The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco
Open accessAbstract
Hypersensitive response (HR), a form of programmed cell death, is frequently associated with plant disease resistance. It has been proposed that mitogen-activated protein kinase (MAPK) cascades regulate HR cell death based on pharmacological studies by using kinase inhibitors. However, direct evidence is lacking. Here, we demonstrate that NtMEK2, a MAPK kinase, is upstream of salicylic acid-induced protein kinase (SIPK) and wounding-induced protein kinase (WIPK), two tobacco MAPKs that are activated by various pathogens or pathogen-derived elicitors. Expression of a constitutively active mutant of NtMEK2 induces HR-like cell death in tobacco, which is preceded by the activation of endogenous SIPK and WIPK. In addition, NtMEK2-SIPK/WIPK cascade appears to control the expression of 3-hydroxy-3-methylglutaryl CoA reductase ( HMGR ) and l -phenylalanine ammonia lyase ( PAL ), two defense genes encoding key enzymes in the phytoalexin and salicylic acid biosynthesis pathways. These results demonstrate that a plant MAPK cascade controls multiple defense responses against pathogen invasion.
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Cites
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728
Cited by
MAP kinase signalling cascade in Arabidopsis innate immunity
Asai, T., Tena, G., Plotnikova, J., Willmann, M. R., Chiu, W.-L., Gomez-Gomez, L., Boller, T., Ausubel, F. M., & Sheen, J. (2002) · Nature · doi:10.1038/415977a · Cited by 2,726
Cell Signaling during Cold, Drought, and Salt Stress
Xiong, L., Schumaker, K. S., & Zhu, J.-K. (2002) · The Plant Cell · doi:10.1105/tpc.000596 · Cited by 2,372
The MKK2 Pathway Mediates Cold and Salt Stress Signaling in Arabidopsis
Teige, M., Scheikl, E., Eulgem, T., Dóczi, R., Ichimura, K., Shinozaki, K., Dangl, J. L., & Hirt, H. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.023 · Cited by 1,002
Xiong, L., & Yang, Y. (2003) · The Plant Cell · doi:10.1105/tpc.008714 · Cited by 837
MAPK cascades in plant defense signaling
Zhang, S., & Klessig, D. F. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(01)02103-3 · Cited by 773
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Metadata
- Authors
- Yang, K.-Y., Liu, Y., & Zhang, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-16
- Volume
- 98
- Issue
- 2
- Pages
- 741-746
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043161126
- Cited by
- 478
- References
- 1
- FWCI
- 43.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, K.-Y., Liu, Y., & Zhang, S. (2001). Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.2.741
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