The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors
Open accessAbstract
SUMMARY In the mouse neocortex, neural progenitor cells generate both differentiating neurons and daughter cells that maintain progenitor fate. Here, we show that the TRIM-NHL protein TRIM32 regulates protein degradation and microRNA activity to control the balance between those two daughter cell types. In both horizontally and vertically dividing progenitors, TRIM32 becomes polarized in mitosis and is concentrated in one of the two daughter cells. TRIM32 overexpression induces neuronal differentiation while inhibition of TRIM32 causes both daughter cells to retain progenitor cell fate. TRIM32 ubiquitinates and degrades the transcription factor c-Myc but also binds Argonaute-1 and thereby increases the activity of specific microRNAs. We show that Let-7 is one of the TRIM32 targets and is required and sufficient for neuronal differentiation. TRIM32 is the mouse ortholog of Drosophila Brat and Mei-P26 and might be part of a protein family that regulates the balance between differentiation and proliferation in stem cell lineages.
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Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578
A skin microRNA promotes differentiation by repressing ‘stemness’
Yi, R., Poy, M. N., Stoffel, M., & Fuchs, E. (2008) · Nature · doi:10.1038/nature06642 · Cited by 790
Frosk, P., Weiler, T., Nylen, E., Sudha, T., Greenberg, C. R., Morgan, K., Fujiwara, T. M., & Wrogemann, K. (2002) · The American Journal of Human Genetics · doi:10.1086/339083 · Cited by 261 · cited 2×
“TRIM32 is mutated in patients carrying limb girdle muscular dystrophy type 2H (Frosk et al., 2002).”
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
Pan, L., Chen, S., Weng, C., Call, G., Zhu, D., Tang, H., Zhang, N., & Xie, T. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.09.010 · Cited by 211
Cited by
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
Regulation of mRNA Translation and Stability by microRNAs
Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214
Gibbings, D. J., Ciaudo, C., Erhardt, M., & Voinnet, O. (2009) · Nature Cell Biology · doi:10.1038/ncb1929 · Cited by 991
Hatakeyama, S. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3139 · Cited by 802
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
Chekulaeva, M., & Filipowicz, W. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.04.009 · Cited by 685
Metadata
- Authors
- Schwamborn, J. C., Berezikov, E., & Knoblich, J. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 136
- Issue
- 5
- Pages
- 913-925
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2166430233
- Cited by
- 414
- References
- 6
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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