The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Spinophilin regulates the formation and function of dendritic spines
Open accessAbstract
Spinophilin, a protein that interacts with actin and protein phosphatase-1, is highly enriched in dendritic spines. Here, through the use of spinophilin knockout mice, we provide evidence that spinophilin modulates both glutamatergic synaptic transmission and dendritic morphology. The ability of protein phosphatase-1 to regulate the activity of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N -methyl- d -aspartate (NMDA) receptors was reduced in spinophilin knockout mice. Consistent with altered glutamatergic transmission, spinophilin-deficient mice showed reduced long-term depression and exhibited resistance to kainate-induced seizures and neuronal apoptosis. In addition, deletion of the spinophilin gene caused a marked increase in spine density during development in vivo as well as altered filopodial formation in cultured neurons. In conclusion, spinophilin appears to be required for the regulation of the properties of dendritic spines.
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Cites
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905
An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression
Mulkey, R. M., Herron, C. E., & Malenka, R. C. (1993) · Science · doi:10.1126/science.8394601 · Cited by 699
Direct measurement of coupling between dendritic spines and shafts
Svoboda, K., Tank, D. W., & Denk, W. (1996) · Science · doi:10.1126/science.272.5262.716 · Cited by 472
Cited by
Dentritic spines : structure, dynamics and regulation
Hering, H., & Sheng, M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35104061 · Cited by 961
Estrogen Actions Throughout the Brain
McEwen, B. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.357 · Cited by 915
Protein phosphatase 1 – targeted in many directions
Cohen, P. T. W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.2.241 · Cited by 912
Lisman (2001) · doi:10.1016/s0896-6273(01)00364-6 · Cited by 480
Penzes, P., Beeser, A., Chernoff, J., Schiller, M. R., Eipper, B. A., Mains, R. E., & Huganir, R. L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01168-6 · Cited by 466
Metadata
- Authors
- Feng, J., Yan, Z., Ferreira, A., Tomizawa, K., Liauw, J. A., Zhuo, M., Allen, P. B., Ouimet, C. C., & Greengard, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-08
- Volume
- 97
- Issue
- 16
- Pages
- 9287-9292
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1990483753
- Cited by
- 375
- References
- 4
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Feng, J., Yan, Z., Ferreira, A., Tomizawa, K., Liauw, J. A., Zhuo, M., Allen, P. B., Ouimet, C. C., & Greengard, P. (2000). Spinophilin regulates the formation and function of dendritic spines. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.16.9287
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