The DOI matches its Crossref record; 104 of the 105 references it cites were found in a registry or an index.
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
Open accessAbstract
This review summarizes recent evidence from knock-out mice on the role of reactive oxygen intermediates and reactive nitrogen intermediates (RNI) in mammalian immunity. Reflections on redundancy in immunity help explain an apparent paradox: the phagocyte oxidase and inducible nitric oxide synthase are each nonredundant, and yet also mutually redundant, in host defense. In combination, the contribution of these two enzymes appears to be greater than previously appreciated. The remainder of this review focuses on a relatively new field, the basis of microbial resistance to RNI. Experimental tuberculosis provides an important example of an extended, dynamic balance between host and pathogen in which RNI play a major role. In diseases such as tuberculosis, a molecular understanding of host–pathogen interactions requires characterization of the defenses used by microbes against RNI, analogous to our understanding of defenses against reactive oxygen intermediates. Genetic and biochemical approaches have identified candidates for RNI-resistance genes in Mycobacterium tuberculosis and other pathogens.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In addition, NO causes the formation of reactive nitrogen species (such as peroxynitrite) which can damage mitochondrial function and which have been shown to have strong antifungal activity (26).”
From Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition (2019) · cites this paper as [26]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“iNOS catalyzed high output formation of the labile radical NO by macrophages (Nathan and Shiloh, 2000; Bogdan, 2001) which exerts direct anti-microbial effector functions.”
From Iron at the interface of immunity and infection (2014) · cites this paper as Nathan and Shiloh, 2000
In the citing paper
“Using arginine and oxygen, the homodimeric NOS2 generates NO and citrulline, as one subunit transfers electrons between NADPH, FAD, flavin mononucleotide to the heme iron of the second subunit (56, 57).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [56]
In the citing paper
“NOX2 consists of five catalytic subunits, which assemble after phagocytosis thereby forming an active enzymatic complex producing superoxide anions and hydrogen peroxide along with the formation of hydroxyl radicals, the latter pathway being catalyzed by iron via the Fenton reaction (56, 59–61).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [56]
In the citing paper
“Both NOX2/gp91 phox and iNOS/ NOS2 are prototypical hemoproteins that use Fe-heme to catalyze the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), respectively [76].”
From The Iron age of host–microbe interactions (2015) · cites this paper as [76]
In the citing paper
“Moreover, extracellular hemoglobin may also exert protective effects based on NO and ONNO À detoxification [76,80,197].”
From The Iron age of host–microbe interactions (2015) · cites this paper as [76]
In the citing paper
“For example, generation of nitric oxide (NO•) by the inducible nitric oxide synthase (iNOS/NOS2) is a well established host defense mechanism that confers resistance to Salmonella, Leishmania or Mycobacteria (62).”
From Innate Nutritional Immunity (2018) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
Self-citationNITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245
Self-citationPeroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A., & Bloom, B. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2249 · Cited by 2,468
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.
Dalton, D., Pitts-Meek, S., Keshav, S., Figari, I., Bradley, A., & Stewart, T. (1993) · Science · doi:10.1126/science.8456300 · Cited by 2,015
Nitric oxide functions as a signal in plant disease resistance
Delledonne, M., Xia, Y., Dixon, R. A., & Lamb, C. J. (1998) · Nature · doi:10.1038/29087 · Cited by 1,859
Flynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schrelber, R., Mak, T. W., & Bloom, B. R. (1995) · Immunity · doi:10.1016/1074-7613(95)90001-2 · Cited by 1,678
Immune Response in Mice that Lack the Interferon-γ Receptor
Huang, S., Hendriks, W. J. A. J., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilček, J., Zinkernagel, R. M., & Aguet, M. (1993) · Science · doi:10.1126/science.8456301 · Cited by 1,551
Defense gene induction in tobacco by nitric oxide, cyclic GMP, and cyclic ADP-ribose
Durner, J., Wendehenne, D., & Klessig, D. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10328 · Cited by 1,320
DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors
Wink, D. A., Kasprzak, K. S., Maragos, C. M., Elespuru, R. K., Misra, M., Dunams, T. M., Cebula, T. A., Koch, W. H., Andrews, A. W., Allen, J. S., et al. (1991) · Science · doi:10.1126/science.1948068 · Cited by 1,243
Research works printed but not linked: 6
- S J Klebanoff Inflammation, eds J I Gallin, R Snyderman, D T Fearon, B F Haynes, C Nathan (Lippincott, Philadelphia), pp. 721–768 (1999).
- P Elsbach, J Weiss, O Levy Inflammation, eds J I Gallin, R Snyderman, D T Fearon, B F Haynes, C Nathan (Lippincott, Philadelphia), pp. 801–818 (1999).
- M A DeGroote, F C Fang Nitric Oxide and Infection, ed F C Fang (Kluwer/Plenum, New York), pp. 231–264 (1999).
- J Chan, J Flynn Nitric Oxide and Infection, ed F C Fang (Kluwer/Plenum, New York), pp. 281–310 (1999).
- B Gaston, J S Stamler Nitric Oxide and Infection, ed F C Fang (Kluwer/Plenum, New York), pp. 37–55 (1999).
- Bryk R. Griffin P. & Nathan C. (2000) Nature (London) in press.
Cited by
Sorted by citations
Items 801–900 of 1,000
Shi, L., Sohaskey, C. D., North, R. J., & Gennaro, M. L. (2007) · Tuberculosis · doi:10.1016/j.tube.2007.08.007 · Cited by 22
Glinski, A., Liebel, S., Pelletier, É., Voigt, C. L., Randi, M. A. F., de Campos, S. X., Ribeiro, C. A. D. O., & Neto, F. F. (2016) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2016.1159770 · Cited by 22
Shrimp Immune System and Immune Responses
Rajendran, K. V., Sreedharan, K., Deepika, A., & Kulkarni, A. D. (2022) · Springer eBooks · doi:10.1007/978-981-19-1268-9_2 · Cited by 22
DNA repair mechanisms and Toxoplasma gondii infection
Smolarz, B., Wilczyński, J., & Nowakowska, D. (2013) · Archives of Microbiology · doi:10.1007/s00203-013-0944-0 · Cited by 21
Sharma, D., Tiwari, B. K., Mehto, S., Antony, C., Kak, G., Singh, Y. P., & Natarajan, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163845 · Cited by 21
Kumar, A., Singh, S. M., Singh, R., & Kaur, J. (2017) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2017.01.003 · Cited by 21
Passos, L. S. A., Gazzinelli-Guimarães, P. H., Mendes, T. A. D. O., Guimarães, A. C. G., Silveira-Lemos, D., Ricci, N. D., Gonçalves, R., Bartholomeu, D. C., Fujiwara, R. T., & Bueno, L. L. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2366-0 · Cited by 22
Kim, V. Y., Batty, A. J., Li, J., Kirk, S. G., Crowell, S. A., Jin, Y., Tang, J., Zhang, J., Rogers, L. K., Deng, H., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1701686 · Cited by 21
New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053
Chiarelli, L. R., Salina, E. G., Mori, G., Azhikina, T. L., Riabova, O., Lepioshkin, A., Grigorov, A., Forbak, M., Madacki, J., Orena, B. S., et al. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00388 · Cited by 21
Surveying the damage: the challenges of developing nucleic acidbiomarkers of inflammation
Son, J., Pang, B., McFaline‐Figueroa, J. L., Taghizadeh, K., & Dedon, P. C. (2008) · Molecular BioSystems · doi:10.1039/b719411k · Cited by 21
Pravansha, S., Thippeswamy, B. S., & Veerapur, V. P. (2012) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2012.689767 · Cited by 21
KHANDUJA, K. L., Avti, P., & KUMARVANDANAPATHANIACHANDERMOHANP, S. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.09.037 · Cited by 21
Superoxide Generation and Its Involvement in the Growth of Mycobacterium smegmatis
Yeware, A. M., Shurpali, K., Athalye, M. C., & Sarkar, D. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00105 · Cited by 21
Yang, C., Wang, J., & Zou, L. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5220 · Cited by 22
Virulence insights from the Paracoccidioides brasiliensis transcriptome.
Tavares, A. H., Titze-de-Almeida, S. S., Bernardes, V. V., Maranhão, A. Q., Kyaw, C. M., Poças-Fonseca, M. J., & Silva-Pereira, I. (2005) · PubMed · Cited by 21
Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells
Ferlito, M., Irani, K., Faraday, N. R., & Lowenstein, C. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600275103 · Cited by 21
Nikolaou, A., Salvador, M., Wright, I. P., Wantock, T., Sandison, G., Harle, T., Carta, D., & Gutierrez‐Merino, J. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127986 · Cited by 20
Mycobacterium avium Subsp. hominissuis Interactions with Macrophage Killing Mechanisms
Abukhalid, N. F., Islam, S., Ndzeidze, R., & Bermudez, L. E. (2021) · Pathogens · doi:10.3390/pathogens10111365 · Cited by 21
Khan, H., Paul, P., Sevalkar, R. R., Kachhap, S., Singh, B., & Sarkar, D. (2022) · eLife · doi:10.7554/elife.80965 · Cited by 20
Striking the Right Balance Determines TB or Not TB
Dasgupta, S. B., & Pieters, J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00455 · Cited by 21
Potential role of thiol:disulfide oxidoreductases in the pathogenesis ofHelicobacter pylori
Kaakoush, N. O., Kovách, Z., & Mendz, G. L. (2007) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00259.x · Cited by 20
Liu, H., Xi, L., Zhang, J., Li, X., Liu, X., Lu, C., & Sun, J. (2007) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2007.00652.x · Cited by 20
Ny, L., Li, H., Mukherjee, S., Persson, K., Holmqvist, B. I., Zhao, D., Shtutin, V., Huang, H., Weiss, L. M., Machado, F. S., et al. (2008) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2008.79.760 · Cited by 20
Kawai, T., Tatsumi, S., Kihara, S., Sakimura, K., & Okamura, Y. (2017) · Channels · doi:10.1080/19336950.2017.1385684 · Cited by 20
Samarasinghe, H., Aceituno-Caicedo, D., Cogliati, M., Kwon-Chung, K. J., Rickerts, V., Velegraki, A., Akçağlar, S., & Xu, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-27813-3 · Cited by 20
Handorf, O., Below, H., Schnabel, U., Riedel, K., & Ehlbeck, J. (2020) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/ab866b · Cited by 20
Acute and Chronic Inflammation
(2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0792-2.50007-9 · Cited by 20
Amatore, C. A., Arbault, S., & Erard, M. (2008) · Analytical Chemistry · doi:10.1021/ac801269e · Cited by 20
Mixed cytokine profile during active cutaneous leishmaniasis and in natural resistance
Baratta-Masini, A. (2006) · Frontiers in bioscience · doi:10.2741/2106 · Cited by 20
Rifampin Augments Cytokine-Induced Nitric Oxide Production in Human Alveolar Epithelial Cells
Yuhas, Y., Berent, E., Ovadiah, H., Azoulay, I., & Ashkenazi, S. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.1.396-398.2006 · Cited by 20
Deciphering the oxidative stress response in Candida albicans
Arribas, V., Gil, C., & Molero, G. (2025) · Fungal Biology Reviews · doi:10.1016/j.fbr.2025.100427 · Cited by 20
Antileishmanial activity of 2-amino-thiophene derivative SB-200
de Sousa, J. P. A., de Sousa, J. M. S., Rodrigues, R. R. L., Nunes, T. A. D. L., Machado, Y. A. A., de Araújo, A. C., da Silva, I. G. M., Barros‐Cordeiro, K. B., Báo, S. N., Alves, M. M. D. M., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110750 · Cited by 19
Haniu, A. E. C. J., Maricato, J. T., Mathias, P. P. M., Castilho, D. G., Miguel, R. B., Monteiro, H. P., Puccia, R., & Batista, W. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069590 · Cited by 19
Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology
Forrester, M. T., Eyler, C. E., & Rich, J. N. (2011) · BioTechniques · doi:10.2144/000113586 · Cited by 19
Lipopolysaccharide (LPS) of Helicobacter modulates cellular DNA repair systems in intestinal cells
Cavallo, P., Cianciulli, A., Mitolo, V., & Panaro, M. A. (2010) · Clinical and Experimental Medicine · doi:10.1007/s10238-010-0118-1 · Cited by 19
Mina, S., Staerck, C., D'Almeida, S. M., Marot, A., Delneste, Y., Calenda, A., Tabiasco, J., Bouchara, J., & Fleury, M. J. J. (2015) · Fungal Biology · doi:10.1016/j.funbio.2015.09.007 · Cited by 19
Garcia, C. C., Tavares, L. P., Dias, A. C. F., Kehdy, F. S. G., Alvarado-Arnez, L. E., Queiroz‐Junior, C. M., Galvão, I., Lima, B. H. F., Matos, A. D. R., Gonçalves, A. P., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00975 · Cited by 19
Almeida-Souza, F., de Oliveira, A. E. R., Abreu‐Silva, A. L., & Calabrese, K. D. S. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3555-7 · Cited by 19
Davtyan, T. K., Manukyan, H. M., Mkrtchyan, N. R., Avetisyan, S. A., & Galoyan, A. A. (2005) · NeuroImmunoModulation · doi:10.1159/000087105 · Cited by 19
Klug, K., Ehlers, S., Uhlig, S., & Reiling, N. (2010) · Innate Immunity · doi:10.1177/1753425910377799 · Cited by 19
Nitric oxide formation in the oropharyngeal tract: possible influence of cigarette smoking
Marteus, H., Mavropoulos, A., Palm, J., Ulfgren, A.-K., Bergström, J., & Alving, K. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.09.006 · Cited by 19
Reactive Species in Viral Pneumonitis: Lessons From Animal Models
Davis, I. C., & Matalon, S. (2001) · Physiology · doi:10.1152/physiologyonline.2001.16.4.185 · Cited by 19
Nitric oxide releases intracellular zinc from prokaryotic metallothionein in Escherichia coli
Binet, M. R. B., Cruz-Ramos, H., Laver, J. R., Hughes, M., & Poole, R. K. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11295.x · Cited by 19
Circulating cytokines in pulmonary tuberculosis according to HIV status and dietary iron content.
Gordeuk, V. R., Moyo, V. M., Nouraie, M. S., Gangaidzo, I. T., Murphree, N. L., Gomo, Z. A. R., Boelaert, J. R., & Weiß, G. (2009) · PubMed · Cited by 18
The role of nitrite ion in phagocyte function—perspectives and puzzles
Cape, J. L., & Hurst, J. K. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.01.010 · Cited by 18
Modulation of myocardial contraction by peroxynitrite
Kohr, M. J., Roof, S. R., Zweier, J. L., & Ziolo, M. T. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00468 · Cited by 18
S-Nitrosylation Signaling in Escherichia coli
Gusarov, I., & Nudler, E. (2012) · Science Signaling · doi:10.1126/scisignal.2003181 · Cited by 18
Oxygen and Oxygen Toxicity: The Birth of Concepts
Zhu, H., Santo, A., Trush, M. A., & Li, Y. R. (2016) · Reactive Oxygen Species · doi:10.20455/ros.2016.801 · Cited by 19
Mycobacterium tuberculosis: Macrophage Takeover and Modulation of Innate Effector Responses
Bhat, K. H., & Yaseen, I. (2018) · InTech eBooks · doi:10.5772/intechopen.75003 · Cited by 18
Mierzejewski, K., Paukszto, Ł., Kurzyńska, A., Kunicka, Z., Jastrzebski, J., Makowczenko, K. G., Golubska, M., & Bogacka, I. (2022) · Scientific Reports · doi:10.1038/s41598-022-07986-8 · Cited by 18
Lopes, F. C. M., Placeres, M. C. P., Jordão, C. M., Higuchi, C. T., Rinaldo, D., Vilegas, W., Leite, C. Q. F., & Carlos, I. Z. (2007) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762007000600018 · Cited by 18
Serum Paraoxonase 1 Activity and Oxidative Stress in Pediatric Patients with Pulmonary Tuberculosis
Torun, E., Gedik, A. H., Çakır, E., Umutoğlu, T., Gök, Ö., & Kılıç, Ü. (2014) · Medical Principles and Practice · doi:10.1159/000363700 · Cited by 18
Pavanelli, W. R., & da Silva, J. J. N. (2010) · The Open Nitric Oxide Journal · doi:10.2174/1875042701002010001 · Cited by 18
Chacón, O., Bermudez, L. E., Zinniel, D. K., Chahal, H. K., Fenton, R. J., Feng, Z., Hanford, K. J., Adams, L. G., & Barletta, R. G. (2009) · Microbiology · doi:10.1099/mic.0.024901-0 · Cited by 18
Zuccarella‐Hackl, C., von Känel, R., Thomas, L., Hauser, M., Kuebler, U., Widmer, H. R., & Wirtz, P. H. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000324 · Cited by 18
Idh, J., Andersson, B., Lerm, M., Raffetseder, J., Eklund, D., Woksepp, H., Werngren, J., Mansjö, M., Sundqvist, T., Stendahl, O. I., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181221 · Cited by 18
Khan, N., Ghousunnissa, S., Jegadeeswaran, S. M., Thiagarajan, D., Hasnain, S. E., & Mukhopadhyay, S. (2007) · International Immunology · doi:10.1093/intimm/dxm012 · Cited by 18
Academy of Science of South Africa (ASSAf) (2007) · doi:10.17159/assaf/0037 · Cited by 18
Park, S., Lee, H., & Cao, W. (2010) · Microbial Pathogenesis · doi:10.1016/j.micpath.2010.08.001 · Cited by 17
Understanding Staphylococcus aureus internalisation and induction of antimicrobial tolerance
Goormaghtigh, F., & Françoise Van Bambeke, A. (2024) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2024.2303018 · Cited by 18
Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis
Ansell, B. R. E., McConville, M. J., Baker, L., Korhonen, P. K., Emery‐Corbin, S. J., Svärd, S. G., Gasser, R. B., & Jex, A. R. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00977-16 · Cited by 18
Hutson, L. W., Lebonville, C. L., Jones, M., Fuchs, R. A., & Lysle, D. T. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.017 · Cited by 17
OhrR of Mycobacterium smegmatis senses and responds to intracellular organic hydroperoxide stress
Garnica, O., Das, K., & Dhandayuthapani, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-03819-1 · Cited by 17
Inherent Oxidative Stress in the Lewis Rat Is Associated with Resistance to Toxoplasmosis
Witola, W. H., Kim, C. Y., & Zhang, X. (2017) · Infection and Immunity · doi:10.1128/iai.00289-17 · Cited by 17
Dong, S., Hu, W., Ge, Y., Ojcius, D. M., Lin, X., & Yan, J. (2017) · Emerging Microbes & Infections · doi:10.1038/emi.2017.93 · Cited by 17
RetractedAnaerobic Transcription by OxyR: A Novel Paradigm for Nitrosative Stress
Seth, D., Hausladen, A., & Stamler, J. S. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7921 · Cited by 18
Concept about the Virulence Factor of Legionella
Yang, J.-L., Li, D., & Zhan, X.-Y. (2022) · Microorganisms · doi:10.3390/microorganisms11010074 · Cited by 17
Functional analysis of Borrelia burgdorferi uvrA in DNA damage protection
Sambir, M., Ivanova, L. B., Bryksin, A. V., Godfrey, H. P., & Cabello, F. C. (2011) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2011.02226.x · Cited by 17
Iron acquisition inLeishmaniaand its crucial role in infection
NIU, Q., Li, S., Chen, D., CHEN, Q., & Chen, J. (2016) · Parasitology · doi:10.1017/s0031182016000858 · Cited by 17
Seghatoleslam, A., Hemmati, M., Ebadat, S., Movahedi, B., & Mostafavi‐Pour, Z. (2016) · PubMed Central · Cited by 17
Yugami, M., Odagiri, H., Endo, M., Tsutsuki, H., Fujii, S., Kadomatsu, T., Masuda, T., Miyata, K., Terada, K., Tanoue, H., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.720870 · Cited by 17
Vanin, A. F. (2015) · Austin Journal of Reproductive Medicine & Infertility · doi:10.26420/austinjreprodmedinfertil.2015.1019 · Cited by 17
Zanganeh, E., Soudi, S., Hosseini, A. Z., & Khosrojerdi, A. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.10.008 · Cited by 17
Obesity-linked Insulin Resistance: Is Nitric Oxide the Missing Link?
Dallaire, P., & Marette, A. (2004) · Cited by 17
Kikuchi, H., Kim, S., Watanabe, K., & Watarai, M. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00253.x · Cited by 17
Das, K., la Garza, G. D., Maffi, S. K., Saikolappan, S., & Dhandayuthapani, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036247 · Cited by 17
Grassmann, A. A., Zavala-Alvarado, C., Bettin, E. B., Picardeau, M., Benaroudj, N., & Caimano, M. J. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009078 · Cited by 16
Importance of Oxidative Stress and Antioxidant System in Health and Disease
Sabuncuoğlu, S., & Yalçınkaya, A. S. (2022) · Biochemistry · doi:10.5772/intechopen.100949 · Cited by 16
Kumar, R., Gandham, S., Rana, A., Maity, H. K., Sarkar, U. K., & Dey, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1199092 · Cited by 16
Shan, Y., Lu, X., Han, Y., Li, X., Wang, X., Shao, C., Wang, L., Liu, Z., Tang, W., Sun, Y., et al. (2015) · BioMed Research International · doi:10.1155/2015/571280 · Cited by 16
Protection against peroxynitrite by pseudoperoxidase from Leishmania major
Bose, M., Saha, R., Santara, S. S., Mukherjee, S., Roy, J., & Adak, S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.583 · Cited by 16
The Potentials of Melatonin in the Prevention and Treatment of Bacterial Meningitis Disease
Zhang, D., Xu, S., Wang, Y., & Zhu, G. (2021) · Molecules · doi:10.3390/molecules26051419 · Cited by 16
Jiang, Q., & Shi, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.711462 · Cited by 16
High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase knockout rats
Wang, Z.-J., Yu, S.-M., Gao, J.-M., Zhang, P., Hide, G., Yamamoto, M., Lai, D., & Lun, Z. (2021) · iScience · doi:10.1016/j.isci.2021.103280 · Cited by 16
Nathan, C. (2011) · Cell · doi:10.1016/j.cell.2011.09.031 · Cited by 16
Self-citationEffect of nitric oxide on the growth ofChlamydophila pneumoniae
Carratelli, C. R., Rizzo, A., Paolillo, R., Catania, M. R., Catalanotti, P., & Rossano, F. (2005) · Canadian Journal of Microbiology · doi:10.1139/w05-080 · Cited by 16
Srivastava, A., Dwivedi, N., Samanta, U., & Sau, A. K. (2011) · IUBMB Life · doi:10.1002/iub.552 · Cited by 16
The Pup-Proteasome System of Mycobacteria
Bode, N. J., & Darwin, K. H. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.mgm2-0008-2013 · Cited by 17
Charyulu, E. M., & Gnanamani, A. (2010) · Current Research in Bacteriology · doi:10.3923/crb.2010.197.213 · Cited by 16
Huang, T., Huang, X., Shi, B., Wang, F., Feng, W., & Yao, M. (2018) · Veterinary Research · doi:10.1186/s13567-018-0616-9 · Cited by 18
Reactive Oxygen and Reactive Nitrogen Metabolites as Effector Molecules against Infectious Pathogens
Bogdan, C. (2014) · ASM Press eBooks · doi:10.1128/9781555817671.ch19 · Cited by 16
Soegiarto, L., & Wills, R. B. H. (2006) · Australian Journal of Experimental Agriculture · doi:10.1071/ea05059 · Cited by 16
The crystal structure of Rv0793, a hypothetical monooxygenase from M.␣tuberculosis
Lemieux, M. J., Ference, C., Cherney, M. M., Wang, M., Garen, C. R., & James, M. N. G. (2006) · Journal of Structural and Functional Genomics · doi:10.1007/s10969-005-9004-6 · Cited by 16
The role of nitric oxide in lung innate immunity: Modulation by surfactant protein-A
O’Reilly, P. J., Hickman‐Davis, J. M., McArdle, P. J., Young, K. R., & Matalon, S. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015996424256 · Cited by 16
Concerted activities of nitric oxide synthases and NADPH oxidases in PLB-985 cells
Verchier, Y., Lardy, B., Nguyen, M. V. C., Morel, F., Arbault, S., & Amatore, C. A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.041 · Cited by 16
The Role of Salicylic Acid and Nitric Oxide in Programmed Cell Death and Induced Resistance
Métraux, J., & Durner, J. (2004) · Ecological studies · doi:10.1007/978-3-662-08818-0_5 · Cited by 16
Nitric oxide-modulating biomaterials for therapeutic Immunoengineering
Boo, Y., Choi, S., Kim, J., & Kim, W. J. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115718 · Cited by 16
How Bacterial Redox Sensors Transmit Redox Signals via Structural Changes
Lee, I., & Lee, B. (2021) · Antioxidants · doi:10.3390/antiox10040502 · Cited by 15
Metacyclogenesis as the Starting Point of Chagas Disease
Ferreira, A., de Araújo, C. N., Cardoso, I. C. C., Mangabeira, K. S. D. S., Rocha, A. P., Charneau, S. O., Santana, J. M., Motta, F. N., & Bastos, I. M. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010117 · Cited by 16
Hu, K., Li, W., Wang, H., Chen, K., Wang, Y., & Sang, J. (2012) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2012.04.004 · Cited by 15
Metadata
- Authors
- Nathan, C., & Shiloh, M. U.
- Affiliations
- Cornell University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-08
- Volume
- 97
- Issue
- 16
- Pages
- 8841-8848
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC34021
- OpenAlex
- W2113120391
- Cited by
- 1,469
- References
- 105
- Citations by year
- 2026: 26 · 2025: 29 · 2024: 42 · 2023: 32 · 2022: 49 · 2021: 42 · 2020: 59 · 2019: 51 · 2018: 56 · 2017: 62 · 2016: 66 · 2015: 64 · 2014: 72 · 2013: 70 · 2012: 81
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- reactive oxygen species, reactive nitrogen intermediates, host-pathogen interaction, inducible nitric oxide synthase, NADPH oxidase, inducible nitric oxide, Mycobacterium tuberculosis, tuberculosis, knockout mice, innate immunity
- MeSH terms
- Animals, Humans, Mammals, Mycobacterium tuberculosis, Nitrogen, Reactive Oxygen Species, Nitric Oxide Synthase, NADPH Oxidases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
