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In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers
Open accessAbstract
Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Ho x @C 82 (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Ho x @C 82 (OH) y . This metallofullerol was then neutron-activated ( 165 Ho[n,γ] 166 Ho) to prepare the 166 Ho x @C 82 (OH) y analog as a radiotracer, which was monitored, after intravenous administration, for up to 48 hours by using dissection radioanalysis, and its biodistribution was compared with a control compound, Na 2 [ 166 Ho(DTPA)(H 2 O)]. Results showed selective localization of the 166 Ho x @C 82 (OH) y tracer in the liver but with slow clearance, as well as uptake by bone without clearance. In contrast, excretion of the control compound was nearly quantitative after 1 hour. The fate of 166 Ho was also explored by a metabolism study of 166 Ho x @C 82 (OH) y in Fischer rats. Results indicated 20% excretion of intact 166 Ho x @C 82 (OH) y within 5 days. The present findings demonstrate the feasibility of using water-solubilized metallofullerene radiotracers to monitor the fate of fullerene-based materials in animals, and suggest that water-solubilized fullerene materials, in general, may be useful components in drug design.
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Cites
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Lasic, D. D., & Needham, D. (1995) · Chemical Reviews · doi:10.1021/cr00040a001 · Cited by 416
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Assessing the Risks of Manufactured Nanomaterials
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Metadata
- Authors
- Cagle, D. W., Kennel, S. J., Mirzadeh, S., Alford, J. M., & Wilson, L. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-04-27
- Volume
- 96
- Issue
- 9
- Pages
- 5182-5187
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011688365
- Cited by
- 303
- References
- 1
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Cagle, D. W., Kennel, S. J., Mirzadeh, S., Alford, J. M., & Wilson, L. J. (1999). In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.9.5182
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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