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Mouse numb is an essential gene involved in cortical neurogenesis
Open accessAbstract
During neurogenesis of the mammalian neocortex, neural progenitor cells divide to generate daughter cells that either become neurons or remain as progenitor cells. The mouse numb ( m-numb ) gene encodes a membrane-associated protein that is asymmetrically localized to the apical cell membrane of dividing cortical progenitor cells and may be segregated to only the apical daughter cell that has been suggested to remain as a progenitor cell. To examine m-numb function during neural development, we generated a loss-of-function mutant allele of m-numb . Mice homozygous for this mutation exhibit severe defects in cranial neural tube closure and precocious neuron production in the forebrain and die around embryonic day 11.5 (E11.5). These findings suggest that m-numb is an essential gene that plays a role in promoting progenitor cell fate during cortical neurogenesis.
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Citations
Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127
Cited by
The genetic basis of mammalian neurulation
Copp, A. J., Greene, N. D. E., & Murdoch, J. N. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1181 · Cited by 697
Notch signaling in the mammalian central nervous system: insights from mouse mutants
Yoon, K., & Gaiano, N. (2005) · Nature Neuroscience · doi:10.1038/nn1475 · Cited by 587
McGill, M. A., & McGlade, C. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302827200 · Cited by 457
Imai, T., Tokunaga, A., Yoshida, T., Hashimoto, M., Mikoshiba, K., Weinmaster, G., Nakafuku, M., & Okano, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3888-3900.2001 · Cited by 454
Schwamborn, J. C., Berezikov, E., & Knoblich, J. A. (2009) · Cell · doi:10.1016/j.cell.2008.12.024 · Cited by 414
Metadata
- Authors
- Zhong, W., Jiang, M.-M., Schonemann, M. D., Meneses, J. J., Pedersen, R. A., Jan, L. Y., & Jan, Y. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-06-06
- Volume
- 97
- Issue
- 12
- Pages
- 6844-6849
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117856743
- Cited by
- 186
- References
- 1
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhong, W., Jiang, M.-M., Schonemann, M. D., Meneses, J. J., Pedersen, R. A., Jan, L. Y., & Jan, Y. N. (2000). Mouse numb is an essential gene involved in cortical neurogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.12.6844
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