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Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity
Open accessAbstract
A covalent conjugate (NR-LU-10/SA) was prepared between streptavidin (SA) and NR-LU-10, a mAb that binds an antigen expressed on the surface of most human carcinomas. NR-LU-10/SA was injected into nude mice bearing human tumor xenografts. Injection of biotinylated galactosyl-human serum albumin reduced the circulating levels of conjugate by 95%. Subsequent administration of 90 Y-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-biotin achieved peak uptake at the tumor within 2 hr while >80% of the radioactivity was eliminated in the urine. A single dose of 600–800 μCi of 90 Y-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-biotin produced cures in 10/10 mice with established (>200 mm 3 ) s.c. human small cell lung or colon cancer xenografts and 8/10 cures in mice with human breast cancer xenografts without significant toxicity.
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Radiolabeled-Antibody Therapy of B-Cell Lymphoma with Autologous Bone Marrow Support
Press, O. W., Eary, J. F., Appelbaum, F. R., Martin, P. J., Badger, C. C., Nelp, W. B., Glenn, S., Butchko, G., Fisher, D., Porter, B., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310213291702 · Cited by 644
Cited by
Immunotherapy: past, present and future
Waldmann, T. A. (2003) · Nature Medicine · doi:10.1038/nm0303-269 · Cited by 628
Radioimmunotherapy of human tumours
Larson, S. M., Carrasquillo, J. A., Cheung, N.-K. V., & Press, O. W. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3925 · Cited by 537
Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins
Ghaderi, D., Taylor, R. E., Padler-Karavani, V., Diaz, S., & Varki, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1651 · Cited by 372
Antibody Pretargeting Advances Cancer Radioimmunodetection and Radioimmunotherapy
Goldenberg, D. M., Sharkey, R. M., Paganelli, G., Barbet, J., & Chatal, J.-F. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.8471 · Cited by 351
Therapeutic Radionuclides: Biophysical and Radiobiologic Principles
Kassis, A. I. (2008) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2008.05.002 · Cited by 306
Metadata
- Authors
- Axworthy, D. B., Reno, J. M., Hylarides, M. D., Mallett, R. W., Theodore, L. J., Gustavson, L. M., Su, F.-M., Hobson, L. J., Beaumier, P. L., & Fritzberg, A. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-02-15
- Volume
- 97
- Issue
- 4
- Pages
- 1802-1807
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004224153
- Cited by
- 230
- References
- 1
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Axworthy, D. B., Reno, J. M., Hylarides, M. D., Mallett, R. W., Theodore, L. J., Gustavson, L. M., Su, F.-M., Hobson, L. J., Beaumier, P. L., & Fritzberg, A. R. (2000). Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.4.1802
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