The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The genetics of ivermectin resistance in Caenorhabditis elegans
Open accessAbstract
The ability of organisms to evolve resistance threatens the effectiveness of every antibiotic drug. We show that in the nematode Caenorhabditis elegans, simultaneous mutation of three genes, avr-14, avr-15 , and glc-1 , encoding glutamate-gated chloride channel (GluCl) α-type subunits confers high-level resistance to the antiparasitic drug ivermectin. In contrast, mutating any two channel genes confers modest or no resistance. We propose a model in which ivermectin sensitivity in C. elegans is mediated by genes affecting parallel genetic pathways defined by the family of GluCl genes. The sensitivity of these pathways is further modulated by unc-7 , unc-9 , and the Dyf (dye filling defective) genes, which alter the structure of the nervous system. Our results suggest that the evolution of drug resistance can be slowed by targeting antibiotic drugs to several members of a multigene family.
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Cites
The pharynx of Caenorhabditis elegans
Albertson, D. G., & Thompson, J. N. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0085 · Cited by 649
Cited by
Drug resistance in veterinary helminths
Wolstenholme, A. J., Fairweather, I., Prichard, R., von Samson-Himmelstjerna, G., & Sangster, N. C. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.07.010 · Cited by 813
Moxidectin and the avermectins: Consanguinity but not identity
Prichard, R., Ménez, C., & Lespine, A. (2012) · International Journal for Parasitology: Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2012.04.001 · Cited by 439
A cellular and regulatory map of the cholinergic nervous system of C. elegans
Pereira, L., Kratsios, P., Serrano-Saiz, E., Sheftel, H., Mayo, A. E., Hall, D. H., White, J. G., LeBoeuf, B., Garcia, L. R., Alon, U., et al. (2015) · eLife · doi:10.7554/elife.12432 · Cited by 365
Genetic variability following selection of Haemonchus contortus with anthelmintics
Prichard, R. (2001) · Trends in Parasitology · doi:10.1016/s1471-4922(01)01983-3 · Cited by 289
Hart, A. (2006) · WormBook · doi:10.1895/wormbook.1.87.1 · Cited by 156
Metadata
- Authors
- Dent, J. A., Smith, M. M., Vassilatis, D. K., & Avery, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-03-14
- Volume
- 97
- Issue
- 6
- Pages
- 2674-2679
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971446667
- Cited by
- 455
- References
- 1
- FWCI
- 32.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Dent, J. A., Smith, M. M., Vassilatis, D. K., & Avery, L. (2000). The genetics of ivermectin resistance in Caenorhabditis elegans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.6.2674
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
