The DOI matches its Crossref record.
High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Open accessAbstract
We describe here a system for the rapid identification, assay development, and characterization of gene-based single nucleotide polymorphisms (SNPs). This system couples informatics tools that mine candidate SNPs from public expressed sequence tag resources and automatically designs assay reagents with detection by a chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry platform. As a proof of concept of this system, a genomewide collection of reagents for 9,115 gene-based SNP genetic markers was rapidly developed and validated. These data provide preliminary insights into patterns of polymorphism in a genomewide collection of gene-based polymorphisms.
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Citations
Cited by
Clemson, C. M., Hutchinson, J. N., Sara, S. A., Ensminger, A. W., Fox, A. H., Chess, A., & Lawrence, J. B. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.026 · Cited by 1,445
Accessing genetic variation: genotyping single nucleotide polymorphisms
Syvänen, A.-C. (2001) · Nature Reviews Genetics · doi:10.1038/35103535 · Cited by 1,083
The Desorption Process in MALDI
Dreisewerd, K. (2003) · Chemical Reviews · doi:10.1021/cr010375i · Cited by 709
Methods for Genotyping Single Nucleotide Polymorphisms
Kwok, P.-Y. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.235 · Cited by 580
Downing, T., Imamura, H., Decuypere, S., Clark, T. G., Coombs, G. H., Cotton, J. A., Hilley, J. D., de Doncker, S., Maes, I., Mottram, J. C., et al. (2011) · Genome Research · doi:10.1101/gr.123430.111 · Cited by 423
Metadata
- Authors
- Buetow, K. H., Edmonson, M., MacDonald, R., Clifford, R., Yip, P., Kelley, J., Little, D. P., Strausberg, R., Koester, H., Cantor, C. R., & Braun, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-02
- Volume
- 98
- Issue
- 2
- Pages
- 581-584
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093166014
- Cited by
- 459
- References
- 0
- FWCI
- 23.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Buetow, K. H., Edmonson, M., MacDonald, R., Clifford, R., Yip, P., Kelley, J., Little, D. P., Strausberg, R., Koester, H., Cantor, C. R., & Braun, A. (2001). High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.2.581
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