., Bonventre, J. V., Austen, K. F., & Arm, J. P. (1999). Cytosolic phospholipase A2is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.9.4803
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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