Cited by 292Ubiquitin and proteasome pathwaysHIV Research and TreatmentT-cell and Retrovirus Studies

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Ubiquitin is part of the retrovirus budding machinery

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Patnaik, Akash, Chau, Vincent, Wills, John W.·2000·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.97.24.13069PMC PMC27179

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Abstract

Retroviruses contain relatively large amounts of ubiquitin, but the significance of this finding has been unknown. Here, we show that drugs that are known to reduce the level of free ubiquitin in the cell dramatically reduced the release of Rous sarcoma virus, an avian retrovirus. This effect was suppressed by overexpressing ubiquitin and also by directly fusing ubiquitin to the C terminus of Gag, the viral protein that directs budding and particle release. The block to budding was found to be at the plasma membrane, and electron microscopy revealed that the reduced level of ubiquitin results in a failure of mature virus particles to separate from each other and from the plasma membrane during budding. These data indicate that ubiquitin is actually part of the budding machinery.

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Self-citation
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Authors: Patnaik, A., Chau, V., & Wills, J. W.
Affiliations: Pennsylvania State University (US)
ORCID: Patnaik, Akash
Chau, Vincent
Wills, John W.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2000-11-21
Volume: 97
Issue: 24
Pages: 13069-13074
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.97.24.13069
PMC: PMC27179
OpenAlex: W2060316418
Cited by: 292
References: 46
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 8 · 2012: 6
FWCI: 11.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA047482, CA-47482, R37CA047482)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords: ubiquitin, Rous sarcoma virus, Gag protein, viral particle release, plasma membrane, viral assembly, avian retroviruses
MeSH terms: Acetylcysteine, Animals, Avian Sarcoma Viruses, Cell Line, Cell Membrane, Cysteine Endopeptidases, Endocytosis, Leupeptins, Multienzyme Complexes, Oligopeptides, Protease Inhibitors, Quail, Recombinant Fusion Proteins, Ubiquitins, Virus Replication, Gene Products, gag, Proteasome Endopeptidase Complex

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Ubiquitin is part of the retrovirus budding machinery

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